Zobrazeno 1 - 9 of 9 pro vyhledávání: '"R. E. Schreck"'
2
Authentic 17kDa tumour necrosis factor α is synthesized and released by canine mast cells and up-regulated by stem cell factor
Autor: D W Pennington, R. E. Schreck, T M Levine, Paul S. Thomas, Stephen C. Lazarus
Publikováno v: Clinical & Experimental Allergy. 26:710-718
Summary Background Previous studies have suggested varying molecular weights for mast cell derived tumour necrosis factor alpha (TNFa) and little data exist upon the factors which may regulate the control of this cytokine in these cells. Objective To
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0199ac2af593319b33abb2722eae2cb
https://doi.org/10.1111/j.1365-2222.1996.tb00598.x
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3
Prostaglandin D2 production and identification of prostaglandin H synthase within canine mast cell granule
Autor: A. N. Wilson, Paul S. Thomas, R. E. Schreck, Stephen C. Lazarus
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 263:L168-L176
We have identified the presence of functional prostaglandin H synthase (PGH synthase, E.C. 1.14.99.1, or cyclooxygenase) within canine mast cell granules by demonstrating the generation of prostaglandin (PG) D2 from isolated and purified granules inc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae42c9431144f7fb5d7a148d7011dd4e
https://doi.org/10.1152/ajplung.1992.263.2.l168
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4
Tobacco smoke releases performed mediators from canine mast cells and modulates prostaglandin production
Autor: Stephen C. Lazarus, Paul S. Thomas, R. E. Schreck
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 263:L67-L72
The role of an extract of tobacco smoke in activating mast cells was studied. With the use of isolated, canine mast cells as a model, we found that cigarette smoke solution (CSS) induced the release of the performed mediators histamine and tryptase f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26387e73bc3e6925742249c58b94174f
https://doi.org/10.1152/ajplung.1992.263.1.l67
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5
High levels of HER-2 expression alter the ability of epidermal growth factor receptor (EGFR) family tyrosine kinase inhibitors to inhibit EGFR phosphorylation in vivo
Autor: J G, Christensen, R E, Schreck, E, Chan, X, Wang, C, Yang, L, Liu, J, Cui, L, Sun, J, Wei, J M, Cherrington, D B, Mendel
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(12)
The epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases have been implicated in the development, progression, and severity of several human cancers and are attractive targets for therapeutic intervention. SU11925 was developed as a sma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ef1f64019542a5724c467d5c23ba39c
https://pubmed.ncbi.nlm.nih.gov/11751524
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6
The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function
Autor: D B, Mendel, R E, Schreck, D C, West, G, Li, L M, Strawn, S S, Tanciongco, S, Vasile, L K, Shawver, J M, Cherrington
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(12)
SU5416, a selective inhibitor of the tyrosine kinase activity of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR, is currently in Phase III clinical trials for the treatment of advanced malignancies. In cellular assays, SU5416 inhibi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f858777337e62ff407dc874da23dd5be
https://pubmed.ncbi.nlm.nih.gov/11156244
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7
Authentic 17 kDa tumour necrosis factor alpha is synthesized and released by canine mast cells and up-regulated by stem cell factor
Autor: P S, Thomas, D W, Pennington, R E, Schreck, T M, Levine, S C, Lazarus
Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 26(6)
Previous studies have suggested varying molecular weights for mast cell derived tumour necrosis factor alpha (TNF alpha ) and little data exist upon the factors which may regulate the control of this cytokine in these cells.To determine the molecular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::304489b065d441062a53a5afa9103748
https://pubmed.ncbi.nlm.nih.gov/8809429
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8
Heparin inhibits histamine release from canine mast cells
Autor: N. Inase, Stephen C. Lazarus, R. E. Schreck
Publikováno v: The American journal of physiology. 264(4 Pt 1)
To determine the role of heparin in mast cell exocytosis, we studied the effect of heparin on histamine release induced by compound 48/80 or calcium ionophore A23187 in canine mastocytoma cells (BR). Heparin caused concentration-dependent inhibition
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f523c38f8ad3e243096a3969f01aaa
https://pubmed.ncbi.nlm.nih.gov/7682786
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9
Heterogeneity of intact granules purified from canine mastocytoma cell lines
Autor: R. E. Schreck, Stephen C. Lazarus, S. J. Ruoss, Paul S. Thomas
Publikováno v: The American journal of physiology. 260(2 Pt 1)
We investigated the observation that some mast cells exhibit asynchronous release of granule-associated neutral proteases. Intact mast cell granules were isolated, purified, and studied with respect to their histamine, neutral protease, and proteogly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c439033dd5692ec9dc1976662a6992af
https://pubmed.ncbi.nlm.nih.gov/1899974
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