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Akademický článek

The predictive and prognostic role of single nucleotide gene variants of PD-1 and PD-L1 in patients with advanced melanoma treated with PD-1 inhibitors

Autor: A. Boutros, R. Carosio, D. Campanella, F. Spagnolo, B. Banelli, A. Morabito, M.P. Pistillo, E. Croce, F. Cecchi, P. Pronzato, P. Queirolo, E. Raposio, V. Fontana, E.T. Tanda

Publikováno v: Immuno-Oncology and Technology, Vol 20, Iss , Pp 100408- (2023)

Background: Despite having revolutionized the treatment paradigm for advanced melanoma, not all patients benefit from immune checkpoint inhibitor therapy. To date, there are no predictive biomarkers for response or the occurrence of immune-related ad

Externí odkaz: https://doaj.org/article/5f6042a2cc5041439f7d2b2d81fb1fc3

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Akademický článek

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24P The predictive and prognostic role of single nucleotide gene variants in PD-1 and PD-L1 in patients with advanced melanoma treated with PD-1 inhibitors

Autor: A. Boutros, R. Carosio, D. Campanella, F. Spagnolo, B. Banelli, A. Morabito, M.P. Pistillo, E. Croce, F. Cecchi, P. Pronzato, P. Queirolo, V. Fontana, E.T. Tanda

Publikováno v: Immuno-Oncology and Technology. 16:100129

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1d7553bfdb1aa90a27b2f92047465fa
https://doi.org/10.1016/j.iotech.2022.100129

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Akademický článek

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Fenretinide-polyvinylalcohol Conjugates: New Systems Allowing Fenretinide Intravenous Administration

Autor: Roberto Gotti, Paolo G. Montaldo, Valentina Bergamante, Isabella Orienti, Michele Cilli, R. Carosio, Guendalina Zuccari

Publikováno v: Biomacromolecules. 8:3258-3262

N-(4-hydroxyphenyl)retinamide (fenretinide, 4-HPR) has been shown to be active toward many tumors without appreciable side effects. However its in vitro activity does not match a correspondent efficacy in vivo. The main reason is that the drug's hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb42b6646052c977d4e13089a24e90a
https://doi.org/10.1021/bm7005592

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Enhanced anti-neuroblastoma activity of a fenretinide complexed form after intravenous administration

Autor: Isabella Orienti, Franca Formelli, Salvatore Mangraviti, Paolo G. Montaldo, Laura Emionite, R. Carosio, Elena Cavadini, Emanuela Ognio, Guendalina Zuccari, Vito Pistoia

Publikováno v: Journal of Pharmacy and Pharmacology. 64:228-236

Objectives The major limitation to successful chemotherapy of neuroblastoma (NB) is the toxicity and the poor bioavailability of traditional drugs. Methods We synthesised an amphiphilic dextrin derivative (DX-OL) able to host fenretinide (4-HPR) by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec704b0bd184579880bba2a5bbc3fb0
https://doi.org/10.1111/j.2042-7158.2011.01403.x

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Improvement of aqueous solubility of fenretinide and other hydrophobic anti-tumor drugs by complexation with amphiphilic dextrins

Autor: Guendalina Zuccari, Paolo G. Montaldo, Isabella Orienti, R. Carosio

Publikováno v: Drug Delivery. 16:389-398

This study relates to the preparation of a series of amphiphilic dextrins and their evaluation as complexing agents for anti-tumor hydrophobic drugs such as fenretinide, paclitaxel, etoposide, and camptothecin. The amphiphilic dextrins were obtained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8026f5953b4481eb7b1fa328b8b50f26
https://doi.org/10.1080/10717540903101655

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The Combined Therapeutic Effects of Bortezomib and Fenretinide on Neuroblastoma Cells Involve Endoplasmic Reticulum Stress Response

Autor: Domenico Ribatti, Annalisa Pezzolo, Vito Pistoia, Beatrice Nico, Chiara Brignole, R. Carosio, Fabio Pastorino, Mirco Ponzoni, Federica Piccardi, Michele Cilli, Daniela Di Paolo, Monica Loi, Gabriella Pagnan, Danilo Marimpietri, Luis J. V. Galietta

Publikováno v: Clinical Cancer Research. 15:1199-1209

Purpose: The proteasome inhibitor bortezomib inhibited cell growth and angiogenesis in neuroblastoma. Bortezomib has been shown to induce synergistic activity when combined with other antineoplastic agents. Here we have investigated the antitumor act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec055217423a7610bfad54bad16cab0e
https://doi.org/10.1158/1078-0432.ccr-08-2477

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Preparation and Evaluation of Polyvinyl alcohol-co-oleylvinyl ether Derivatives as Tumor-Specific Cytotoxic Systems

Autor: Isabella Orienti, Guendalina Zuccari, R. Carosio, P. G. Montaldo

Publikováno v: Biomacromolecules. 6:2875-2880

A series of poly(vinyl alcohol) amphiphilic derivatives have been prepared to obtain polymeric aggregates in aqueous phase holding thermodynamic instability. The aim was to evaluate their ability to interact with tumor cells eliciting selective cytot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe64870b369a618fa37f432a7b6793a7
https://doi.org/10.1021/bm0504328

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Modified polyvinylalcohol for encapsulation of all-trans-retinoic acid in polymeric micelles

Autor: R. Carosio, Guendalina Zuccari, Adamo Fini, Paolo G. Montaldo, Isabella Orienti

Publikováno v: Journal of Controlled Release. 103:369-380

All-trans-retinoic acid (ATRA) is now included in many antitumor therapeutic schemes for the treatment of acute promyelocytic leukaemia, Kaposi's sarcoma, head and neck squamous cell carcinoma, ovarian carcinoma, bladder cancer and neuroblastoma. Unf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db381a0e2d986c941092dcaf9b5f182d
https://doi.org/10.1016/j.jconrel.2004.12.016

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