Zobrazeno 1 - 10
of 41
pro vyhledávání: '"R. C. Spike"'
Autor:
R. C. Spike, Paul D. Ross, Kenton T. Woodard, Sahana Nagabhushan Kalburgi, Mark E.S. Bailey, Stuart Cobb, Anne E. West, Kamal Ke Gadalla, R. Jude Samulski, Jie V. Deng, Steven J. Gray, Lavanya Bachaboina
Publikováno v:
Molecular Therapy. 21(1):18-30
Typical Rett syndrome (RTT) is a pediatric disorder caused by loss-of-function mutations in the methyl-CpG binding protein 2 (MECP2) gene. The demonstrated reversibility of RTT-like phenotypes in mice suggests that MECP2 gene replacement is a potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ffe00d1f7c3f206fd17eb6727dac52
Autor:
Kara McNair, Brian J. Morris, George C. Prendergast, Clare Guilding, Stuart Cobb, Trevor W. Stone, R. C. Spike
Publikováno v:
The Journal of Neuroscience. 30:3508-3517
Actin-rich dendritic spines are the locus of excitatory synaptic transmission and plastic events such as long-term potentiation (LTP). Morphological plasticity of spines accompanies activity-dependent changes in synaptic strength. Several Rho GTPase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb5fccc2643c17edd1a4a718dac2b0b
https://doi.org/10.1523/jneurosci.5386-09.2010
https://doi.org/10.1523/jneurosci.5386-09.2010
Publikováno v:
European Journal of Neuroscience. 18:2433-2448
In the rat lumbar spinal cord the major supraspinal targets for lamina I projection neurons are the caudal ventrolateral medulla (CVLM), lateral parabrachial area (LPb) and periaqueductal grey matter (PAG). In this study we have estimated the number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828113359a47a20bd09ac220ede49149
https://doi.org/10.1046/j.1460-9568.2003.02981.x
https://doi.org/10.1046/j.1460-9568.2003.02981.x
Publikováno v:
Brain Research. 964:218-227
In order to investigate whether cholera toxin B subunit (CTb) is transported by unmyelinated primary afferents following nerve injury, we transected the sciatic nerves of six rats, and injected the transected nerves (and in three cases also the intac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc98e59c0dc78bd75d5b2a78b00a7ab8
https://doi.org/10.1016/s0006-8993(02)04001-5
https://doi.org/10.1016/s0006-8993(02)04001-5
Publikováno v:
The Journal of Neuroscience. 22:4103-4113
Lamina I of the spinal cord is densely innervated by nociceptive primary afferents, many of which contain substance P. It contains numerous projection neurons: the majority of these respond to noxious stimuli, however some are activated by cooling. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0449c4b94413788d1a94d1e96324e99a
https://doi.org/10.1523/jneurosci.22-10-04103.2002
https://doi.org/10.1523/jneurosci.22-10-04103.2002
Publikováno v:
European Journal of Neuroscience. 15:1306-1316
A direct action of μ-opioid agonists on neurons in the spinal dorsal horn is thought to contribute to opiate-induced analgesia. In this study we have investigated neurons that express the μ-opioid receptor MOR-1 in rat spinal cord to provide furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c69fb1a398d5312fccbd7cd52caccecc
https://doi.org/10.1046/j.1460-9568.2002.01969.x
https://doi.org/10.1046/j.1460-9568.2002.01969.x
Publikováno v:
Neuroscience. 94:903-908
We have previously demonstrated that neurons in laminae III and IV of the spinal dorsal horn which possess the neurokinin-1 receptor and have long dorsal dendrites receive a major synaptic input from substance P-containing primary afferents and a mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6838ede044b1c4a6258e4943208f47
https://doi.org/10.1016/s0306-4522(99)00346-2
https://doi.org/10.1016/s0306-4522(99)00346-2
Publikováno v:
Neuroscience. 66:597-608
In order to provide further information about the types of spinal neuron which possess neurokinin-1 receptors, we have carried out pre-embedding immunocytochemistry on sections of rat lumbar spinal cord with an antiserum raised against a synthetic pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9256edf8a9bb8277d919062f9680fb00
https://doi.org/10.1016/0306-4522(95)00039-l
https://doi.org/10.1016/0306-4522(95)00039-l
Publikováno v:
European Journal of Neuroscience. 7:1-11
In order to examine the relationship between gephyrin (the peripheral membrane protein associated with glycine receptors) and glycinergic boutons, we have carried out a post-embedding immunogold study of glycine-like immunoreactivity on sections of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d7518c40cbaa7a3bb8923bd317cf78
https://doi.org/10.1111/j.1460-9568.1995.tb01014.x
https://doi.org/10.1111/j.1460-9568.1995.tb01014.x
Autor:
Adrian Bird, Gernot Riedel, Emma Brockett, Jim Selfridge, Cara Merusi, Leanne C. McKay, R. C. Spike, Jacky Guy, Dina De Sousa, Lianne Robinson, Stuart Cobb
Rett syndrome is a neurological disorder caused by mutation of the X-linked MECP2 gene. Mice lacking functional Mecp2 display a spectrum of Rett syndrome-like signs, including disturbances in motor function and abnormal patterns of breathing, accompa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6526101e07fd957bbf45a73fac37bdad
https://europepmc.org/articles/PMC3437019/
https://europepmc.org/articles/PMC3437019/
