Výsledky vyhledávání - "R. E. Buckingham"

Treatment with the Thiazolidinedione (BRL 49653) Decreases Insulin Resistance in Obese Zucker Hindlimb

Autor: Tpd Eldershaw, Stephen Rattigan, R. E. Buckingham, M. A. Cawthorne, Michael G. Clark, Eric Q. Colquhoun

Publikováno v: Hormone and Metabolic Research. 27:169-172

Hindlimbs of mature age obese fa/fa Zucker rats were perfused and found to be markedly insulin-resistant when compared to the hindlimbs of age-matched lean Fa/? animals. Hindlimb analysis also showed a greater content of fat and a lower content of mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b61c2dda2b5ebffbc038ae8e57f90e7
https://doi.org/10.1055/s-2007-979932

Zobrazit plný text záznamu

Thiazolidinedione insulin sensitizers and the heart: a tale of two organs?

Autor: R. E. Buckingham, A. Hanna

Publikováno v: Diabetes, obesitymetabolism. 10(4)

Thiazolidinediones (TZDs) are relatively new agents for the treatment of type 2 diabetes. They act as agonists at the PPAR-gamma nuclear receptor and their therapeutic effects include decreased insulin resistance and hyperglycaemia, an improved plasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e50ced833b5e43d2ba86d6a1d7a8893
https://pubmed.ncbi.nlm.nih.gov/18333890

Zobrazit plný text záznamu

Energy restriction enhances therapeutic efficacy of the PPARgamma agonist, rosiglitazone, through regulation of visceral fat gene expression

Autor: C. P. Briscoe, Gary B.T. Moore, R. E. Buckingham, John P.H. Wilding, John C. Clapham, Lucy Pickavance

Publikováno v: Diabetes, obesitymetabolism. 10(3)

Aim: Consumption of a palatable diet can induce hyperphagia, leading to weight gain (dietary obesity) and insulin resistance in rats. Thiazolidinediones (TZDs) can also induce hyperphagia in rats but conversely have an insulin-sensitizing effect. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0460777844eb641648c1639d05976b
https://pubmed.ncbi.nlm.nih.gov/18269641

Zobrazit plný text záznamu

Rapid reversal of hepatic steatosis, and reduction of muscle triglyceride, by rosiglitazone: MRI/S studies in Zucker fatty rats

Autor: P D, Hockings, K K, Changani, N, Saeed, D G, Reid, J, Birmingham, P, O'Brien, J, Osborne, C N, Toseland, R E, Buckingham

Publikováno v: Diabetes, obesitymetabolism. 5(4)

This study aimed to chart the time course and durability of the effects of rosiglitazone, a potent thiazolidinedione-based peroxisome proliferator-activated receptor gamma agonist, on hepatic steatosis and intramyocellular lipid in an animal model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5eefa7d854d272584db9d9dcc5581ddd
https://pubmed.ncbi.nlm.nih.gov/12795656

Zobrazit plný text záznamu

Effects of chronic murine and human leptin infusion on plasma leptin and corticosterone levels and energy balance in lean Zucker rats

Autor: K A, Al-Barazanji, R E, Buckingham, J R, Arch, C, Briscoe, O, Jenkins, M, Tadayyon

Publikováno v: Diabetes, obesitymetabolism. 3(6)

To clarify whether centrally delivered leptin can access the circulation and to determine to what extent the effects of i.c.v. h-leptin and m-leptin on body weight and plasma corticosterone are due to reduced food intake.Male lean Zucker rats were in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7839d342e1b2ed30e42f79a7b3b04be
https://pubmed.ncbi.nlm.nih.gov/11903416

Zobrazit plný text záznamu

Insulin-sensitizing action of rosiglitazone is enhanced by preventing hyperphagia

Autor: L C, Pickavance, R E, Buckingham, J P, Wilding

Publikováno v: Diabetes, obesitymetabolism. 3(3)

We investigated whether pair-feeding to prevent hyperphagia would potentiate the insulin-sensitizing effect of rosiglitazone in chow-fed and insulin-resistant dietary obese rats, and studied the role of leptin and hypothalamic neuropeptide Y as media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d476011f77c025c5eb8e7eb722fd0cc1
https://pubmed.ncbi.nlm.nih.gov/11412281

Zobrazit plný text záznamu

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

Autor: D T, Finegood, M D, McArthur, D, Kojwang, M J, Thomas, B G, Topp, T, Leonard, R E, Buckingham

Publikováno v: Diabetes. 50(5)

The evolution of diabetes in the male leptin receptor-deficient (fa/fa) Zucker diabetic fatty (ZDF) rat is associated with disruption of normal islet architecture, beta-cell degranulation, and increased beta-cell death. It is unknown whether these ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09e030f9c3cfd5696f8f712c1bd94755
https://pubmed.ncbi.nlm.nih.gov/11334404

Zobrazit plný text záznamu

Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution

Autor: L C, Pickavance, M, Tadayyon, P S, Widdowson, R E, Buckingham, J P, Wilding

Publikováno v: British journal of pharmacology. 128(7)

1. The blood glucose-lowering efficacy of rosiglitazone (RSG) and the mechanisms of associated weight gain were determined in dietary obese rats (DIOs). DIO and chow-fed rats received RSG 0.3-30 mg kg-1 daily for 21 days. 2. In DIOs, plasma glucose a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cc68d01190d3683a070ead1b5077695
https://pubmed.ncbi.nlm.nih.gov/10602338

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání