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Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Autor: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet, F. Malagnac

Publikováno v: Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-28 (2021)

Abstract Background Selective gene silencing is key to development. It is generally accepted that H3K27me3-enriched heterochromatin maintains transcriptional repression established during early development and regulates cell fate. Conversely, H3K9me3

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Akademický článek

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Additional file 12 of Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Autor: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet, Malagnac, F.

Additional file 12: Figure S12. Longevity tests for ΔPaKmt1 and ΔPaKmt6 strains. Graphs show the maximal growth length on M2 medium at 27 °C in race tubes for wild-type (WT), ΔPaKmt1 and ΔPaKmt6 mutant strains for both mating types. Data corresp

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Additional file 4 of Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Autor: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet, Malagnac, F.

Additional file 4: Figure S4. Combined epigenetic landscapes in wild-type and heterochromatin mutant strains of P. anserina. Panorama of genome-wide peak localization for each genotype, wild-type, ΔPaKmt1, ΔPaKmt6 and ΔPaHP1 strains. Telomeres seq

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Additional file 9 of Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Autor: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet, Malagnac, F.

Additional file 9: Figure S9. Localization of histone marks on specific genomic regions in the ΔPaKmt1 and ΔPaKmt6 mutant strains. Top panel: Plots of normalized ChIP-seq signal. Bottom panel: Heatmaps divided in K-means built clusters representing

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Additional file 7 of Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Autor: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet, Malagnac, F.

Additional file 7: Figure S7. Antibody specificity analysis. Dot blot results using H3K9me3 and H3K27me3 peptides (left) at different concentration (top). Membranes were inoculated with the corresponding antibody (right). Signal intensity comparison

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Additional file 6 of Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Autor: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet, Malagnac, F.

Additional file 6: Figure S6. Snapshots of a set of TEs representing all the annotated TE families in P. anserina’s genome. ChIP-seq signals were normalized as described in “Methods” and visualized using the Integrated Genomics Viewer (IGV) [11

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Additional file 5 of Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Autor: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet, Malagnac, F.

Additional file 5: Figure S5. H3K4me3, H3K27me3 and H3K9me3 modifications of P. anserina TEs in the WT, ΔPaKmt1, ΔPaKmt6 and ΔPaHP1 mutant strains. A. Histone marks on P. anserina TE families. Top panel: Plots of normalized ChIP signal: H3K4me3 (g

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Additional file 8 of Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Autor: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet, Malagnac, F.

Additional file 8: Figure S8. Molecular characterization of knockout mutants by Southern blot hybridization. Schematic representations of the endogenous and disrupted loci are given (Left). Replacement by homologous recombination of the wild-type PaK

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