Human podocytes perform polarized, caveolae-dependent albumin endocytosis

Autor: Evgenia Dobrinskikh, R. Brian Doctor, Kayo Okamura, Jeffrey B. Kopp, Judith Blaine

Publikováno v: American Journal of Physiology-Renal Physiology. 306:F941-F951

The renal glomerulus forms a selective filtration barrier that allows the passage of water, ions, and small solutes into the urinary space while restricting the passage of cells and macromolecules. The three layers of the glomerular filtration barrie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361fb6c6f5d150dc04f86b3de832aa6c
https://doi.org/10.1152/ajprenal.00532.2013

Distinct patterns of kidney and liver cyst growth in pkd2(WS25/−) mice

Autor: Charles L. Edelstein, Kendra M. Hasebroock, Natalie J. Serkova, Iram Zafar, R. Brian Doctor

Publikováno v: Nephrology Dialysis Transplantation. 25:3496-3504

Background. Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease that results in the development of cystic kidneys and liver. Pkd2(WS25/−) mice are a key genetic mouse model of human ADPKD that recapitulate the ‘molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f678eff00dc1556e3a36bb6ab4433193
https://doi.org/10.1093/ndt/gfq195

CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation

Autor: Kim McFann, Berenice Gitomer, Robert W. Schrier, Claudia R. Amura, Gwendal Lazennec, Kelley S. Brodsky, R. Brian Doctor, Matthew T. Nichols, Alkesh Jani

Publikováno v: American Journal of Physiology-Cell Physiology
American Journal of Physiology-Cell Physiology, American Physiological Society, 2008, 294 (3), pp.C786-96. ⟨10.1152/ajpcell.00457.2007⟩

International audience; Autosomal dominant polycystic kidney disease (ADPKD) is a highly prevalent genetic disease that results in cyst formation in kidney and liver. Cytokines and growth factors secreted by the cyst-lining epithelia are positioned t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83476b9a780d6ca1bf03e30792157658
https://doi.org/10.1152/ajpcell.00457.2007

Polycystic liver: clinical characteristics of patients with isolated polycystic liver disease compared with patients with polycystic liver and autosomal dominant polycystic kidney disease

Autor: Inge A. Hoevenaren, R. Brian Doctor, Joost P.H. Drenth, Ruth Wester, Kim McFann, Gregory T. Everson, Robert W. Schrier

Publikováno v: Liver International. 28:264-270

AIM: The goal of this study was to compare the clinical features of patients with isolated polycystic liver disease (PCLD) with those of patients with polycystic liver and autosomal dominant polycystic kidney disease (ADPKD). METHODS: Cases were iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5afc17bc44394c6869af8563143ad27b
https://doi.org/10.1111/j.1478-3231.2007.01595.x

Increased susceptibility of fat-laden Zucker-rat hepatocytes to bile acid-induced oncotic necrosis: An in vitro model of steatocholestasis

Autor: Maret G. Traber, Rolf Dahl, Michael W. Devereaux, R. Brian Doctor, Eric Gumpricht, Gregory E. Kobak, Ronald J. Sokol

Publikováno v: Journal of Laboratory and Clinical Medicine. 145:247-262

Metabolic liver disorders cause chronic liver disease and liver failure in childhood. Many of these disorders share the histologic features of steatosis and cholestasis, or steatocholestasis. In this study we sought to (1) develop an in vitro model o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bd61ca999e56a668393b6bccfed338
https://doi.org/10.1016/j.lab.2004.12.007