Zobrazeno 1 - 10
of 51
pro vyhledávání: '"R. Desnoyers"'
Autor:
Susan K. Lyman, Bjorn L. Millard, Mark Stroh, Michelle Green, Luc R. Desnoyers, Alison L. Hannah, Hong Lu, W. Michael Kavanaugh, Will Garner, Jennifer Richardson, John M. Burke, Joshua F. Apgar
Publikováno v:
Clinical Pharmacology & Therapeutics. 109:383-393
CX-072 is an anti-PD-L1 (programmed death ligand 1) Probody therapeutic (Pb-Tx) designed to be preferentially activated by proteases in the tumor microenvironment and not in healthy tissue. Here, we report the model-informed drug development of CX-07
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f46a6440d1f858738214053dcf6e8cf
https://doi.org/10.1002/cpt.1985
https://doi.org/10.1002/cpt.1985
Autor:
J.M. Makar, R. Desnoyers
Publikováno v:
Underground Infrastructure Research
The remote field effect is an electromagnetic method for inspecting pipes and tubing. It has recently been commercialised as a technique for inspecting gray cast iron and ductile iron water mains. How-ever,commercial tools provide information on pits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1740e245baf24929211cad34c209f6
https://doi.org/10.1201/9781003077480-14
https://doi.org/10.1201/9781003077480-14
Failures in cast iron water mains are more complex and diverse than is widely understood in the industry. This paper discusses the modes and causes of pipe failures that have been encountered during a three year investigation by the National Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74c904a27bed4f071848361223cb5cb4
https://doi.org/10.1201/9781003077480-47
https://doi.org/10.1201/9781003077480-47
Autor:
Dorothy M French, Benjamin C Lin, Manping Wang, Camellia Adams, Theresa Shek, Kathy Hötzel, Brad Bolon, Ronald Ferrando, Craig Blackmore, Kurt Schroeder, Luis A Rodriguez, Maria Hristopoulos, Rayna Venook, Avi Ashkenazi, Luc R Desnoyers
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36713 (2012)
The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes. It is also well documented that dysregulation of FGF-FGFR signaling may have important role
Externí odkaz:
https://doaj.org/article/ef355a6145de4eae90b1a7091709e19e
Autor:
Giovanna R. Fois, Nicolle R. Desnoyers, John A. Olschowka, Ruiliang Wang, Allen G. Meek, Adam Rusek, Dardo Tomasi, I. Dioszegi, Hedok Lee, F. Avraham Dilmanian, Bari Dane, Jane Y. Park, Patricia K. Coyle, Sean D. Hurley, M. Kerry O'Banion
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 84:514-519
Purpose To evaluate the efficacy of "interleaved carbon minibeams" for ablating a 6.5-mm target in a rabbit brain with little damage to the surrounding brain. The method is based on the well-established tissue-sparing effect of arrays of thin planes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57578eaa2031411810d55dfeaeb915e4
https://doi.org/10.1016/j.ijrobp.2011.12.025
https://doi.org/10.1016/j.ijrobp.2011.12.025
Autor:
A. Charkravarti, M. Wang, I. Robins, A. Guha, W. Curren, D. Brachman, C. Schultz, A. Choucair, M. Dolled-Filhart, J. Christiansen, M. Gustavson, A. Molinaro, P. Mischel, T. Lautenschlaeger, A. Dicker, M. Mehta, C. A. Phillips, S. Dhulibala, D. Hallahan, J. Jaboin, F. S. Cardinale, P. Dickey, I. Goodrich, J. Gorelick, R. Sinha, V. M. Dest, C. Chen, C. Olsen, W. Franklin, B. Kleinschmidt-DeMasters, B. D. Kavanagh, K. Lillehei, A. Waziri, D. Damek, L. E. Gaspar, M. C. Stauder, N. N. Laack, M. J. Link, B. E. Pollock, P. J. Schomberg, J. F. Fraser, S. C. Pannullo, J. Moliterno, W. Cobb, P. E. Stieg, S. Vinchon-Petit, D. Jarnet, S. Michalak, A. Lewis, J.