Výsledky vyhledávání - "R. D. Whalen"

Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions

Autor: D.J. Tweedie, J.J. Miceli, A. Kamel, D. Cui, C. Prakash, R. D. Whalen

Publikováno v: British Journal of Clinical Pharmacology. 49:35-42

Aims To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6bed5d792f8fecc5ffe263f58379b1b
https://doi.org/10.1046/j.1365-2125.2000.00151.x

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Species differences in the hepatic and intestinal metabolism of cyclosporine

Autor: R. D. Whalen, Prasad Tata, Gilbert J. Burckart, Raman Venkataramanan

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 29(1)

1. Cyclosporin A (cyclosporine, CSA) is an immunosuppressive drug with a narrow therapeutic index. In the present study the metabolism of CSA was investigated in the liver and small intestinal microsomes obtained from rat, hamster, rabbit, dog, baboo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b373318c7ab41f7e9f9faf3c55c9e4
https://pubmed.ncbi.nlm.nih.gov/10078836

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Ziprasidone metabolism and cytochrome P450 isoforms

Autor: J.J. Miceli, C. Prakash, A. Kamel, D.J. Tweedie, D. Cui, R. D. Whalen

Publikováno v: Biological Psychiatry. 42:40S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70a69eb4f0da9c3e8bdc12bfa5f9d1da
https://doi.org/10.1016/s0006-3223(97)87042-4

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