Zobrazeno 1 - 10 of 312 pro vyhledávání: '"R. Cecchelli"'
1
Akademický článek
Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood–brain barrier endothelial cells in vitro
Autor: N. Bernoud, L. Fenart, C. Bénistant, J.F. Pageaux, M.P. Dehouck, P. Molière, M. Lagarde, R. Cecchelli, J. Lecerf
Publikováno v: Journal of Lipid Research, Vol 39, Iss 9, Pp 1816-1824 (1998)
To determine the respective roles of endothelial cells from brain capillaries and astrocytes in the conversion of circulating 18:2n–6 and 18:3n–3 into 20:4n–6 and 22:6n–3, respectively, a coculture of the two cell types mimicking the in vivo
Externí odkaz: https://doaj.org/article/4f5bcfa2da8f471ca47699612f8171f7
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2
A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier
Autor: Emmanuel Sevin, Stefan Martinsson, Stefan Lundquist, Maxime Culot, Erica Szorath, Anaelle da Costa, Yan Hongmei, Mila Renftel, R. Cecchelli
Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (12), pp.e80634. ⟨10.1371/journal.pone.0080634⟩
PLoS ONE, Vol 8, Iss 12, p e80634 (2013)
International audience; Historically, the focus has been to use in vitro BBB models to optimize rate of drug delivery to the CNS, whereas total in vivo brain/plasma ratios have been used for optimizing extent. However, these two parameters do not nec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86c385cb5c608e1e225ea0f7276d3a8
https://hal-univ-artois.archives-ouvertes.fr/hal-02515332
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3
Endothelial calcium dynamics, connexin channels and blood–brain barrier function
Autor: Mélissa Bol, Elke Decrock, R. Cecchelli, Maxime Culot, Nan Wang, Ashish K. Gadicherla, Luc Leybaert, Geert Bultynck, Marijke De Bock
Publikováno v: Progress in Neurobiology
Progress in Neurobiology, Elsevier, 2013, 108, pp.1-20. ⟨10.1016/j.pneurobio.2013.06.001⟩
International audience; Situated between the circulation and the brain, the blood-brain barrier (BBB) protects the brain from circulating toxins while securing a specialized environment for neuro-glial signaling. BBB capillary endothelial cells exhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa08c74e055bebb6cbf3fbdd12dedb1
https://hal-univ-artois.archives-ouvertes.fr/hal-02515498
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4
In vitro blood–brain barrier model adapted to repeated-dose toxicological screening
Autor: C. Landry, R. Aijjou, Maxime Culot, R. Cecchelli, A. Fabulas-da Costa, Johan Hachani
Publikováno v: Toxicology in Vitro
Toxicology in Vitro, Elsevier, 2013, 27 (6), pp.1944-1953. ⟨10.1016/j.tiv.2013.06.026⟩
Toxicology in Vitro; Vol 27
International audience; Toxicity to the central nervous system (CNS) is a key feature in the toxicological profile of compounds and there is a growing interest to use in vitro cell assays. The blood-brain barrier (BBB) is a highly restrictive barrier
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3dd0ef207a7b73414bdf87a90098b6
https://hal-univ-artois.archives-ouvertes.fr/hal-02515342
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5
The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox
Autor: Agnieszka Kinsner-Ovaskainen, C. Landry, Guadalupe Herrera, L. Gombau, José-Enrique O'Connor, Pilar Prieto, Per Artursson, M. J. Zurbano, E. Di Consiglio, Sven Stanzel, Marie-Gabrielle Zurich, Guillermo Quintás, Lilián Díaz, Laura Turco, Angela Guerra, B. Albella, Richard Svensson, Paul Honegger, Annette Kopp-Schneider, Nuria E. Campillo, L. Cerrato, Juan A. Páez, R. Cecchelli
Publikováno v: Toxicology in Vitro
Toxicology in Vitro, Elsevier, 2013, 27 (4), pp.1357-1376. ⟨10.1016/j.tiv.2012.07.013⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
TOXICOLOGY IN VITRO
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
