Výsledky vyhledávání - "R. C. Raatgeep"

Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis

Autor: Marianna Parlato, Sandrine Nugteren, D.J. Lindenbergh-Kortleve, Remy Boisgard, R. C. Raatgeep, Nicolas Guegan, Iris H I M Hollink, Nadine Cerf-Bensussan, L M M Costes, Fabienne Charbit-Henrion, M. Luisa Mearin, Johanna C. Escher, Valérie Malan, Jan Krzysztof Nowak, Janneke N. Samsom, Sharon Veenbergen, Maria E. Joosse

Publikováno v: Mucosal Immunology, 14(5), 1172-1182. SPRINGERNATURE
Mucosal Immunology
Mucosal Immunology, 14(5), 1172-1182. Nature Publishing Group

Single genetic mutations predispose to very early onset inflammatory bowel disease (VEO-IBD). Here, we identify a de novo duplication of the 10p15.1 chromosomal region, including the IL2RA locus, in a 2-year-old girl with treatment-resistant pancolit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a002db7d270b9a537d87accc4d0b3ea0
https://hdl.handle.net/1887/3277458

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DOP09 IgG responses to multiple bacterial flagellins identify a subgroup of paediatric therapy-naive Crohn’s disease patients with increased microbiota-specific T-cell reactivity

Autor: Katie L. Alexander, L M M Costes, L. de Ridder, Maria M E Jongsma, Maria E. Joosse, R. C. Raatgeep, A P Heikema, Charles O. Elson, Johanna C. Escher, D H van Haaften, M Aardoom, Irma Tindemans, Frank M. Ruemmele, Polychronis Kemos, Janneke N. Samsom, Nicholas M. Croft, L.W. Duck

Publikováno v: Journal of Crohn's and Colitis. 14:S046-S046

Background inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic intestinal disease driven by inflammatory T-cell responses thought to target intestinal bacteria. However, evidence for such micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c34d6fceebb5cd9d9e45456fc878fe35
https://doi.org/10.1093/ecco-jcc/jjz203.048

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IL-10 signaling prevents gluten-dependent intraepithelial CD4

Autor: L M M, Costes, D J, Lindenbergh-Kortleve, L A, van Berkel, S, Veenbergen, H R C, Raatgeep, Y, Simons-Oosterhuis, D H, van Haaften, J J, Karrich, J C, Escher, M, Groeneweg, B E, Clausen, T, Cupedo, J N, Samsom

Publikováno v: Mucosal immunology. 12(2)

Breach of tolerance to gluten leads to the chronic small intestinal enteropathy celiac disease. A key event in celiac disease development is gluten-dependent infiltration of activated cytotoxic intraepithelial lymphocytes (IELs), which cytolyze epith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b07708455241d434e4f1afeb0b58468
https://pubmed.ncbi.nlm.nih.gov/30542112

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Hydrogen peroxide in breath condensate during a common cold

Autor: Susanne L. Schellekens, Anoeska Fakkel-Kroesbergen, Johan C. de Jongste, Rijn Q. Jöbsis, R. C. Raatgeep

Publikováno v: Mediators of Inflammation, 10, 351-354. Hindawi Publishing Corporation
Mediators of Inflammation
Mediators of Inflammation, 10(6), 351-354. Hindawi Publishing Corporation
Mediators of Inflammation, Vol 10, Iss 6, Pp 351-354 (2001)

Background:Hydrogen peroxide (H2O2) in exhaled air condensate is elevated in inflammatory disorders of the lower respiratory tract. It is unknown whether viral colds contribute to exhaled H2O2.Aim:To assess exhaled H2O2during and after a common cold.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279353cc8065005ad5980bf8da794766
https://hdl.handle.net/1765/31841

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Effect of hyperosmolarity on human isolated central airways

Autor: Theo Stijnen, R. C. Raatgeep, R. C. Jongejan, J. C. De Jongste, Ivan L. Bonta, K. F. Kerrebijn

Publikováno v: British Journal of Pharmacology. 102:931-937

1. We studied the effect of hyperosmolarity on human isolated airways because a better understanding of the effect of hyperosmolarity on the human airway wall may improve insight into the pathophysiology of hyperosmolarity-induced bronchoconstriction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d820cecfc0ea317867c88b34807ebda1
https://doi.org/10.1111/j.1476-5381.1991.tb12279.x

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Effects of Zymosan-activated Human Granulocytes on Isolated Human Airways

Autor: I. L. Bonta, J. C. De Jongste, R. C. Raatgeep, R. C. Jongejan, K. F. Kerrebijn

Publikováno v: American Review of Respiratory Disease. 143:553-560

In asthma a temporal association exists between the late allergic reaction (LAR), the influx of granulocytes into the airway wall, and an increase in bronchial responsiveness. We therefore tested the hypothesis that activated human granulocytes const

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196966b4d63011eabd64e1a546c57e7e
https://doi.org/10.1164/ajrccm/143.3.553

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Effect of Cooling on Responses of Isolated Human Airways to Pharmacologic and Electrical Stimulation

Autor: Johan C. de Jongste, Roberto C. Jongejan, K.F. Kerrebijn, R. C. Raatgeep, Ivan L. Bonta

Publikováno v: American Review of Respiratory Disease. 143:369-374

We studied the effect of cooling on the responses of isolated human airways to the beta-agonist isoproterenol, the alpha/beta-agonist norepinephrine in the presence of the beta-blocker timolol, methacholine, leukotriene C4 (LTC4), and histamine. In a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab36a72415f7ff4f2fafaec1d0f21c1
https://doi.org/10.1164/ajrccm/143.2.369

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Effects of Inflammatory Mediators on the Responsiveness of Isolated Human Airways to Methacholine

Autor: I. L. Bonta, J. C. De Jongste, Theo Stijnen, R. C. Jongejan, R. C. Raatgeep, K. F. Kerrebijn

Publikováno v: American Review of Respiratory Disease. 142:1129-1132

Several studies have suggested that in asthmatics the quantities of inflammatory mediators such as histamine, thromboxane A2 (TxA2), prostaglandin D2 (PGD2), prostaglandin F2 alpha (PGF2 alpha), and leukotriene C4 (LTC4) that are present in the airwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542577ccdb30912230982baf4af45699
https://doi.org/10.1164/ajrccm/142.5.1129

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Effects of changes in osmolarity on isolated human airways

Autor: R. C. Raatgeep, I. L. Bonta, R. C. Jongejan, K. F. Kerrebijn, J. C. de Jongste

Publikováno v: Journal of Applied Physiology. 68:1568-1575

The effects of hypo- and hyperosmolarity on the function of isolated human airways were studied. Changes in osmolarity induced an increasing bronchoconstriction that was proportional to the magnitude of the change in osmolarity. Hypertonicity-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e06577d420af7ef2c57c67be9bdc86
https://doi.org/10.1152/jappl.1990.68.4.1568

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