Zobrazeno 1 - 10
of 259
pro vyhledávání: '"R. Castilho"'
Autor:
Thayana A. Cruz, Nicholas R. Larson, Yangjie Wei, Natalia Subelzu, Yaqi Wu, Christian Schöneich, Leda R. Castilho, Charles Russell Middaugh
Publikováno v:
Biologics, Vol 4, Iss 3, Pp 294-313 (2024)
During early development of biopharmaceuticals, suboptimal producing clones and production conditions can result in limited quantities of high-purity products. Here we describe a systematic approach, which requires minimal amounts of protein (~10 mg)
Externí odkaz:
https://doaj.org/article/4ce9af17cf744b2d9eec9bbc902b6693
Autor:
Camila A Corsini, Priscilla S Filgueiras, Nathalie BF Almeida, Daniel AP de Miranda, Sarah VC Gomes, Adelina Junia Lourenço, Cecilia MF Bicalho, Jessica V de Assis, Raquel NH Amorim, Raphael A Silva, Raquel VR Vilela, Tulio M Lima, Daniel PB de Abreu, Renata GF Alvim, Leda R Castilho, Olindo A Martins-Filho, Dayane A Otta, Rafaella FQ Grenfell
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The COVID-19 pandemic has caused a severe global health and economic crisis, with significant consequences for human mortality and morbidity. Therefore, there is an urgent need for more studies on the immune response to SARS-CoV-2 infection,
Externí odkaz:
https://doaj.org/article/485acd06585e4046b792216b035aa2a4
Publikováno v:
Biologics, Vol 2, Iss 4, Pp 226-242 (2022)
Flaviviruses, such as dengue, zika, yellow fever, West Nile, and Japanese encephalitis virus, are RNA viruses belonging to the Flaviviridae family (genus Flavivirus). They represent an important global health concern, since most areas of the world ar
Externí odkaz:
https://doaj.org/article/6453f098f3de4699bd608b8eb4f5dcc6
Autor:
Momtchilo Russo, Maria Cássia Mendes-Corrêa, Bruna B. Lins, Victor Kersten, Paulo C. A. Pernambuco Filho, Toni Ricardo Martins, Tânia Regina Tozetto-Mendoza, Lucy Santos Vilas Boas, Brisa Moreira Gomes, Livia Mendonça Munhoz Dati, Amaro Nunes Duarte-Neto, Gustavo Roncoli Reigado, Ana Beatriz T. Frederico, Danielle R. de A. de Brito e Cunha, Anderson Vicente de Paula, José Igor G. da Silva, Carlos F. Moreira Vasconcelos, Felipe S. Chambergo, Viviane Abreu Nunes, Ana Paula Dinis Ano Bom, Leda R. Castilho, Rodrigo A. P. Martins, Mario Hiroyuki Hirata, Luciana Mirotti
Publikováno v:
Vaccines, Vol 11, Iss 11, p 1732 (2023)
Mucosal vaccination appears to be suitable to protect against SARS-CoV-2 infection. In this study, we tested an intranasal mucosal vaccine candidate for COVID-19 that consisted of a cationic liposome containing a trimeric SARS-CoV-2 spike protein and
Externí odkaz:
https://doaj.org/article/24684303e25545469a8f09b79540fc5b
Autor:
Hiam R.S. Arruda, Tulio M. Lima, Renata G.F. Alvim, Fernanda B.A. Victorio, Daniel P.B. Abreu, Federico F. Marsili, Karen D. Cruz, Mayra A. Marques, Patricia Sosa-Acosta, Mauricio Quinones-Vega, Jéssica de S. Guedes, Fábio C.S. Nogueira, Jerson L. Silva, Leda R. Castilho, Guilherme A.P. de Oliveira
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105696- (2023)
Summary: The severe acute respiratory syndrome spread worldwide, causing a pandemic. SARS-CoV-2 mutations have arisen in the spike, a glycoprotein at the viral envelope and an antigenic candidate for vaccines against COVID-19. Here, we present compar
Externí odkaz:
https://doaj.org/article/082a714a76334ef283c20689581f07d8
Akademický článek
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Autor:
