Zobrazeno 1 - 10
of 136
pro vyhledávání: '"R. Dubbelman"'
Publikováno v:
Annals of Oncology. 21:530-534
Background Postoperative chemoradiotherapy with concurrent 5-fluorouracil improves gastric cancer outcome. We previously demonstrated that chemoradiotherapy with a more intensified––and therefore potentially more effective––schedule with dail
Autor:
Jolanda M. Smit, A. C. E. Moor, T. M. A. R. Dubbelman, Jan Wilschut, A. E. Wagenaars-Van Gompel, J. Van Der Meulen, R. C. A. Hermanns, Anneke Brand, John VanSteveninck
Publikováno v:
Photochemistry and Photobiology, 69(3), 353-359. Wiley-Blackwell
Vesicular stomatitis virus (VSV) was used as a model virus to study the processes involved in photoinactivation by aluminum phthalocyanine tetrasulfonate (AIPcS(4),) or silicon phthalocyanine HOSiPcOSi(CH3)(2)(CH2)(3)N(CH3)(2) (Pc4) and red light. Pr
Publikováno v:
British Journal of Cancer
We hypothesised that gastric cancer outcome could be improved with more effective and intensified postoperative chemoradiotherapy. This phase I/II study was performed to determine the maximal tolerated dose (MTD) and toxicity profile of postoperative
Autor:
T. Rianne Stoter, M. Vincent M. Lafleur, Frank J. P. Hoebers, Ben J. Slotman, Michiel W. M. van den Brekel, R. Dubbelman, Marcel Verheij, Gitta K. Kuipers, Shuraila F. Zerp
Publikováno v:
Zerp, S F, Stoter, R, Hoebers, F J P, van den Brekel, M W M, Dubbelman, R, Kuipers, G K, Lafleur, M V M, Slotman, B J & Verheij, M 2015, ' Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer ', Radiation Oncology, vol. 10, 158 . https://doi.org/10.1186/s13014-015-0474-9
Radiation Oncology, 10:158. BioMed Central Ltd
Radiation Oncology, 10:158. BioMed Central
Radiation Oncology (London, England)
Radiation Oncology, 10:158. BioMed Central Ltd
Radiation Oncology, 10:158. BioMed Central
Radiation Oncology (London, England)
BackgroundPro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apoptotic Bcl-2 family members. Inc
Autor:
R. Dubbelman, Stefan R. Vink, Jan H.M. Schellens, Gemi Moppi, Harry Bartelink, Herbert Sindermann, Marcel Verheij, Michel J.X. Hillebrand, Jürgen Engel, Jos H. Beijnen
Publikováno v:
Radiotherapy and Oncology. 80:207-213
Purpose Perifosine is an orally applicable, membrane-targeted alkylphosphocholine analogue with antitumour activity and radiosensitising properties in preclinical models. The purpose of this phase I study was to determine the feasibility and tolerabi
Autor:
Wouter H. Moolenaar, Sjoerd Rodenhuis, R. Dubbelman, Jos H. Beijnen, Jan P. Baars, A. M. Westermann
Publikováno v:
Cancer chemotherapy and pharmacology, 46(1), 57-62. Springer Verlag
Purpose: Bioactive lipids have been causally linked to intraabdominal malignancies such as ovarian cancer. In advanced tumors confined to the peritoneal cavity, inhibition of lipid growth factors present in ascites might induce tumor remissions. The
Autor:
R. Dubbelman, Jos H. Beijnen, M. T. Huizing, Laurence J. C. van Warmerdam, Jan H.M. Schellens, I.A.M. Mandjes, Vinodh R. Nannan Panday, Wim W. ten Bokkel Huinink
Publikováno v:
Pharmacological Research. 38:231-236
Paclitaxel (Taxol(R)) is an active agent in platinum-refractory ovarian cancer. Since the available pharmacokinetic data of 135 mg m-2 paclitaxel administered by 3-h infusion are scarce and fragmented, we now describe a comprehensive pharmacologic st
Publikováno v:
The Netherlands Journal of Medicine. 46:62-72
Objective: (1) To assess plasma renin activity (PRA) and plasma aldosterone concentration (PAC) in patients with inferior vena cava syndrome (IVCS). (2) To study in an open fashion the efficacy of loop diuretic treatment, single, or in combination wi
Publikováno v:
American Journal of Clinical Nutrition, 58(1), 106-109. Oxford University Press
Plasma vitamin D metabolites and parathyroid hormone concentrations of two groups of white women, aged 26-46 and 63-83 y, in Curaçao were studied to evaluate the effect of yearlong abundant sunlight on frequency of vertebral compression fractures in
Publikováno v:
Cancer Chemotherapy and Pharmacology. 29:480-484
The pharmacokinetics of intraperitoneally (i.p.) injected mitoxantrone was determined in plasma and peritoneal dialysate taken from five patients presenting with cancer confined to the peritoneal cavity over a sampling period of 1 week. The drug was