Zobrazeno 1 - 10
of 348
pro vyhledávání: '"R. Brightwell"'
Autor:
Andrea L. Dimet-Wiley, Christine M. Latham, Camille R. Brightwell, Harshini Neelakantan, Alexander R. Keeble, Nicholas T. Thomas, Haley Noehren, Christopher S. Fry, Stanley J. Watowich
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising
Externí odkaz:
https://doaj.org/article/bd2c80f1e7bf42fd9e877971c7a909b7
Autor:
Camille R. Brightwell, Ameya S. Kulkarni, William Paredes, Kehao Zhang, Jaclyn B. Perkins, Knubian J. Gatlin, Matthew Custodio, Hina Farooq, Bushra Zaidi, Rima Pai, Rupinder S. Buttar, Yan Tang, Michal L. Melamed, Thomas H. Hostetter, Jeffrey E. Pessin, Meredith Hawkins, Christopher S. Fry, Matthew K. Abramowitz
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
BACKGROUND Skeletal muscle maladaptation accompanies chronic kidney disease (CKD) and negatively affects physical function. Emphasis in CKD has historically been placed on muscle fiber–intrinsic deficits, such as altered protein metabolism and atro
Externí odkaz:
https://doaj.org/article/28e2b2ab95fc4aababe1574c610d359a
Autor:
Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evi
Externí odkaz:
https://doaj.org/article/0bc07f083e994c3a999d215e49a6bcfe
Autor:
Kevin A. Murach, Bailey D. Peck, Robert A. Policastro, Ivan J. Vechetti, Douglas W. Van Pelt, Cory M. Dungan, Lance T. Denes, Xu Fu, Camille R. Brightwell, Gabriel E. Zentner, Esther E. Dupont-Versteegden, Christopher I. Richards, Jeramiah J. Smith, Christopher S. Fry, John J. McCarthy, Charlotte A. Peterson
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102372- (2021)
Summary: Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking, satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show satellite cells communicate with other cells in skeletal m
Externí odkaz:
https://doaj.org/article/bf5d536bcc1c44ae96a88fbbda14f370
Autor:
Ronald G. Jones, Andrea Dimet‐Wiley, Amin Haghani, Francielly Morena da Silva, Camille R. Brightwell, Seongkyun Lim, Sabin Khadgi, Yuan Wen, Cory M. Dungan, Robert T. Brooke, Nicholas P. Greene, Charlotte A. Peterson, John J. McCarthy, Steve Horvath, Stanley J. Watowich, Christopher S. Fry, Kevin A. Murach
Publikováno v:
The Journal of Physiology. 601:763-782
Advances in the last decade related to cellular epigenetic reprogramming (e.g. DNA methylome remodeling) toward a pluripotent state via the Yamanaka transcription factors Oct3/4, Klf4, Sox2, and Myc (OKSM) provide a window into potential mechanisms f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d8192b7fe90ddf4aceec3140e5b7e7
https://doi.org/10.1113/jp283836
https://doi.org/10.1113/jp283836
Autor:
Alexander R. Keeble, Camille R. Brightwell, Christine M. Latham, Nicholas T. Thomas, C. Brooks Mobley, Kevin A. Murach, Darren L. Johnson, Brian Noehren, Christopher S. Fry
Publikováno v:
The American Journal of Sports Medicine. 51:81-96
Background: Anterior cruciate ligament (ACL) tear (ACLT) leads to protracted quadriceps muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to injury and loading. Regulation of quadriceps molecular protein synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f299071197d6e43dd593fabea67be4e
https://doi.org/10.1177/03635465221135769
https://doi.org/10.1177/03635465221135769
Autor:
Camille R. Brightwell, Christine M. Latham, Nicholas T. Thomas, Alexander R. Keeble, Kevin A. Murach, Christopher S. Fry
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of mononuclear cell types that reside in the extracellular matrix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f5a78c54f52368a0f9f5505f56b919
https://pubmed.ncbi.nlm.nih.gov/35876284
https://pubmed.ncbi.nlm.nih.gov/35876284
Autor:
Cory M, Dungan, Vandre C, Figueiredo, Yuan, Wen, Georgia L, VonLehmden, Christopher J, Zdunek, Nicholas T, Thomas, C Brooks, Mobley, Kevin A, Murach, Camille R, Brightwell, Douglas E, Long, Christopher S, Fry, Philip A, Kern, John J, McCarthy, Charlotte A, Peterson
Publikováno v:
GeroScience. 44:1925-1940
With aging, skeletal muscle plasticity is attenuated in response to exercise. Here, we report that senescent cells, identified using senescence-associated β-galactosidase (SA β-Gal) activity and p21 immunohistochemistry, are very infrequent in rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0321ef5442829d9ee23a5a40001454be
https://doi.org/10.1007/s11357-022-00542-2
https://doi.org/10.1007/s11357-022-00542-2
Autor:
Jean L. Fry, Christopher S. Fry, Anders H. Andersen, Peter A. Hardy, Camille R. Brightwell, Katherine L. Thompson, Moriel H. Vandsburger, Brian Noehren
Publikováno v:
J Physiol
Dysregulation and fibrotic transformation of the skeletal muscle extracellular matrix (ECM) is a common pathology associated with injury and aging Studies of the muscle ECM in humans have necessitated the use of biopsies, which are impractical in man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c304ede6d571ba10348ec6ecef77e12c
https://doi.org/10.1113/jp281964
https://doi.org/10.1113/jp281964
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