Zobrazeno 1 - 10
of 26
pro vyhledávání: '"R. D. Brownsill"'
Publikováno v:
Xenobiotica. 26:221-228
1. The objective was to use modern mass spectrometric techniques to update current information on the metabolism of trimetazidine in human subjects found by previous studies. 2. Urine and plasma samples were taken from four healthy human volunteers t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152d0fb32f36d371ec650344d1370bad
https://doi.org/10.3109/00498259609046702
https://doi.org/10.3109/00498259609046702
Publikováno v:
Journal of Mass Spectrometry. 30:446-451
The application of liquid chromatography/mass spectrometry (LC/MS) and LC/MS/MS with electrospray ionization to drug metabolism studies was investigated using S 9788 and various synthesized metabolic products as model compounds to assess the response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81241ba582aad8e7c496c782069b0ef0
https://doi.org/10.1002/jms.1190300308
https://doi.org/10.1002/jms.1190300308
Autor:
A R, Taylor, R D, Brownsill, H, Grandon, F, Lefoulon, A, Petit, W, Luijten, P G, Kopelman, B, Walther
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(1)
Synthesis of postulated hydroxylated metabolites of gliclazide is described together with their detailed structural analysis using 1H-NMR, two-dimensional 1H-NMR, and MS to characterize the products. Metabolism of gliclazide has been investigated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de9eb4366a511f95a5df11f88286b3d4
https://pubmed.ncbi.nlm.nih.gov/8825191
https://pubmed.ncbi.nlm.nih.gov/8825191
Autor:
D. A. Rose, A. Barrow, P. N. Spalton, R. D. Brownsill, Y. Gunn, C. M. Walls, N. J. Haskins, R. F. Palmer
Publikováno v:
Xenobiotica. 10:219-228
1. The disposition of [14C]pranolium chloride, a dimethyl quaternary derivative of propranolol, has been studied in rats, mice and hamsters after oral or parenteral dosage.2. Elimination of 14C occurred largely via the kidneys after parenteral dosage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114b595043a2cb6f90b32a1883fc8cfa
https://doi.org/10.3109/00498258009033748
https://doi.org/10.3109/00498258009033748
Autor:
JR Shelton, E. F. Allan, Joan M Clarke, R. D. Brownsill, N. J. Haskins, R. F. Palmer, RM Perkins, A. J. Hawkins, G. C. Ford, Ian R Harrison, C. W. Vose, G. V. Rigby
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 8:219-224
To determine the comparative bioavailability of three oral formulations of propantheline bromide (PB) by both pharmacokinetic and pharmacodynamic parameters, six normal men received three standard Pro-Banthine 15 mg tablets, two prolonged acting (PA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e292772e998995434604db7a807b896a
https://doi.org/10.1007/bf03188751
https://doi.org/10.1007/bf03188751
Publikováno v:
Xenobiotica. 18:1413-1423
1. 14C-Bemitradine (50 mg) was rapidly and efficiently absorbed (approximately 89%) in man following a single oral dose, as a solution in gelatine capsules. Peak 14C levels of 895 +/- 154 ng equiv./ml (mean +/- S.E.M.) were reached within 2 h, and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfa9b88f9ee4d9ec76bf3282f4e4d7b
https://doi.org/10.3109/00498258809042264
https://doi.org/10.3109/00498258809042264
Publikováno v:
Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular ISBN: 9781475794267
Mass spectrometry (MS) is widely applied to the identification of drug metabolites isolated from biological fluids. A wide range of techniques are available, e.g. GC-MS and LC-MS where the MS options include electron-impact (EI), chemical ionization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b5bf8305fed6c4b6eac018063e91a55
https://doi.org/10.1007/978-1-4757-9424-3_50
https://doi.org/10.1007/978-1-4757-9424-3_50
Autor:
A. Mcallister, R. D. Brownsill, J. E. H. Stafford, C. W. Vose, Norma Gerry, J. A. Steiner, M. P. Hiley, D. A. Rose
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 17(11)
1. In 12 healthy subjects, after single doses of 20, 40 and 80 mg of nufenoxole, mean peak plasma drug concentrations of 400, 815 and 1463 ng/ml were reached at 2.2, 2.5 and 2.5 h respectively. 2. Nufenoxole was absorbed with an apparent half-life of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c5bbb538085356bb23c21febce1d1a
https://pubmed.ncbi.nlm.nih.gov/3433806
https://pubmed.ncbi.nlm.nih.gov/3433806
Publikováno v:
Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular ISBN: 9781475794267
Hydroxylation is probably the most common Phase I metabolic pathway for xenobiotics. It is also a pathway readily detectable by MS from the 16 a.m.u. mass shift for the metabolite ions relative to those of the parent compound. However, such informati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cf334bf3c784dfffbb847815d8e4429
https://doi.org/10.1007/978-1-4757-9424-3_51
https://doi.org/10.1007/978-1-4757-9424-3_51
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 17(10)
1. After oral administration of 3H-enisoprost (450 micrograms) to five healthy men, as a solution in capsules, peak 3H levels of 5624 +/- 566 pg equiv./ml (mean +/- S.E.M.) were reached within one hour. No unchanged drug was detected in plasma. 2. En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4891364907793d60c8c8a9d5e73349e8
https://pubmed.ncbi.nlm.nih.gov/3424870
https://pubmed.ncbi.nlm.nih.gov/3424870