Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

Autor: Vijendra K. Singh, Margaret E. Gnegy, S. P. Gupta, R. Leurs, R. C. Vollinga, H. Timmerman, Ray W. Fuller, Nissim Claude Cohen, Vincenzo Tschinke, Elaine J. Benaksas, E. David Murray, William J. Wechter, Indra Dwivedy, Suprabhat Ray

Volume 45 of'Progress in Drug Research'contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with neuro­ peptides as native immune modulators,

Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists

Autor: de Groote M, Visser S, van Muijlwijk-Koezen Je, Adriaan P. IJzerman, Frijtag von Drabbe Künzel J, R C Vollinga, Henk Timmerman

Publikováno v: van Muijlwijk-Koezen, J E, Timmerman, H, Vollinga, R C, Frijtag von Drabbe Kunzel, F, de Groote, M, Visser, S & AP., IJ 2001, ' Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists ', Journal of Medicinal Chemistry, vol. 44, pp. 749-762 . https://doi.org/10.1021/jm0003945
Journal of Medicinal Chemistry, 44, 749-762. American Chemical Society

Novel classes of heterocyclic compounds as adenosine antagonists were developed based on a template approach. Structure-affinity relationships revealed insights for extended knowledge of the receptor-ligand interaction. We replaced the bicyclic heter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded3174ba221a40d0913a49eb74277f2
https://doi.org/10.1021/jm0003945

N6,5‘-Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A3 Receptor

Autor: E. W. van Tilburg, Adriaan P. IJzerman, R C Vollinga, A. Lorenzen, J. K. Von Frijtag Drabbe Künzel, M de Groote

Publikováno v: Journal of Medicinal Chemistry. 42:1393-1400

5'-(Alkylthio)-substituted analogues of N6-benzyl- and N6-(3-iodobenzyl)adenosine were synthesized in 37-61% overall yields. The affinities of these compounds for the adenosine A1, A2A, and A3 receptors were determined using rat brain cortex, rat bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d58b8ff32d4f44c3871a5c76b4818b4
https://doi.org/10.1021/jm981090+

ChemInform Abstract: A New Convenient Route for the Synthesis of 4(5)-(ω-aminoalkyl)-1H-imidazoles

Autor: Wiro M. P. B. Menge, H. Timmerman, R. C. Vollinga

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b28bd0d0642dac2be02f715e9714938
https://doi.org/10.1002/chin.199333156

Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine

Autor: I J, De Esch, R C, Vollinga, K, Goubitz, H, Schenk, U, Appelberg, U, Hacksell, S, Lemstra, O P, Zuiderveld, M, Hoffmann, R, Leurs, W M, Menge, H, Timmerman

Publikováno v: Journal of medicinal chemistry. 42(7)

Various approaches to the synthesis of all four stereoisomers of 2-(1H-imidazol-4-yl)cyclopropylamine (cyclopropylhistamine) are described. The rapid and convenient synthesis and resolution of trans-cyclopropylhistamine is reported. The absolute conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b3fa4c60649c44db4d787bce2dca640
https://pubmed.ncbi.nlm.nih.gov/10197956