-P. Benoit, P. Menei, G. Desmarais, B. Paquette, R. Bujold, D. Mathieu, D. Fortin, K. C. Cuneo, J. J. Vredenburgh, J. H. Sampson, D. A. Reardon, A. Desjardins, K. L. Peters, J. P. Kirkpatrick, P. N. Patel, R. Vyas, U. Suryanarayan, D. Bhavsar, C. Hayhurst, E. Monsalves, M. Van Prooijen, C. Menard, G. Zadeh, C. Chung, K. Burrell, P. Lindsey, S. H. Burri, A. L. Asher, R. B. Kelly, P. Boltes, R. W. Fraser, F. A. Dilmanian, A. Rusek, N. R. Desnoyers, J. Y. Park, B. Dane, I. Dioszegi, S. D. Hurley, M. K. O'Banion, D. Tomasi, R. Wang, A. G. Meek, L. Sleire, J. Wang, J. Heggdal, P.-H. Pedersen, P. O. Enger, D. A. Clump, R. Srinivas, R. E. Wegner, D. E. Heron, S. A. Burton, A. H. Mintz, S. P. Howard, H. I. Robins, W. A. Tome, A. J. Paravati, P. A. Gardner, C. Snyderman, C. Ozhasoglu, A. Quinn, K. Seelman, J. H. Chang, Y. G. Park, M. J. Mehta, R. K. Vyas, D. C. Bhavsar, J. N. Guarnaschelli, L. Imwalle, J. Ying, C. McPherson, R. Warnick, J. Breneman, S. S. Khwaja, N. M. Wetjen, P. D. Brown, M. Siedow, U. Nestler, J. Perry, A. Huebner, A. Chakravarti, J. Glass, D. Andrews, M. Werner-Wasik, J. Evans, R. Lawrence, N. Martinez, G. Anuradha, M. David, M. Sara, L. Mark, B. Ricardo, J. Jeff, H. Juan, D. Kozono, P. Zinn, K. Ng, E. Melian, V. Prabhu, A. Sethi, K. Barton, D. Anderson, R. C. Rockne, M. Mrugala, J. Rockhill, K. R. Swanson
Publikováno v:
Neuro-Oncology. 12:iv105-iv112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3daf119ed9f17d733d99cff108ac5067
https://doi.org/10.1093/neuonc/noq116.s15
https://doi.org/10.1093/neuonc/noq116.s15
Autor:
Mark Stroh, Karen A. Autio, Matthias Will, Rachel Humphrey, Beiyao Zheng, Valentina Boni, James Strauss, Johanna C. Bendell, Luc R. Desnoyers, Amy Weise, Naiyer A. Rizvi, Bert H. O'Neil, Alexander I. Spira, Nataliya Volodymyrivna Uboha, Lori Carman, Anthony B. El-Khoueiry, Aung Naing, Hendrik-Tobias Arkenau
Publikováno v:
Journal of Clinical Oncology. 36:3071-3071
3071Background: In single-agent trials, antibodies (Abs) targeting programmed cell death ligand 1 (PD-L1) improve survival in many cancers but are associated with immune-related toxicities (most co...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16da7b9e9d120a01959ac5b3dbcdc4f4
https://doi.org/10.1200/jco.2018.36.15_suppl.3071
https://doi.org/10.1200/jco.2018.36.15_suppl.3071
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Autor:
Fei Han, Shouchun Liu, Stephen James Moore, Jennifer Richardson, Jason Gee, Annie Yang, Olga Vasiljeva, Margaret Nguyen, Luc R. Desnoyers, Kenneth R. Wong, Kate Markham, Elizabeth Menendez, Kathy Kamath, Tony W. Liang, Jeanne Grace Flandez, Daniel R. Hostetter, James W. West, Chihunt Wong, Paul H. Bessette, Henry B. Lowman, Michael Krimm, Patrick S. Daugherty, Jason Gary Sagert
Publikováno v:
Science Translational Medicine. 5
Target-mediated toxicity constitutes a major limitation for the development of therapeutic antibodies. To redirect the activity of antibodies recognizing widely distributed targets to the site of disease, we have applied a prodrug strategy to create
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db22ff4ba0636787e1f4574421baf32
https://doi.org/10.1126/scitranslmed.3006682
https://doi.org/10.1126/scitranslmed.3006682
Autor:
F. Avraham Dilmanian, Arthur L. Jenkins, Saffa Ahmad, Catherine R. Messina, Allen G. Meek, LeeAnn Trojanczyk, Stanislaw Sobotka, Nicolle R. Desnoyers, Patricia K. Coyle, Marjorie Morales, John A. Olschowka, Sean D. Hurley, Neda Shahrabi, Giovanna R. Fois, Zhong Zhong, Jane Y. Park, M. Kerry O'Banion
Publikováno v:
Radiation research. 179(1)
Spinal cord injury is a devastating condition with no effective treatment. The physiological processes that impede recovery include potentially detrimental immune responses and the production of reactive astrocytes. Previous work suggested that radia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cfe6884be8ffa6b881dda262ce946a
https://pubmed.ncbi.nlm.nih.gov/23216524
https://pubmed.ncbi.nlm.nih.gov/23216524