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Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout

Autor: T Kanaitsuka, R Bortell, L A Stevens, J Moss, D Sardinha, T V Rajan, D Zipris, J P Mordes, D L Greiner, A A Rossini

Publikováno v: The Journal of Immunology. 159:2741-2749

Several proteins with NAD+:arginine ADP-ribosyltransferase (ART) activity are expressed in T cells and affect their function. Rat T cells that express the ART designated RT6 are determinants of the expression of autoimmune diabetes. In the mouse, a 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f685bfda0bf55d14662b391e7bf8e739
https://doi.org/10.4049/jimmunol.159.6.2741

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Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity

Autor: M R Rigby, R Bortell, L A Stevens, J Moss, T Kanaitsuka, H Shigeta, J P Mordes, D L Greiner, A A Rossini

Publikováno v: The Journal of Immunology. 156:4259-4265

RT6 is a glycosylphosphatidylinositol-linked protein found on the surface of mature rat T lymphocytes. Cells that express RT6 have an immunoregulatory function and modulate the expression of autoimmune diabetes mellitus in the BioBreeding rat. A homo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8186da3c6de1802cccf5b9c01ad855e2
https://doi.org/10.4049/jimmunol.156.11.4259

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Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression

Autor: H F DeLuca, Ellen C. Breen, R Bortell, Joseph P. Bidwell, J L Stein, J B Lian, A. J. Van Wijnen, Paola Gavazzo, T A Owen, Gary S. Stein

Publikováno v: Proceedings of the National Academy of Sciences. 89:6119-6123

The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba2f944ed3ceaea81c4aeeb0acc0c3f
https://doi.org/10.1073/pnas.89.13.6119

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The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse

Autor: R, Bortell, T, Kanaitsuka, L A, Stevens, J, Moss, J P, Mordes, A A, Rossini, D L, Greiner

Publikováno v: Molecular and cellular biochemistry. 193(1-2)

Recent evidence suggests that a new member of the mono-ADP-ribosyltransferase/NAD glycohydrolase family, RT6, may be important in immune regulation. RT6 is expressed in two allelic forms and is present on post-thymic T cells in the rat. RT6-expressin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64fff47ced105fc0f4d66f7f413d4f4e
https://pubmed.ncbi.nlm.nih.gov/10331639

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Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation: glucocorticoid regulation of basal and vitamin D stimulated gene expression

Autor: V, Shalhoub, F, Aslam, E, Breen, A, van Wijnen, R, Bortell, G S, Stein, J L, Stein, J B, Lian

Publikováno v: Journal of cellular biochemistry. 69(2)

We have examined the contribution of transcriptional mechanisms to the pleiotropic effects of glucocorticoids on basal and vitamin D stimulated expression of the developmentally regulated bone-specific osteocalcin (OC) gene. OC expression was systema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65cafee6c56254ad8e8fdcc1402222ae
https://pubmed.ncbi.nlm.nih.gov/9548563

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Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity

Autor: R, Bortell, M, Rigby, L, Stevens, J, Moss, T, Kanaitsuka, J, Mordes, D, Greiner, A, Rossini

Publikováno v: Advances in experimental medicine and biology. 419

We report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP-ribosyltransferase activity and that Rt6, but not RT6, catalyzes the ADP-ribosylation of exogenous histones. Based on NH2OH sensitivity, it appeared that the ADP-rib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6e01e86b91bcb233fb0584b699d3d64
https://pubmed.ncbi.nlm.nih.gov/9193650

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Concerted control of multiple histone promoter factors during cell density inhibition of proliferation in osteosarcoma cells: reciprocal regulation of cell cycle-controlled and bone-related genes

Autor: F M, van den Ent, A J, van Wijnen, T J, Last, R, Bortell, J L, Stein, J B, Lian, G S, Stein

Publikováno v: Cancer research. 53

Cell density-induced growth inhibition of osteosarcoma cells (ROS 17/2.8) results in the shutdown of proliferation-specific histone H4 and H2B genes and the concomitant up-regulation of several osteoblast-related genes. In several respects, this reci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e18db02732b162de101372b64625a2d0
https://pubmed.ncbi.nlm.nih.gov/8485727

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