Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R. Andres Parra Sperberg"'
Autor:
Sean A. Hunter, Brianna J. McIntosh, Yu Shi, R. Andres Parra Sperberg, Chie Funatogawa, Louai Labanieh, Erin Soon, Hannah C. Wastyk, Nishant Mehta, Catherine Carter, Tony Hunter, Jennifer R. Cochran
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Hunter et al. engineer a high affinity, soluble variant of leukemia inhibitory factor receptor (LIFR) to serve as a ligand trap for the LIF cytokine. They further demonstrate that this engineered LIFR exhibits improved affinity relative to the wild-t
Externí odkaz:
https://doaj.org/article/c3dd515a153e4ff89d47ae646b6e90b2
Autor:
Nishant Mehta, Sainiteesh Maddineni, Irimpan I. Mathews, R. Andres Parra Sperberg, Po-Ssu Huang, Jennifer R. Cochran
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2509-2516.e5 (2019)
Summary: V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint protein that inhibits the T cell response against cancer. Similar to PD-1 and CTLA-4, a blockade of VISTA promotes tumor clearance by the immune sys
Externí odkaz:
https://doaj.org/article/f011ad8fa1e64bc6a8e84f5bac36f9ec
Autor:
Andrew M. Watkins, Po-Ssu Huang, Hannah K. Wayment-Steele, John J Nicol, Eterna Participants, Roger Wellington-Oguri, Do Soon Kim, Rhiju Das, Christian A Choe, R Andres Parra Sperberg
Publikováno v:
Nucleic Acids Research
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery, and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely unexplored strategy to reduce mRNA hydrolysis is to redesign RNAs to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3ccd11ba7fe72a76cf66277a3633e3
http://europepmc.org/articles/PMC8499941
http://europepmc.org/articles/PMC8499941
Autor:
R Andres Parra Sperberg, Stephanie Hanna, Bradley L. Pentelute, Po-Ssu Huang, Chelsea K Longwell, Nina Hartrampf, Jennifer R. Cochran
Publikováno v:
ACS Chem Biol
The glucagon-like peptide 1 receptor (GLP-1R) is a class B G-protein coupled receptor (GPCR) and diabetes drug target expressed mainly in pancreatic β-cells that, when activated by its agonist glucagon-like peptide 1 (GLP-1) after a meal, stimulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4038d4cceef44f9ea7c6e7f217ec8
https://doi.org/10.1021/acschembio.0c00722
https://doi.org/10.1021/acschembio.0c00722
Autor:
R Andres Parra Sperberg, Sean A. Hunter, Yu Shi, Tony Hunter, Nishant Mehta, Chie Funatogawa, Louai Labanieh, Erin Soon, Brianna J. McIntosh, Jennifer R. Cochran, Hannah C Wastyk, Catherine Carter
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Leukemia inhibitory factor (LIF), a cytokine secreted by stromal myofibroblasts and tumor cells, has recently been highlighted to promote tumor progression in pancreatic and other cancers through KRAS-driven cell signaling. We engineered a high affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781b055346af0cb96033e1edfee9c7b2
http://europepmc.org/articles/PMC8041770
http://europepmc.org/articles/PMC8041770
Autor:
Nishant Mehta, Robert B. Lee, John L. Silberstein, Louai Labanieh, Sean A. Hunter, Sainiteesh Maddineni, Amanda Lauren Rabe, Caitlyn L. Miller, Ryan L. Kelly, Jennifer R. Cochran, R Andres Parra Sperberg
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db36293efb6560050533a9e0ef106c5c
http://europepmc.org/articles/PMC7494997
http://europepmc.org/articles/PMC7494997
Autor:
Jiaxiang Wu, Cesar P Marquez, Po-Ssu Huang, Jennifer R. Cochran, R Andres Parra Sperberg, E. Alejandro Sweet-Cordero, Kim Jun Woo, Won G Bae
Publikováno v:
Proc Natl Acad Sci U S A
Interleukin-6 (IL-6) family cytokines signal through multimeric receptor complexes, providing unique opportunities to create novel ligand-based therapeutics. The cardiotrophin-like cytokine factor 1 (CLCF1) ligand has been shown to play a role in can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebaf2b84f54f9d685cb5270e1812dde4
https://pubmed.ncbi.nlm.nih.gov/32522868
https://pubmed.ncbi.nlm.nih.gov/32522868
Autor:
Cheryl H. Chang, Deepti Kannan, Sean A. Hunter, R Andres Parra Sperberg, Spencer C. Alford, Aaron C. Mitchell, Jennifer R. Cochran
Publikováno v:
ACS Chemical Biology. 13:66-72
Dysregulated activity of the protease matriptase is a key contributor to aggressive tumor growth, cancer metastasis, and osteoarthritis. Methods for the detection and quantification of matriptase activity and inhibition would be useful tools. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858ec02e1cc91dd550dcceff5041014c
https://doi.org/10.1021/acschembio.7b00715
https://doi.org/10.1021/acschembio.7b00715
Autor:
R Andres Parra Sperberg, Po-Ssu Huang, Nishant Mehta, Sainiteesh Maddineni, Irimpan I. Mathews, Jennifer R. Cochran
V-domain Ig Suppressor of T cell Activation (VISTA) is an immune checkpoint protein that inhibits the T - cell response against cancer. Similar to PD-1 and CTLA-4, antibodies that block VISTA signaling can release the brakes of the immune system and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5801c7c22f17249336fb66ee1950f776
https://doi.org/10.1101/597716
https://doi.org/10.1101/597716
Autor:
Sean A. Hunter, Cheryl H. Chang, R Andres Parra Sperberg, Jennifer R. Cochran, Aaron C. Mitchell, Deepti Kannan
Dysregulated matriptase activity has been established as a key contributor to cancer progression through its activation of growth factors, including the hepatocyte growth factor (HGF). Despite its critical role and prevalence in many human cancers, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8554dbd78588e046f882052d0cb3a0
https://europepmc.org/articles/PMC5892588/
https://europepmc.org/articles/PMC5892588/