Zobrazeno 1 - 10
of 107
pro vyhledávání: '"R. David Andrew"'
Autor:
Julia A. Hellas, R. David Andrew
Publikováno v:
Neurocritical Care
An acute reduction in plasma osmolality causes rapid uptake of water by astrocytes but not by neurons, whereas both cell types swell as a consequence of lost blood flow (ischemia). Either hypoosmolality or ischemia can displace the brain downwards, p
Publikováno v:
Journal of Alzheimer's Disease
Background: Neuronal damage resulting from increased oxidative stress is important in the development of late onset/age-related Alzheimer’s disease (LOAD). We have developed an oxidative stress–related mouse model of LOAD based on gene deletion o
Autor:
R. David Andrew, Brian M. Bennett, Hilaree N. Frazier, Adam O. Ghoweri, John C. Gant, Peter J. Gagolewicz, Olivier Thibault
Publikováno v:
Journal of Alzheimer's Disease
Background: Dysregulated signaling in neurons and astrocytes participates in pathophysiological alterations seen in the Alzheimer’s disease brain, including increases in amyloid-β, hyperphosphorylated tau, inflammation, calcium dysregulation, and
Publikováno v:
Neuroscience. 442:202-215
The Na+/K+-ATPase is a transmembrane ion pump that has a critical homeostatic role within every mammalian cell; however, it is vulnerable to the effects of increased oxidative stress. Understanding how expression of this transporter is influenced by
Publikováno v:
J Neurophysiol
Neural function depends on maintaining cellular membrane potentials as the basis for electrical signaling. Yet, in mammals and insects, neuronal and glial membrane potentials can reversibly depolarize to zero, shutting down neural function by the pro
Autor:
R. David Andrew, Jed A. Hartings, Cenk Ayata, K. C. Brennan, Ken D. Dawson-Scully, Eszter Farkas, Oscar Herreras, Sergei. A. Kirov, Michael Müller, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, C. William Shuttleworth, Ghanim Ullah, Jens P. Dreier
Background: When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their jeopardized neurons. One crucial reason is that we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe864e07338390ac93ed1c0a207aabc3
https://doi.org/10.1007/s12028-021-01431-w
https://doi.org/10.1007/s12028-021-01431-w
Autor:
R. David Andrew, Eszter Farkas, Jed A. Hartings, K. C. Brennan, Oscar Herreras, Michael Müller, Sergei. A. Kirov, Cenk Ayata, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, Ken D. Dawson-Scully, Ghanim Ullah, Jens P. Dreier
Publikováno v:
Neurocritical care. 37(Suppl 1)
Background: Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue, expanding the neuronal damage. This period represents
Autor:
Albert Y. Jin, R. David Andrew, Dylan Petrin, Rasha H. Mehder, Brian M. Bennett, Peter J. Gagolewicz
Publikováno v:
J Neurophysiol
Whereas many studies have examined the properties of the compromised neocortex in the first several days following ischemia, there is less information regarding the initial 12 h poststroke. In this study we examined live mouse neocortical slices harv
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96585 (2014)
Global ischemia caused by heart attack, pulmonary failure, near-drowning or traumatic brain injury often damages the higher brain but not the brainstem, leading to a 'persistent vegetative state' where the patient is awake but not aware. Approximatel
Externí odkaz:
https://doaj.org/article/7cd2c9cc33724b7581ae15e1851e4c56
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79589 (2013)
Higher brain regions are more susceptible to global ischemia than the brainstem, but is there a gradual increase in vulnerability in the caudal-rostral direction or is there a discrete boundary? We examined the interface between `higher` thalamus and
Externí odkaz:
https://doaj.org/article/805fb9bc5d7b4077b87fedd0fecb2eb7