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Akademický článek

Influence of plasma processing on recovery and analysis of circulating nucleic acids.

Autor: Karen Page, David S Guttery, Nathalie Zahra, Lindsay Primrose, Shona R Elshaw, J Howard Pringle, Kevin Blighe, Stephanie D Marchese, Allison Hills, Laura Woodley, Justin Stebbing, R Charles Coombes, Jacqueline A Shaw

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77963 (2013)

Circulating nucleic acids (CNAs) are under investigation as a liquid biopsy in cancer. However there is wide variation in blood processing and methods for isolation of circulating free DNA (cfDNA) and microRNAs (miRNAs). Here we compare the extractio

Externí odkaz: https://doaj.org/article/944c8282c5394da3b6e8e053a06c57e6

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Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration

Autor: Alan J. Knox, Neil Henderson, L. J. Markwick, Shona R. Elshaw, Anette M. Freyer, Simon R. Johnson

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L1030-L1038

Increased proinflammatory mediators and ECM deposition are key features of the airways in asthma. Matrix metalloproteinases (MMPs) are produced by airway smooth muscle (ASM) cells and have multiple roles in inflammation and tissue remodeling. We hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85270b807a227f83a820e9635369dc5
https://doi.org/10.1152/ajplung.00317.2006

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Matrix metalloproteinase expression and activity in human airway smooth muscle cells

Autor: Simon R. Johnson, Shona R. Elshaw, Alan J. Knox, Susan A. Watson, Neil Henderson, David J. Buttle

Publikováno v: British Journal of Pharmacology. 142:1318-1324

Airway remodelling is a feature of chronic asthma comprising smooth muscle hypertrophy and deposition of extracellular matrix (ECM) proteins. Matrix metalloproteinases (MMPs) breakdown ECM, are involved in tissue remodelling and have been implicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72f0532667f42363a39c2e81b0ca4d14
https://doi.org/10.1038/sj.bjp.0705883

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Expression of integrins, degradative enzymes and their inhibitors in uveal melanoma: differences between in vitro and in vivo expression

Autor: M A Parsons, G. E. L. Mathewman, Karen Sisley, J. K. L. Baker, Shona R. Elshaw, AK Murray, Carmel E. Nichols, I G Rennie

Publikováno v: Melanoma Research. 11:265-273

Posterior uveal melanoma is the most common intraocular malignancy in adults. Metastasis occurs in approximately 40% of all cases and spread is primarily to the liver. Once secondary hepatic disease has developed the prognosis is poor. Metastasis inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaadf3371c80b79d34e439bbccd5c21
https://doi.org/10.1097/00008390-200106000-00008

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A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of α1β1, α4β1 and α6β1 integrins

Autor: Shiela M MacNeil, Neil Cross, M. Wagner, Anna K Murray, Carmel E. Nichols, Karen Sisley, Shona R. Elshaw, I G Rennie

Publikováno v: British Journal of Ophthalmology. 85:732-738

BACKGROUND/AIMS Posterior uveal melanoma is the most common intraocular tumour in adults, responsible for the death of approximately 35% of patients. Hepatic metastases are most frequent, and once diagnosed survival is usually less than 1 year. The �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f68124ca03b6a90c80398d63573180aa
https://doi.org/10.1136/bjo.85.6.732

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Invasive and noninvasive uveal melanomas have different adhesive properties

Autor: Julia K. L. Woodward, Shona R. Elshaw, J. L. Burn, Karen Sisley, Ian G. Rennie

Publikováno v: Eye (London, England). 19(3)

To establish if invasive and noninvasive uveal melanomas have differences in expression of adhesion molecules, and whether their adhesive interactions with the extracellular matrix (ECM) and endothelium vary.Cells from an invasive and noninvasive uve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb0f274b03dc85bd56c408fc9a30051
https://pubmed.ncbi.nlm.nih.gov/15258612

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A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of alpha1beta1, alpha4beta1 and alpha6beta1 integrins

Autor: S R, Elshaw, K, Sisley, N, Cross, A K, Murray, S M, MacNeil, M, Wagner, C E, Nichols, I G, Rennie

Publikováno v: The British journal of ophthalmology. 85(6)

Posterior uveal melanoma is the most common intraocular tumour in adults, responsible for the death of approximately 35% of patients. Hepatic metastases are most frequent, and once diagnosed survival is usually less than 1 year. The beta1 family of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac5ad40f3ae170fa862aa753fa900936
https://pubmed.ncbi.nlm.nih.gov/11371496

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Akademický článek

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Akademický článek

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