Rafaella F. Q. Grenfell, Nathalie B. F. Almeida, Priscilla S. Filgueiras, Camila A. Corsini, Sarah V. C. Gomes, Daniel A. P. de Miranda, Adelina J. Lourenço, Olindo A. Martins-Filho, Jaquelline G. de Oliveira, Andrea Teixeira-Carvalho, Guilherme R. F. Campos, Mauricio L. Nogueira, Pedro Augusto Alves, Gabriel R. Fernandes, Leda R. Castilho, Tulio M. Lima, Daniel P. B. de Abreu, Renata G. F. Alvim, Thaís Bárbara de S. Silva, Wander de J. Jeremias, Dayane A. Otta, Ana Carolina Campi-Azevedo, Immunita-001 Team, Priscila Fernanda S Martins, Maria Luysa C Pedrosa, Jessica V de Assis, Viviane CF dos Santos, Eduardo R de Oliveira, Raphael A Silva, Maria Izabella VARC Medeiros, Rafaela OV Coelho, Cecilia MF Bicalho, Raquel VR Vilela
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundEffective and safe vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are critical to controlling the COVID-19 pandemic and will remain the most important tool in limiting the spread of the virus long after the pa
Externí odkaz:
https://doaj.org/article/1ea09f5e8d8d44b49fc0a9401610d309
Autor:
Luis Eduardo R. Cunha, Adilson A. Stolet, Marcelo A. Strauch, Victor A.R. Pereira, Carlos H. Dumard, Andre M.O. Gomes, Fábio L. Monteiro, Luiza M. Higa, Patrícia N.C. Souza, Juliana G. Fonseca, Francisco E. Pontes, Leonardo G.R. Meirelles, José W.M. Albuquerque, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Tulio M. Lima, Renata G.F. Alvim, Federico F. Marsili, Marcella Moreira Caldeira, Russolina B. Zingali, Guilherme A.P. de Oliveira, Thiago M.L. Souza, Alexandre S. Silva, Rodrigo Muller, Daniela del Rosário Flores Rodrigues, Luciana Jesus da Costa, Arthur Daniel R. Alves, Marcelo Alves Pinto, Andréa C. Oliveira, Herbert L.M. Guedes, Amilcar Tanuri, Leda R. Castilho, Jerson L. Silva
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103315- (2021)
Summary: We used the recombinant trimeric spike (S) glycoprotein in the prefusion conformation to immunize horses for the production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by ELISA were above 1:106, and the neutra
Externí odkaz:
https://doaj.org/article/fd393a9b9edf40629a376603a387320c
Autor:
Ahmed S. Fahad, Morgan R. Timm, Bharat Madan, Katherine E. Burgomaster, Kimberly A. Dowd, Erica Normandin, Matías F. Gutiérrez-González, Joseph M. Pennington, Matheus Oliveira De Souza, Amy R. Henry, Farida Laboune, Lingshu Wang, David R. Ambrozak, Ingelise J. Gordon, Daniel C. Douek, Julie E. Ledgerwood, Barney S. Graham, Leda R. Castilho, Theodore C. Pierson, John R. Mascola, Brandon J. DeKosky
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The re-emergence of Zika virus (ZIKV) caused widespread infections that were linked to Guillain-Barré syndrome in adults and congenital malformation in fetuses, and epidemiological data suggest that ZIKV infection can induce protective antibody resp
Externí odkaz:
https://doaj.org/article/f95e6840712f42789ca64171182a652b
Autor:
Angelita C. MELO, Alice R. SILVA, Mario J. SOBREIRA-DA-SILVA, Renata C. NASCIMENTO, Fernando FERNANDEZ-LLIMOS, Antonio M. MENDES, Catarina L. OLIVEIRA, Cesar A. TEIXEIRA, Claudia G. OSORIO-DE-CASTRO, Débora DE CARVALHO, Eugenie D. NERI, Fabio FERRACINI, Javier A. CRIADO, Lucila I. CASTRO-PASTRANA, Luciane F. CALDEIRA, Pamela BERTOLDO, Rodrigo ORELLANA, Selma R. CASTILHO, Simone D. MAHMUD, Teresa HERNÁNDEZ-GALINDO, Valéria S. BEZERRA, Valdjane SALDANHA, Vanusa B. PINTO, Elisangela C. LIMA
Publikováno v:
Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 11, Iss 4 (2020)
Externí odkaz:
https://doaj.org/article/2246b373f8df4e71bc6dd2b1dd0ed7dc