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Akademický článek

Harnessing noncanonical crRNAs to improve functionality of Cas12a orthologs

Autor: Long T. Nguyen, Nicolas C. Macaluso, Noah R. Rakestraw, Dylan R. Carman, Brianna L.M. Pizzano, Raymond C. Hautamaki, Santosh R. Rananaware, Isabel E. Roberts, Piyush K. Jain

Publikováno v: Cell Reports, Vol 43, Iss 2, Pp 113777- (2024)

Summary: There is a broad diversity among Cas12a endonucleases that possess nucleic acid detection and gene-editing capabilities, but few are studied extensively. Here, we present an exhaustive investigation of 23 Cas12a orthologs, with a focus on th

Externí odkaz: https://doaj.org/article/fa7c464d82e7437d8bba5ed5f812778d

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Akademický článek

Trace Amounts of Ranavirus Detected in Common Musk Turtles (Sternotherus odoratus) at a Site Where the Pathogen Was Previously Common

Autor: Rachel M. Goodman, Henry R. Carman, R. Paul Mahaffy, Nathan S. Cabrera

Publikováno v: Animals, Vol 13, Iss 18, p 2951 (2023)

Ranaviruses are global multi-host pathogens that infect ectothermic vertebrates and cause mass mortality events in some species. In 2021–2022, we surveyed two species of aquatic turtles in a Virginia site where previous research found ranavirus in

Externí odkaz: https://doaj.org/article/30b8294369444ce4a5767968e4033287

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Akademický článek

Species–specific crab predation on the hydrozoan clinging jellyfish Gonionemus sp. (Cnidaria, Hydrozoa), subsequent crab mortality, and possible ecological consequences

Autor: Mary R. Carman, David W. Grunden, Annette F. Govindarajan

Publikováno v: PeerJ, Vol 5, p e3966 (2017)

Here we report a unique trophic interaction between the cryptogenic and sometimes highly toxic hydrozoan clinging jellyfish Gonionemus sp. and the spider crab Libinia dubia. We assessed species–specific predation on the Gonionemus medusae by crabs

Externí odkaz: https://doaj.org/article/a38ff64c6dad436eb9270c1791f7192d

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Akademický článek

Mitochondrial diversity in Gonionemus (Trachylina:Hydrozoa) and its implications for understanding the origins of clinging jellyfish in the Northwest Atlantic Ocean

Autor: Annette F. Govindarajan, Mary R. Carman, Marat R. Khaidarov, Alexander Semenchenko, John P. Wares

Publikováno v: PeerJ, Vol 5, p e3205 (2017)

Determining whether a population is introduced or native to a region can be challenging due to inadequate taxonomy, the presence of cryptic lineages, and poor historical documentation. For taxa with resting stages that bloom episodically, determining

Externí odkaz: https://doaj.org/article/4f1394d3aaaf4b58b999db3c632c05eb

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Akademický článek

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Akademický článek

Accepting the Utopian Challenge: A Student Perspective

Autor: Brenna R. Carman

Publikováno v: InSight, Vol 8, Pp 80-84 (2013)

The scholarship of teaching and learning (SoTL) allows institutions to achieve the goals required for student learning and success. The purpose of this paper is to address recommendations for the implementation of SoTL that should have relevant input

Externí odkaz: https://doaj.org/article/353879c9c653416f9fd34ad5094fa984

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The Potential of Optometrists’ Referrals of Older Patients to Community-Based Exercise Programs: Findings From a Mixed-Methods Study

Autor: Carolyn R Carman, Rebecca L. Mauldin, Christina E. Miyawaki

Publikováno v: Journal of Aging and Physical Activity. 28:194-207

Exercise is important for older adults in order to prevent falls and live safer, healthier lives. Visual impairment is a risk factor for falling. Older adults tend to visit optometrists frequently; however, assessing patients’ physical exercise lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b7011f43ebcf2e6b855c5d6b2f129c
https://doi.org/10.1123/japa.2018-0442

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Engineering Highly Thermostable Cas12b via de novo Structural Analyses for One-Pot Detection of Nucleic Acids

Autor: Long T. Nguyen, Santosh R. Rananaware, Lilia G. Yang, Nicolas C. Macaluso, Julio E. Ocana-Ortiz, Katelyn S. Meister, Brianna L.M. Pizzano, Luke Samuel W. Sandoval, Raymond C. Hautamaki, Zoe R. Fang, Sara M. Joseph, Grace M. Shoemaker, Dylan R. Carman, Liwei Chang, Noah R. Rakestraw, Jon F. Zachary, Sebastian Guerra, Alberto Perez, Piyush K. Jain

Publikováno v: SSRN Electronic Journal.

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based diagnostics have elevated nucleic acid detection in terms of sensitivity, specificity, and rapidity in recent years. CRISPR-Cas systems can be combined with a pre-amplification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d950222abfcb268f2d9620980b48c6
https://doi.org/10.2139/ssrn.4309028

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Akademický článek

Dietary Carotenoids Regulate Astaxanthin Content of Copepods and Modulate Their Susceptibility to UV Light and Copper Toxicity

Autor: Kevin R. Carman, Soraya J. Silva, Maria-José Caramujo, Carla C. C. R. de Carvalho

Publikováno v: Marine Drugs, Vol 10, Iss 5, Pp 998-1018 (2012)

High irradiation and the presence of xenobiotics favor the formation of reactive oxygen species in marine environments. Organisms have developed antioxidant defenses, including the accumulation of carotenoids that must be obtained from the diet. Asta

Externí odkaz: https://doaj.org/article/60f8ceb7d9ac4b8daa1d62d5245ce022

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