Výsledky vyhledávání - "R. F. Schinazi"

Marine Natural Products as Lead Anti-HIV Agents

Autor: D J, Gochfeld, K A, El Sayed, M, Yousaf, J F, Hu, P, Bartyzel, D C, Dunbar, S P, Wilkins, J K, Zjawiony, R F, Schinazi, S, Schlueter Wirtz, P M, Tharnish, M T, Hamann

Publikováno v: Mini-Reviews in Medicinal Chemistry. 3:401-424

Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25186d89b8754b350ab5615bffd23cb9
https://doi.org/10.2174/1389557033487962

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Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys

Autor: Huizhong Chen, F. D. Boudinot, R. F. Schinazi, Chung K. Chu, H M Mcclure

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:2332-2336

(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized dioxolanylpurine nucleoside derivatives being developed as potential prodrugs for the antiviral nucleoside analog (-)-beta-D-diox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da687217dde76246e0dcf930a3f02140
https://doi.org/10.1128/aac.40.10.2332

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Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks

Autor: R. F. Schinazi, B. H. Baldwin, Chung K. Chu, B. C. Tennant, Prabhu Rajagopalan, F. D. Boudinot

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:642-645

The woodchuck (Marmota monax) has proven to be a suitable animal model for studying hepatitis B virus (HBV) infection owing to similarities in the course of infection between woodchuck hepatitis virus (WHV) in woodchucks and HBV in humans. (-)-beta-L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf60bf1026d775b36bb45c8377f8c0b
https://doi.org/10.1128/aac.40.3.642

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Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates

Autor: Edward Arnold, Holly Bazmi, R. F. Schinazi, J. Weir, D. L. Mayers, John W. Mellors, Y. Hsiou, B. M. Roy

Publikováno v: Antimicrobial Agents and Chemotherapy. 39:1087-1092

Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4315cf9786be946ecfc061d3c706ca
https://doi.org/10.1128/aac.39.5.1087

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Synthesis of enantiomerically pure cyclopropyl carbocyclic nucleosides

Autor: Yufen Zhao, Jinfa Du, R. F. Schinazi, Chung K. Chu, Doowon Lee, M. Gary Newton, Migyoung Lee, Te-Fang Yang, Byoung K. Chun

Publikováno v: Tetrahedron Letters. 35:5405-5408

The enantiomeric synthesis of cyclopropyl carbocyclic nucleosides has been achieved and the key intermediate was characterized by X-ray crystallography.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15416915ea20720f981141955990c4e5
https://doi.org/10.1016/s0040-4039(00)73511-8

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Laboratory safety considerations

Autor: P M, Feorino, J D, Williamson, R F, Schinazi

Publikováno v: Methods in molecular medicine. 24

In the laboratory it is important that potentially pathogenic agents be controlled to protect the laboratory worker from infection and the experiment from contamination. The operation of a safe laboratory depends on many factors: the training and jud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e046fab18a6f550817a2a88d7f37b37
https://pubmed.ncbi.nlm.nih.gov/21331896

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