Zobrazeno 1 - 10
of 659
pro vyhledávání: '"R. Beier"'
Autor:
Daryl M. Okamura, Chris M. Brewer, Paul Wakenight, Nadia Bahrami, Kristina Bernardi, Amy Tran, Jill Olson, Xiaogang Shi, Szu-Ying Yeh, Adrian Piliponsky, Sarah J. Collins, Elizabeth D. Nguyen, Andrew E. Timms, James W. MacDonald, Theo K. Bammler, Branden R. Nelson, Kathleen J. Millen, David R. Beier, Mark W. Majesky
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103269- (2021)
Summary: Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. Whether spiny mice also regenerate internal orga
Externí odkaz:
https://doaj.org/article/14339f301a224e7fbcad8ed0416f3953
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 2, Pp 401-409 (2018)
Positional cloning of ENU-induced mutations has traditionally relied on analysis of polymorphic variation between two strains. In contrast, the application of whole-genome sequencing (WGS) has enabled gene discovery in mutant lines maintained on an i
Externí odkaz:
https://doaj.org/article/a3b72831dd454ce8b7b0edc84f8b4d2f
Autor:
Alexander Strassman, Frank Schnütgen, Qi Dai, Jennifer C. Jones, Angela C. Gomez, Lenore Pitstick, Nathan E. Holton, Russell Moskal, Erin R. Leslie, Harald von Melchner, David R. Beier, Bryan C. Bjork
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 7, Pp 909-922 (2017)
Gene trap mutagenesis is a powerful tool to create loss-of-function mutations in mice and other model organisms. Modifications of traditional gene trap cassettes, including addition of conditional features in the form of Flip-excision (FlEx) arrays t
Externí odkaz:
https://doaj.org/article/6b4e3b20140d48539758e197974877ee
Autor:
Elizabeth Bittermann, Zakia Abdelhamed, Ryan P Liegel, Chelsea Menke, Andrew Timms, David R Beier, Rolf W Stottmann
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008243 (2019)
Tubulin genes encode a series of homologous proteins used to construct microtubules which are essential for multiple cellular processes. Neural development is particularly reliant on functional microtubule structures. Tubulin genes comprise a large f
Externí odkaz:
https://doaj.org/article/9d52733258a44ba8acb68446ac9f11f2
Autor:
Krista A. Geister, Alberto Jose Lopez-Jimenez, Scott Houghtaling, Tzu-Hua Ho, Roberto Vanacore, David R. Beier
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 6 (2019)
In a screen for organogenesis defects in N-ethyl-N-nitrosourea (ENU)-induced mutant mice, we discovered a line carrying a mutation in Colgalt1 [collagen beta(1-O)galactosyltransferase type 1], which is required for proper galactosylation of hydroxyly
Externí odkaz:
https://doaj.org/article/2e4d09eb836c4822bbc833719b711875
Autor:
Elizabeth Dong Nguyen, Vahid Nikoonejad Fard, Bernard Y. Kim, Sarah Collins, Miranda Galey, Branden R. Nelson, Paul Wakenight, Simone M. Gable, Aaron McKenna, Theo K. Bammler, Jim MacDonald, Daryl M. Okamura, Jay Shendure, David R. Beier, Jan Marino Ramirez, Mark W. Majesky, Kathleen J. Millen, Marc Tollis, Danny E. Miller
There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccccecf4aa9964387b04c41961eb88f4
https://doi.org/10.1101/2023.04.03.535372
https://doi.org/10.1101/2023.04.03.535372
Akademický článek
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Akademický článek
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Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 8, Pp 2479-2487 (2016)
We have previously described a forward genetic screen in mice for abnormalities of brain development. Characterization of two hydrocephalus mutants by whole-exome sequencing after whole-genome SNP mapping revealed novel recessive mutations in Dnaaf1
Externí odkaz:
https://doaj.org/article/119be42d738f4e0ba4dc954442a14389
Autor:
Damon T. Jacobs, Luciane M. Silva, Bailey A. Allard, Michael P. Schonfeld, Anindita Chatterjee, George C. Talbott, David R. Beier, Pamela V. Tran
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 7, Pp 789-798 (2016)
Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling pathways. Ciliary dysfunction underlies ciliopathies, which are genetic syndromes that manifest multiple clinical features, including renal cystic disease an
Externí odkaz:
https://doaj.org/article/eb8da6f0e5b94b32bd21bb0d02517836