Zobrazeno 1 - 10
of 38
pro vyhledávání: '"R. D. Farrant"'
Autor:
Elaine Holmes, Jeremy K. Nicholson, Williams A, Catherine J. Waterfield, Nigel J Waters, R D Farrant
Publikováno v:
Chemical Research in Toxicology. 14:1401-1412
We present here a novel integrative metabonomic approach to probe toxic effects of drugs in experimental animals using alpha-naphthylisothiocyanate (ANIT) as a model hepatotoxicant. Male Han-Wistar rats were dosed with ANIT (150 mg/kg, n = 25), and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfb3f4e2b6e7d5931a99f2edb15ebba
https://doi.org/10.1021/tx010067f
https://doi.org/10.1021/tx010067f
Autor:
Stephen J. P. Damment, John P. Shockcor, John C. Lindon, John N. Haselden, Catherine J. Waterfield, R D Farrant, Elaine Holmes, Jeremy K. Nicholson, Andrew W. Nicholls
Publikováno v:
Chemical Research in Toxicology. 14:975-987
The systemic biochemical effects of oral hydrazine administration (dosed at 75, 90, and 120 mg/kg) have been investigated in male Han Wistar rats using metabonomic analysis of (1)H NMR spectra of urine and plasma, conventional clinical chemistry, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510683467e16b0cfa1afd244fb608fe0
https://doi.org/10.1021/tx000231j
https://doi.org/10.1021/tx000231j
Publikováno v:
Journal of Biological Chemistry. 276:15107-15116
We previously identified vitamin B6 deficiency in a child presenting with seizures whose primary diagnosis was the inherited disorder hyperprolinemia type II. This is an unrecognized association, which was not explained by diet or medication. We hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bbb51cf76e2401f4abd90cfae5e4588
https://doi.org/10.1074/jbc.m010860200
https://doi.org/10.1074/jbc.m010860200
Autor:
Ismail M. Ismail, R. D. Farrant, Maili Liu, John C. Lindon, Nisha Mistry, Jeremy K. Nicholson
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 19:511-517
The impurity profile of production batches of fluorine-containing drugs can be characterised efficiently using F-19 NMR spectroscopy. This yields the number and proportions of impurities in the bulk drug to a level of approximate to 0.1 mole% in a fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ae48ee5803e1e668eaa386dd8a555a
https://doi.org/10.1016/s0731-7085(98)00247-7
https://doi.org/10.1016/s0731-7085(98)00247-7
Autor:
R. D. Farrant, Marcello Longeri, John C. Lindon, Marina Carravetta, Franca Castiglione, David L. Turner, E. K. Foord, W.E. Palke, G. De Luca, Mark Edgar, J. W. Emsley
Publikováno v:
Journal of Magnetic Resonance. 135:298-309
It is demonstrated that the NMR spectra of liquid crystalline samples can be simplified by using multiple quantum filtering. In a system of N spin- 1 2 nuclei, the N or (N-1)-multiple quantum filtered spectra (NQF or (N-1)QF) contain lines which orig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d23653c0ceeb4674466a0cf03c1a09
https://doi.org/10.1006/jmre.1998.1574
https://doi.org/10.1006/jmre.1998.1574
Publikováno v:
Spectroscopy Letters. 31:269-274
The 13C NMR spectra of a series of N-acyl six-member ring nitrogen heterocycles have been measured as a function of temperature and the results interpreted in terms of restricted amide rotation and ring inversion. Slow rotation is observed on the NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e41765689fb56023fc11a260d81784aa
https://doi.org/10.1080/00387019808003251
https://doi.org/10.1080/00387019808003251
Autor:
R. D. Farrant, John P. Shockcor, John C. Lindon, Paul N. Sanderson, L W Frick, R M Wurm, B. C. Sweatman
Publikováno v:
Xenobiotica. 26:189-199
1. Human urine samples from a clinical trial of the anti-HIV compound (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-cyto sin e (BW524W91) have been analysed using 19F-nmr and 1H-hplc-nmr spectroscopy. 2. The identities and relative level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba19d36b483e35168cdb8f7486bbc55d
https://doi.org/10.3109/00498259609046699
https://doi.org/10.3109/00498259609046699
Autor:
R. D. Farrant, John C. Lindon, Martin Hofmann, S. L. Gough, Manfred Spraul, Jeremy K. Nicholson, Paul N. Sanderson, P. M. Doyle
Publikováno v:
Magnetic Resonance in Chemistry. 33:857-863
The efficiency of directly coupled HPLC—NMR spectroscopy for the separation and characterization of synthetic peptide libraries was investigated using a model system based on a mixture of all 27 tripeptide combinations of alanine (A), methionine (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aaac4431b87e4eafa86e370d558ab26
https://doi.org/10.1002/mrc.1260331103
https://doi.org/10.1002/mrc.1260331103
Autor:
R. D. Farrant, Jeremy K. Nicholson, Manfred Spraul, Ian D. Wilson, John C. Lindon, Andrew W. Nicholls
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 13:971-977
Many drugs containing carboxylic acid functional groups are metabolised in vivo to ester glucuronides (1-O-acyl-β- d -glucopyranuronates) and, of these, a number show a propensity to undergo internal isomerisation via a transacylation process, causi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e4867acf223ce27030e18e43d169d1
https://doi.org/10.1016/0731-7085(95)01551-u
https://doi.org/10.1016/0731-7085(95)01551-u
Publikováno v:
Journal of Magnetic Resonance, Series A. 113:251-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2734dc9b52427e1231e79da5ed30537
https://doi.org/10.1006/jmra.1995.1089
https://doi.org/10.1006/jmra.1995.1089