Zobrazeno 1 - 10
of 208
pro vyhledávání: '"R. Brunham"'
Genetic Testing for Familial Hypercholesterolemia: The Current State of Its Implementation in Canada
Autor:
Adam I. Kramer, MD, MSc, Susan Christian, MSc, PhD, Kirsten Bartels, MSc, Nicol Vaizman, BS, Robert A. Hegele, MD, Liam R. Brunham, MD, PhD
Publikováno v:
CJC Open, Vol 6, Iss 11, Pp 1395-1402 (2024)
Background: Familial hypercholesterolemia (FH) is a common genetic disorder, yet it remains largely underdiagnosed in Canada. Multiple national and international guidelines recommend the use of clinical genetic testing for FH. However, the level of i
Externí odkaz:
https://doaj.org/article/f49f497e8c9a4d53994a602c3b7ba285
Autor:
Diana N. Vikulova, Danielle Pinheiro-Muller, Gordon Francis, Frank Halperin, Tara Sedlak, Keith Walley, Christopher Fordyce, GB John Mancini, Simon N. Pimstone, Liam R. Brunham
Publikováno v:
American Journal of Preventive Cardiology, Vol 19, Iss , Pp 100704- (2024)
Background: Screening first-degree relatives (FDRs) of patients with premature coronary artery disease (CAD) is recommended but not routinely performed. Objectives: To assess the diagnostic yield and impact on clinical management of a clinical and im
Externí odkaz:
https://doaj.org/article/da10569a35ea41f39373ea03d9874d70
Autor:
Emilie T. Théberge, MSc, Diana N. Vikulova, MD, Simon N. Pimstone, MD, PhD, Liam R. Brunham, MD, PhD, Karin H. Humphries, DSc, Tara L. Sedlak, MD, MBA
Publikováno v:
CJC Open, Vol 6, Iss 2, Pp 279-291 (2024)
Background: Heart disease is the leading cause of premature death for women in Canada. Ischemic heart disease is categorized as myocardial infarction (MI) with no obstructive coronary artery disease (MINOCA), ischemia with no obstructive coronary art
Externí odkaz:
https://doaj.org/article/4a6ef8fda3934fdc81b093a2492c9d19
Autor:
C. A. D’Souza, J. W. Kronstad, G. Taylor, R. Warren, M. Yuen, G. Hu, W. H. Jung, A. Sham, S. E. Kidd, K. Tangen, N. Lee, T. Zeilmaker, J. Sawkins, G. McVicker, S. Shah, S. Gnerre, A. Griggs, Q. Zeng, K. Bartlett, W. Li, X. Wang, J. Heitman, J. E. Stajich, J. A. Fraser, W. Meyer, D. Carter, J. Schein, M. Krzywinski, K. J. Kwon-Chung, A. Varma, J. Wang, R. Brunham, M. Fyfe, B. F. F. Ouellette, A. Siddiqui, M. Marra, S. Jones, R. Holt, B. W. Birren, J. E. Galagan, C. A. Cuomo
Publikováno v:
mBio, Vol 2, Iss 1 (2011)
ABSTRACT Cryptococcus gattii recently emerged as the causative agent of cryptococcosis in healthy individuals in western North America, despite previous characterization of the fungus as a pathogen in tropical or subtropical regions. As a foundation
Externí odkaz:
https://doaj.org/article/bb93a593590e4e4e833b8232b95e9efd
Autor:
Natalia Ryzhaya, Lubomira Cermakova, Mark Trinder, Isabelle Ruel, Thais Coutinho, Jacques Genest, Liam R. Brunham
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/62066b5c78f34cda93554aeec1159233
Autor:
Raymond Y. Cho, BSc, Jian Weng, BSc, Kelsey Lynch, MSc, CGC, Phoebe Ng, BSc, Chad Brown, BSc, Alison M. Hoens, MSc, BScPT, Kevin Barry, Liam R. Brunham, MD, PhD, FRCPC, Simon Pimstone, MD, PhD, FRCPC
Publikováno v:
CJC Open, Vol 1, Iss 3, Pp 107-114 (2019)
Background: Optimal design of clinical programs for patients with premature atherosclerotic cardiovascular disease (ASCVD) (men aged ≤ 50 years, women aged ≤ 55 years) requires an understanding of their priorities. We aimed to explore patient and
Externí odkaz:
https://doaj.org/article/c5f4dd2edf17455db0ca38bea49d0bf8
Autor:
Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai, Boon-Cher Goh
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-10 (2018)
Abstract Background Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. Methods An open-label, non-inf
Externí odkaz:
https://doaj.org/article/087728fcda5943cda118924e863a9094
Autor:
Diana N. Vikulova, Maja Grubisic, Yinshan Zhao, Kelsey Lynch, Karin H. Humphries, Simon N. Pimstone, Liam R. Brunham
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 14 (2019)
Background The incidence of atherosclerotic cardiovascular disease has declined in the past 2 decades. However, these benefits may not extend to young patients. The objective of this work was to assess temporal trends in the incidence, risk profiles,
Externí odkaz:
https://doaj.org/article/b594bd92dc304fb4b1999ddbdd51e69c
Autor:
Emilie T. Théberge, Diana N. Vikulova, Simon N. Pimstone, Liam R. Brunham, Karin H. Humphries, Tara L. Sedlak
BackgroundHeart disease is the leading cause of premature death for women in Canada. Ischemic heart disease (IHD) is categorized as myocardial infarction (MI) with no obstructive coronary artery disease (MINOCA), ischemia with no obstructive coronary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4615afb92bc71dba14ad33037afee5af
https://doi.org/10.1101/2023.05.13.23289927
https://doi.org/10.1101/2023.05.13.23289927
Autor:
Ahsen Chaudhry, Mark Trinder, Kristin Vesely, Lubomira Cermakova, Linda Jackson, Jian Wang, Robert A. Hegele, Liam R. Brunham
Publikováno v:
Circulation: Genomic and Precision Medicine. 16
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by extremely elevated plasma low-density lipoprotein cholesterol and accelerated atherosclerosis. Accurate identification of patients with HoFH is es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::139a9e8d5b14f830907c226dc87f4d2d
https://doi.org/10.1161/circgen.122.003887
https://doi.org/10.1161/circgen.122.003887