Výsledky vyhledávání - "R. D. Tillyer"

Practical Asymmetric Synthesis of a Potent Cathepsin K Inhibitor. Efficient Palladium Removal Following Suzuki Coupling

Autor: Xin Wang, Joel Robichaud, Peppi Prasit, Cheng-yi Chen, Renata Oballa, Edward J. J. Grabowski, R. D. Tillyer, Philippe Dagneau, Paul D. O’Shea

Publikováno v: The Journal of Organic Chemistry. 68:2633-2638

A large-scale, chromatography-free synthesis of a potent and selective Cathepsin K inhibitor 1 is reported. The key asymmetric center was installed by addition of (R)-pantolactone to the in situ-generated ketene 4a. The final step of the convergent s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2095c7eeccb2bed53fbb935573722dff
https://doi.org/10.1021/jo0205614

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Efficient syntheses of 2-(3′,5′-difluorophenyl)-3-(4′-methylsulfonylphenyl)cyclopent-2-enone, a potent COX-2 inhibitor

Autor: Nathalie Ouimet, Feng Xu, Cameron Black, Paul J. Reider, Edward J. J. Grabowski, Peppi Prasit, R. D. Tillyer, Dalian Zhao, Cheng-yi Chen

Publikováno v: Tetrahedron. 55:6001-6018

2-(3′,5′-Difluorophenyl)-3-(4′-methylsulfonylphenyl)cyclopent-2-enone (1) displays high selectivity and potency against COX-2. Three efficient syntheses of this diarylcyclopentenone are described. The first approach employs a Suzuki coupling re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e654e9402b1cf57eae1262f172dbf45
https://doi.org/10.1016/s0040-4020(99)00274-4

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Enantioselective 1,4-addition of aryllithium reagents to α,β-unsaturated tert-butyl esters in the presence of chiral additives

Autor: R. D. Tillyer, Feng Xu, Edward J. J. Grabowski, Paul J. Reider, D. M. Tschaen

Publikováno v: Tetrahedron: Asymmetry. 9:1651-1655

Reaction of t-BuLi with a mixture of aryl bromide and chiral diamine, amino ether or diether, in toluene at −78°C provided chiral aryllithium complexes efficiently. Reaction of these aryllithium complexes with α,β-unsaturated tert-butyl esters a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cf02d0a675b77738108853af62afe4f
https://doi.org/10.1016/s0957-4166(98)00157-8

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Asymmetric reduction of keto oxime ethers using oxazaborolidine reagents. The enantioselective synthesis of cyclic amino alcohols

Autor: R. D. Tillyer, D. M. Tschaen, Charles Boudreau, Paul J. Reider, Ulf H. Dolling

Publikováno v: Tetrahedron Letters. 36:4337-4340

Asymmetric reduction of keto oxime ethers 2 catalyzed by oxazaborolidine-borane complex 4 produces the cis amino alcohols 1 efficiently and with high levels of diastereo- and enantioselectivity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cce7a57198926c0d3ea6f4f269bfebd
https://doi.org/10.1016/0040-4039(95)00788-e

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ChemInform Abstract: Asymmetric Reduction of Keto Oxime Ethers Using Oxazaborolidine Reagents. The Enantioselective Synthesis of Cyclic Amino Alcohols

Autor: Ulf H. Dolling, Paul J. Reider, D. M. Tschaen, R. D. Tillyer, Charles Boudreau

Publikováno v: ChemInform. 26

Asymmetric reduction of keto oxime ethers 2 catalyzed by oxazaborolidine-borane complex 4 produces the cis amino alcohols 1 efficiently and with high levels of diastereo- and enantioselectivity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33e6422d0a55c7ce11e787e9be5adba4
https://doi.org/10.1002/chin.199540117

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ChemInform Abstract: Enantioselective 1,4-Addition of Aryllithium Reagents to α,β-Unsaturated tert-Butyl Esters in the Presence of Chiral Additives

Autor: Feng Xu, D. M. Tschaen, Edward J. J. Grabowski, Paul J. Reider, R. D. Tillyer

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68653771fab665a1d37e12d588d9ae3e
https://doi.org/10.1002/chin.199840087

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