Zobrazeno 1 - 10
of 93
pro vyhledávání: '"R. Collette"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The clinical management of metastatic urothelial carcinoma has significantly evolved with the emergence of monoclonal antibodies and antibody-drug conjugates (ADCs). Enfortumab vedotin (EV) was granted approval by the FDA in 2021 for patients with lo
Externí odkaz:
https://doaj.org/article/806d3f41a0b94793a7f51fdec3362849
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Candida species are a leading cause of opportunistic, hospital-associated bloodstream infections with high mortality rates, typically in immunocompromised patients. Several species, including Candida albicans, the most prevalent cause of inf
Externí odkaz:
https://doaj.org/article/c406d6b66d4a4a9b8be664b1f95c9668
Publikováno v:
Microscopy and Microanalysis. 27:2156-2158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1fb186d112d594b6aebfd6869c3372
https://doi.org/10.1017/s1431927621007777
https://doi.org/10.1017/s1431927621007777
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e96203 (2014)
Macrophages and neutrophils generate a potent burst of reactive oxygen and nitrogen species as a key aspect of the antimicrobial response. While most successful pathogens, including the fungus Candida albicans, encode enzymes for the detoxification o
Externí odkaz:
https://doaj.org/article/ee33c24799444d598463e15b432650f3
Publikováno v:
Proc Natl Acad Sci U S A
The failure of polypeptides to achieve conformational maturation following biosynthesis can result in the formation of protein aggregates capable of disrupting essential cellular functions. In the secretory pathway, misfolded asparagine (N)-linked gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4466a4b3788d9ee7c45b94d517b96e56
https://pubmed.ncbi.nlm.nih.gov/32958677
https://pubmed.ncbi.nlm.nih.gov/32958677
Autor:
Richard N. Sifers, Carolyn J. Adamski, Antrix Jain, Kaifang Pang, J. Lloyd Holder, Sung Yun Jung, Huda Y. Zoghbi, Zhandong Liu, Li Wang, Vitaliy V. Bondar, Evelyn Craigen, John R. Collette, Kihoon Han
Publikováno v:
Molecular psychiatry
Neurons are sensitive to changes in the dosage of many genes, especially those regulating synaptic functions. Haploinsufficiency of SHANK3 causes Phelan-McDermid syndrome and autism, whereas duplication of the same gene leads to SHANK3 duplication sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f297bd3958c8de78c2b31cd2a33eae
https://doi.org/10.1038/s41380-018-0325-9
https://doi.org/10.1038/s41380-018-0325-9
Autor:
Slavena Vylkova, Aaron J. Carman, Heather A. Danhof, John R. Collette, Huaijin Zhou, Michael C. Lorenz
Publikováno v:
mBio, Vol 2, Iss 3 (2011)
ABSTRACT pH homeostasis is critical for all organisms; in the fungal pathogen Candida albicans, pH adaptation is critical for virulence in distinct host niches. We demonstrate that beyond adaptation, C. albicans actively neutralizes the environment f
Externí odkaz:
https://doaj.org/article/b5f598c3325045c9894e49f3763a387a
Autor:
Marco Sardiello, Rui Chen, Alberto di Ronza, John R. Collette, Aiden Eblimit, Jaiprakash Sharma, Dany Roman, Sung Yun Jung, Richard N. Sifers, Randy Schekman, Lakshya Bajaj, Rituraj Pal, Pengcheng Zheng
Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and transferred to the Golgi complex by interaction with the Batten disease protein CLN8. Here we investigated the relationship of this pathway with CLN6, an ER-associated protein of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27a285efc053b8bea8f283b8e78db39
Autor:
Alberto di Ronza, Pengcheng Zhang, Lakshya Bajaj, Dany Roman, Rituraj Pal, Sung Yun Jung, Jill M. Weimer, Jaiprakash Sharma, Rui Chen, Marco Sardiello, Richard N. Sifers, Randy Schekman, John R. Collette, Aiden Eblimit, Clarissa D. Booth, Kevin T. Chang
Publikováno v:
J Clin Invest
Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and transferred to the Golgi complex by interaction with the Batten disease protein CLN8 (ceroid lipofuscinosis, neuronal, 8). Here we investigated the relationship of this pathway w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a639bfd77e1431c8bb7489b13e2117
https://pubmed.ncbi.nlm.nih.gov/32597833
https://pubmed.ncbi.nlm.nih.gov/32597833