Zobrazeno 1 - 10
of 82
pro vyhledávání: '"R. Edelmann"'
Publikováno v:
ACS Omega, Vol 8, Iss 2, Pp 2367-2376 (2023)
Externí odkaz:
https://doaj.org/article/65b2b037476442b1a28ba600e1517857
Autor:
Martin R. Edelmann, Christophe Husser, Martina B. Duschmalé, Guy Fischer, Claudia Senn, Erich Koller, Andreas Brink
Publikováno v:
AAPS Open, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract A novel approach to tritium-labeled antisense oligonucleotides (ASO) was established by conjugating N-succinimidyl propionate, as well as maleimide-derivatives, to the 3′-end of ASOs targeting metastasis-associated lung adenocarcinoma tran
Externí odkaz:
https://doaj.org/article/6e1253d853d5484ab910488c12140b07
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1445 (2022)
Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels–Alder (IEDDA) reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) represents an attractive strategy for molecular imaging via antibodies. The advantages of using
Externí odkaz:
https://doaj.org/article/172d1d7a84e54fd7875847c4caebf505
Autor:
Martin R Edelmann, Simon Hauri
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257342 (2021)
Labelling of therapeutic antibodies with radionuclides or fluorophores is routinely used to study their pharmacokinetic properties. A critical assumption in utilizing labelled therapeutic antibodies is that the label has no unfavourable effects on an
Externí odkaz:
https://doaj.org/article/315633afb252420586c82ff217f61f6b
Publikováno v:
Frontiers in Plant Science, Vol 10 (2020)
Understanding plant adaptation mechanisms to prolonged water immersion provides options for genetic modification of existing crops to create cultivars more tolerant of periodic flooding. An important advancement in understanding flooding adaptation w
Externí odkaz:
https://doaj.org/article/f6ce22a11b5742cdbe1561a78ff6d955
Autor:
Martin R. Edelmann
Publikováno v:
RSC Advances. 12:32383-32400
Radiolabelling small molecules with beta-emitters has been intensively explored in the last decades and novel concepts for the introduction of radionuclides continue to be reported regularly. New catalysts that induce carbon/hydrogen activation are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb7a150423f354d7c35cd62108cbbe9
https://doi.org/10.1039/d2ra06236d
https://doi.org/10.1039/d2ra06236d
Autor:
Thorsten Muser, Martin R. Edelmann
Publikováno v:
Edelmann, M R & Muser, T 2021, ' Tritium O-Methylation of N-Alkoxy Maleimide Derivatives as Labeling Reagents for Biomolecules ', Bioconjugate Chemistry, vol. 32, no. 5, pp. 1027-1033 . https://doi.org/10.1021/acs.bioconjchem.1c00202
An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. N-Substituted maleimides containing the hydroxy functionality are O-methylated in a three-step synthesis route, including (1) Diels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a0e2b2ad74827fc2fac10b8e5a1975
https://doi.org/10.1021/acs.bioconjchem.1c00202
https://doi.org/10.1021/acs.bioconjchem.1c00202
Autor:
Martina Brigitte Duschmalé, Erich Koller, Andreas Brink, Claudia Senn, Guy Fischer, Christophe Husser, Martin R. Edelmann
Publikováno v:
AAPS Open, Vol 7, Iss 1, Pp 1-17 (2021)
A novel approach to tritium-labeled antisense oligonucleotides (ASO) was established by conjugating N-succinimidyl propionate, as well as maleimide-derivatives, to the 3′-end of ASOs targeting metastasis-associated lung adenocarcinoma transcript 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5357de7799843d1bab38cee0e3c41984
https://doi.org/10.1186/s41120-021-00040-3
https://doi.org/10.1186/s41120-021-00040-3
Autor:
Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, Michael Honer, Sylwia Huber, Matthias B. Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N. Hug, Manuel Hilbert, Annemarieke G.J. Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D. Krämer, Roger Schibli, Linjing Mu, Luca C. Gobbi
Publikováno v:
European Journal of Medicinal Chemistry, 243:114750. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
European Journal of Medicinal Chemistry, 243
European Journal of Medicinal Chemistry, 243
Monoacylglycerol lipase (MAGL) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. We recently discovered a morpholin-3-one derivative as a novel scaffold fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c55a40e57837b88082305c6a4d833
https://doi.org/10.1016/j.ejmech.2022.114750
https://doi.org/10.1016/j.ejmech.2022.114750
Autor:
Franz Schuler, Filipe Lopes, Simone Schadt, Adrian Roth, Roland F Staack, Wolfgang F. Richter, Roberto Villaseñor, Hubert Kettenberger, Christoph Funk, Martin R. Edelmann, Simon Hauri
Publikováno v:
Drug Metabolism and Disposition. 47:1443-1456
For therapeutic proteins, the currently established standard development path generally does not foresee biotransformation studies by default because it is well known that the clearance of therapeutic proteins proceeds via degradation to small peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7603d176988ce6d7884f289330512a40
https://doi.org/10.1124/dmd.119.088997
https://doi.org/10.1124/dmd.119.088997