ACuteTox is a project within the 6th European Framework Programme which had as one of its goals to develop, optimise and prevalidate a non-animal testing strategy for predicting human acute oral toxicity. In its last 6months, a challenging exercise w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b754f16410dccd2173de6fdd25b277f3
https://hal-univ-artois.archives-ouvertes.fr/hal-02515626
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6
Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: A differential gel electrophoresis study
Autor: Philippe Chafey, Cédric Broussard, Yannis Karamanos, Barbara Deracinois, Gwënaël Pottiez, Luc Camoin, Tom Teerlink, Pierre-Olivier Couraud, R. Cecchelli, Christophe Flahaut, Mariska Davids, Marie-Pierre Dehouck
Publikováno v: Proteomics
Proteomics, Wiley-VCH Verlag, 2013, 13 (7), pp.1185-1199. ⟨10.1002/pmic.201200166⟩
Journal of Proteomics, 13(7), 1185-1199. Elsevier
Deracinois, B, Pottiez, G, Chafey, P, Teerlink, T, Camoin, L, Davids, M, Broussard, C, Couraud, P O, Dehouck, M P, Cecchelli, R, Karamanos, Y & Flahaut, C 2013, ' Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: A differential gel electrophoresis study ', Journal of Proteomics, vol. 13, no. 7, pp. 1185-1199 . https://doi.org/10.1002/pmic.201200166
PROTEOMICS; Vol 13
PROTEOMICS
International audience; In the neurovascular unit, brain microvascular endothelial cells develop characteristic barrier features that control the molecular exchanges between the blood and the brain. These characteristics are partially or totally lost
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af830746f17660dcb109e1b7d12b9b7e
https://hal-univ-artois.archives-ouvertes.fr/hal-02515850
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7
Fatty acid composition of brain capillary endothelial cells: effect of the coculture with astrocytes
Autor: Michel Lagarde, M P Dehouck, R Cecchelli, C Bénistant, J.-C. Fruchart
Publikováno v: Journal of Lipid Research, Vol 36, Iss 11, Pp 2311-2319 (1995)
The Journal of Lipid Research
The Journal of Lipid Research, 1995, 36, p. 2311-2319
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 1995, 36, p. 2311-2319
International audience; We have investigated the fatty acid composition of brain capillary endothelial cells cultured alone or in coculture with astrocytes, using an in vitro model in which endothelial cells and astrocytes were grown from one part of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec650917cb699828a2692918e11bafe3
http://www.sciencedirect.com/science/article/pii/S0022227520397121
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8
Increased transendothelial permeability of anti-cancer agent carboplatin with the aid of hyperbaric oxygenation
Autor: S Nion, Norie Murayama, Hiroshi Yamazaki, Makiko Shimizu, K Tanaka, R Cecchelli
Publikováno v: Xenobiotica
Xenobiotica, Taylor & Francis, 2008, 38 (10), p. 1298-1304
International audience; 1. The objective was to investigate the transport of an anticancer agent carboplatin across the blood-brain barrier in combination with hyperbaric oxygenation treatment. An in vitro well-validated model of bovine brain capilla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca78d7fbb0f86b0332bf1e4131d4403a
https://hal-univ-artois.archives-ouvertes.fr/hal-00543660
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10
Fatty acid composition of brain capillary endothelial cells: effect of the coculture with astrocytes
Autor: C, Bénistant, M P, Dehouck, J C, Fruchart, R, Cecchelli, M, Lagarde
Publikováno v: Journal of lipid research. 36(11)
We have investigated the fatty acid composition of brain capillary endothelial cells cultured alone or in coculture with astrocytes, using an in vitro model in which endothelial cells and astrocytes were grown from one part of a filter to another. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b828b2a57498e5e224f2aea23debc816
https://pubmed.ncbi.nlm.nih.gov/8656069
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