Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Autor: Jonathan P. Hutchinson, Paul Rowland, Mark R. D. Taylor, Erica M. Christodoulou, Carl Haslam, Clare I. Hobbs, Duncan S. Holmes, Paul Homes, John Liddle, Damian J. Mole, Iain Uings, Ann L. Walker, Scott P. Webster, Christopher G. Mowat, Chun-wa Chung

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Kynurenine-3-monooxygenase (KMO) is an emerging clinical target for treatment of neurodegenerative diseases and acute pancreatitis. Here, the authors report potent inhibitors that bind KMO in an unexpected conformation, offering structural and mechan

Externí odkaz: https://doaj.org/article/6a2d1e05cbf54050aa6e26f4834e4b9a

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Autor: Duncan S. Holmes, Paul Homes, Chun-wa Chung, Ann Louise Walker, Jonathan P. Hutchinson, Erica Christodoulou, John Liddle, Christopher G. Mowat, Scott P. Webster, Iain Uings, Carl Haslam, Clare I. Hobbs, Damian J. Mole, Paul Rowland, Mark R D Taylor

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Hutchinson, J P, Rowland, P, Taylor, M R D, Christodoulou, E M, Haslam, C, Hobbs, C M, Holmes, D, Homes, P, Liddle, J, Mole, D J, Uings, I J, Walker, A L, Webster, S P, Mowat, C & Chung, C 2017, ' Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase ', Nature Communications, vol. 8, 15827 . https://doi.org/10.1038/ncomms15827
Nature Communications
'Nature Communications ', vol: 8, pages: 15827-1-15827-12 (2017)

Kynurenine-3-monooxygenase (KMO) is a key FAD-dependent enzyme of tryptophan metabolism. In animal models, KMO inhibition has shown benefit in neurodegenerative diseases such as Huntington's and Alzheimer's. Most recently it has been identified as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7052eaed51497ed8d9f669cdc0a94bd
https://doaj.org/article/6a2d1e05cbf54050aa6e26f4834e4b9a

THE USE OF COLD STORAGE AS A SCHEDULING AID IN BEDDING PLANT PRODUCTION

Autor: W. Brough, J. Hill, Brian W. W. Grout, R. D. Taylor

Publikováno v: Acta Horticulturae. :147-154

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e2b5e16df12fe9ce867bdfb49bf70d6
https://doi.org/10.17660/actahortic.2009.847.18

Consequences of pressure-instigated spin crossover in R FeO 3 perovskites; a volume collapse with no symmetry modification

Autor: Stefan Carlson, R. D. Taylor, Leonid Dubrovinsky, W. M. Xu, Moshe P. Pasternak, G. Kh. Rozenberg

Publikováno v: Europhysics Letters (EPL). 71:228-234

High-pressure X-ray diffraction, Mossbauer, and Raman studies in the antiferromagnetic insulators RFeO3 orthorhombic perovskites (R = Pr, Eu, Lu) disclose an unusual phenomena of a reversible first-order isostructural phase transition around 50 GPa c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be84cc30a65466bc124290d18fcc9d55
https://doi.org/10.1209/epl/i2005-10071-9

Pressure-induced coordination crossover in magnetite, a high pressure Mössbauer study

Autor: R. D. Taylor, W. M. Xu, Raymond Jeanloz, Moshe P. Pasternak, G. Kh. Rozenberg

Publikováno v: Journal of Physics and Chemistry of Solids. 65:1531-1535

Temperature-dependent 57 Fe Mossbauer spectroscopy to 40 GPa shows that Fe3O4 magnetite undergoes a coordination crossover (CC) whereby charge-density is shifted from octahedral to tetrahedral sites and the spinel structure thus changes from inverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11d34ed55c1eb9c71a641c047f3d324f
https://doi.org/10.1016/j.jpcs.2003.12.013