Zobrazeno 1 - 10
of 30
pro vyhledávání: '"R. C. Fitzgerald"'
Autor:
A. C. Katz-Summercorn, S. Jammula, A. Frangou, I. Peneva, M. O’Donovan, M. Tripathi, S. Malhotra, M. di Pietro, S. Abbas, G. Devonshire, W. Januszewicz, A. Blasko, K. Nowicki-Osuch, S. MacRae, A. Northrop, A. M. Redmond, D. C. Wedge, R. C. Fitzgerald
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The alterations associated with progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma are not fully characterised. Here, the authors perform a multi-omics analysis of a longitudinally-sampled BE patient cohort, identifying the impa
Externí odkaz:
https://doaj.org/article/f6679ac4c012459a94f788f21c46d6ba
Autor:
E. Madissoon, A. Wilbrey-Clark, R. J. Miragaia, K. Saeb-Parsy, K. T. Mahbubani, N. Georgakopoulos, P. Harding, K. Polanski, N. Huang, K. Nowicki-Osuch, R. C. Fitzgerald, K. W. Loudon, J. R. Ferdinand, M. R. Clatworthy, A. Tsingene, S. van Dongen, M. Dabrowska, M. Patel, M. J. T. Stubbington, S. A. Teichmann, O. Stegle, K. B. Meyer
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-16 (2019)
Abstract Background The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an atlas. However, delays between fresh
Externí odkaz:
https://doaj.org/article/3e59212c239c4ce79059bf72833722a9
Autor:
A C, Katz-Summercorn, S, Jammula, A, Frangou, I, Peneva, M, O'Donovan, M, Tripathi, S, Malhotra, M, di Pietro, S, Abbas, G, Devonshire, W, Januszewicz, A, Blasko, K, Nowicki-Osuch, S, MacRae, A, Northrop, A M, Redmond, D C, Wedge, R C, Fitzgerald
Publikováno v:
Nature communications. 13(1)
Barrett's esophagus is a pre-malignant lesion that can progress to esophageal adenocarcinoma. We perform a multi-omic analysis of pre-cancer samples from 146 patients with a range of outcomes, comprising 642 person years of follow-up. Whole genome se
Autor:
S A Rahman, R C Walker, M A Lloyd, B L Grace, G I van Boxel, B F Kingma, J P Ruurda, R van Hillegersberg, S Harris, S Parsons, S Mercer, E A Griffiths, J R O'Neill, R Turkington, R C Fitzgerald, T J Underwood, Ayesha Noorani, Rachael Fels Elliott, Paul A W Edwards, Nicola Grehan, Barbara Nutzinger, Jason Crawte, Hamza Chettouh, Gianmarco Contino, Xiaodun Li, Eleanor Gregson, Sebastian Zeki, Rachel de la Rue, Shalini Malhotra, Simon Tavaré, Andy G Lynch, Mike L Smith, Jim Davies, Charles Crichton, Nick Carroll, Peter Safranek, Andrew Hindmarsh, Vijayendran Sujendran, Stephen J Hayes, Yeng Ang, Shaun R Preston, Sarah Oakes, Izhar Bagwan, Vicki Save, Richard J E Skipworth, Ted R Hupp, J Robert O'Neill, Olga Tucker, Andrew Beggs, Philippe Taniere, Sonia Puig, Timothy J Underwood, Fergus Noble, James P Byrne, Jamie J Kelly, Jack Owsley, Hugh Barr, Neil Shepherd, Oliver Old, Jesper Lagergren, James Gossage, Andrew Davies Fuju Chang, Janine Zylstra, Vicky Goh, Francesca D Ciccarelli, Grant Sanders, Richard Berrisford, Catherine Harden, David Bunting, Mike Lewis, Ed Cheong, Bhaskar Kumar, Simon L Parsons, Irshad Soomro, Philip Kaye, John Saunders, Laurence Lovat, Rehan Haidry, Victor Eneh, Laszlo Igali, Michael Scott, Shamila Sothi, Sari Suortamo, Suzy Lishman, George B Hanna, Christopher J Peters, Anna Grabowska
Publikováno v:
on behalf of the OCCAMS Consortium, Rahman, S A, Walker, R C, Lloyd, M A, Grace, B L, van Boxel, G I, Kingma, B F, Ruurda, J P, van Hillegersberg, R, Harris, S, Parsons, S, Mercer, S, Griffiths, E A, O'Neill, J R, Turkington, R, Fitzgerald, R C & Underwood, T J 2020, ' Machine learning to predict early recurrence after oesophageal cancer surgery ', British Journal of Surgery, vol. 107, no. 8, pp. 1042-1052 . https://doi.org/10.1002/bjs.11461
The British Journal of Surgery
The British Journal of Surgery
Background Early cancer recurrence after oesophagectomy is a common problem, with an incidence of 20–30 per cent despite the widespread use of neoadjuvant treatment. Quantification of this risk is difficult and existing models perform poorly. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baa9c5e8d31ed77fb83c07c2aab1614
Publikováno v:
British Journal of Surgery. 96:724-733
Background Oesophageal adenocarcinoma is the commonest oesophageal malignancy in the West, but is staged using a system designed for squamous cell carcinoma. The aim was to develop and validate a staging system for oesophageal and junctional adenocar
Autor:
D F, Boerwinkel, M, Di Pietro, X, Liu, M K, Shariff, P, Lao-Sirieix, C E, Walker, M, Visser, M, O' Donovan, P, Kaye, J J G H M, Bergman, R C, Fitzgerald
Publikováno v:
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 27(5)
In Barrett's esophagus (BE), the normal squamous lining of the esophagus is replaced by specialized columnar epithelium. Endoscopic surveillance with autofluorescence imaging (AFI) and molecular biomarkers have been studied separately to detect early
Autor:
C J, Peters, R C, Fitzgerald
Publikováno v:
Alimentary pharmacologytherapeutics. 25(11)
Oesophageal adenocarcinoma is an increasingly common cancer with a poor prognosis. It develops in a stepwise progression from Barrett's metaplasia to dysplasia, and then adenocarcinoma followed by metastasis.To outline the key molecular changes in oe
Publikováno v:
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 19(1)
We compared whole genomic changes in cell lines generated from esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). To do so, we investigated chromosomal DNA copy number changes in four EAC cell lines and three ESCC cell lin
Autor:
R C, Fitzgerald
Publikováno v:
Alimentary pharmacologytherapeutics. 20
In the UK and across the Western world there has been a rapid increase in oesophageal adenocarcinoma, such that this cancer is now more common than squamous cell carcinoma. The 5-year mortality from oesophageal adenocarcinoma is80% and therefore ther
Publikováno v:
Digestive diseases and sciences. 46(9)
Esophageal adenocarcinoma is increasing in incidence and has a high mortality unless detected early. Barrett's esophagus is the only known risk factor for this cancer; however, whether endoscopic surveillance reduces morbidity and mortality is contro