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Akademický článek

Relationships between genomic dissipation and de novo SNP evolution.

Autor: Zackery E Plyler, Christopher W McAtee, Aubrey E Hill, Michael R Crowley, Janice M Tindall, Samuel R Tindall, Disha Joshi, Eric J Sorscher

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0303257 (2024)

Patterns of single nucleotide polymorphisms (SNPs) in eukaryotic DNA are traditionally attributed to selective pressure, drift, identity descent, or related factors-without accounting for ways in which bias during de novo SNP formation, itself, might

Externí odkaz: https://doaj.org/article/9af081f218c24a57bacb27a06f5326c0

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Akademický článek

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG

Autor: Andrew R. Crowley, Matthew R. Mehlenbacher, Mohammad M. Sajadi, Anthony L. DeVico, George K. Lewis, Margaret E. Ackerman

Publikováno v: mAbs, Vol 15, Iss 1 (2023)

ABSTRACTAntibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from f

Externí odkaz: https://doaj.org/article/5559437caf7c436bac7eade70d7f9afd

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Akademický článek

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

Publikováno v: JCI Insight, Vol 8, Iss 19 (2023)

The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area of research. In this study, we determined that ST6 β-galactoside α2,6 sialyltransferase 1 (ST6GAL1), which adds α2,6-linked sialic aci

Externí odkaz: https://doaj.org/article/8d74b6365a7e4f5aab8310300004ced9

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Akademický článek

Radiopharmaceutical administration practices—Are they best practice?

Autor: Stephen Harris, James R. Crowley, Nancy Warden

Publikováno v: Frontiers in Nuclear Medicine, Vol 3 (2023)

BackgroundThe nuclear medicine community has stated that they are using best practices to gain venous access and administer radiopharmaceuticals, and therefore do not contribute to extravasations. We tested this hypothesis qualitatively and quantitat

Externí odkaz: https://doaj.org/article/d22cacd17d184ba692ad3ec49d38b69a

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Akademický článek

Dual RNA sequencing of group B Streptococcus-infected human monocytes reveals new insights into host–pathogen interactions and bacterial evasion of phagocytosis

Autor: Matthew J. Sullivan, Darren Prince, Kelvin G. K. Goh, Lahiru Katupitiya, Dean Gosling, Michael R. Crowley, David K. Crossman, Glen C. Ulett

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)

Abstract Streptococcus agalactiae, also known as Group B Streptococcus (GBS) is a frequent cause of infections, including bacteraemia and other acute diseases in adults and immunocompromised individuals. We developed a novel system to study GBS withi

Externí odkaz: https://doaj.org/article/ba104a9df20644099df98bfad98b3b28

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Akademický článek

Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse

Autor: Rudradip Pattanayak, Rachel Underwood, Michael R. Crowley, David K. Crossman, Jennifer R. Morgan, Talene A. Yacoubian

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract We report an incidental 358.5 kb deletion spanning the region encoding for alpha-synuclein (αsyn) and multimerin1 (Mmrn1) in the Rab27a/Rab27b double knockout (DKO) mouse line previously developed by Tolmachova and colleagues in 2007. Weste

Externí odkaz: https://doaj.org/article/8bd287e7d97b4036b0fcad4eede32b48

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