Zobrazeno 1 - 10 of 36 pro vyhledávání: '"R. D. WAIGH"'
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Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice
Autor: M H, Mooney, S, Fogarty, C, Stevenson, A M, Gallagher, P, Palit, S A, Hawley, D G, Hardie, G D, Coxon, R D, Waigh, R J, Tate, A L, Harvey, B L, Furman
Publikováno v: British journal of pharmacology. 153(8)
Galegine and guanidine, originally isolated from Galega officinalis, led to the development of the biguanides. The weight-reducing effects of galegine have not previously been studied and the present investigation was undertaken to determine its mech
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53d0fb52f4ff950a0f7d2cd871d4358c
https://pubmed.ncbi.nlm.nih.gov/18297106
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4
Quaternary ammonium palmitoyl glycol chitosan--a new polysoap for drug delivery
Autor: I F, Uchegbu, L, Sadiq, M, Arastoo, A I, Gray, W, Wang, R D, Waigh, A G, Schätzlein, A G, Schätzleinä
Publikováno v: International journal of pharmaceutics. 224(1-2)
A new polysoap, quaternary ammonium palmitoyl glycol chitosan (GCPQ, M(w)=178,000 g mole(-1)) with drug solubilising potential has been synthesised and characterised. In solution hydrophobic domains of GCPQ polymeric micelles were identified by the h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcf61e14b013978124449e2933913b9
https://pubmed.ncbi.nlm.nih.gov/11472828
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5
The effect of 12-alkoxy modification on the in vitro antileukaemic activity of N-methyl 2,3,8,9-tetramethoxybenzo[c]phenanthridinium salts
Autor: S P, Mackay, L, Comoe, B, Desoize, O, Duval, J C, Jardillier, R D, Waigh
Publikováno v: Anti-cancer drug design. 13(7)
Some members of a series of 12-alkyloxy benzo[c]phenanthridines are potent inhibitors of the growth of P388 tumour cells in vitro, with a strong dependence on the nature of the 12-substituent. Analogues with a quaternary nitrogen in the side chain bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::073138abc16832bc8cc6c479dd6da9af
https://pubmed.ncbi.nlm.nih.gov/9807163
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6
Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy
Autor: S. F. Dossaji, D. M. N. Gakunju, P. G. Waterman, A. I. Gray, R. D. Waigh, William M. Watkins, E. K. Mberu
Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc0cf9f0fc60c4e9c0e9f9890abf1e3
https://europepmc.org/articles/PMC162997/
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8
Antibacterial action of 2-bromo-2-nitropropane-1,3-diol (bronopol)
Autor: J A Shepherd, R D Waigh, Peter Gilbert
Publikováno v: Antimicrobial Agents and Chemotherapy. 32:1693-1698
Patterns of growth inhibition of Escherichia coli in the presence of 2-bromo-2-nitropropane-1,3-diol (bronopol) indicate a period of biocide-induced bacteriostasis followed by growth at an inhibited rate. The length of the bacteriostatic period, but
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2045d40958464ee43ea63afe7c5fe50
https://doi.org/10.1128/aac.32.11.1693
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