Zobrazeno 1 - 6
of 6
pro vyhledávání: '"R. Andrea Fan"'
Autor:
Tony Muchamuel, R. Andrea Fan, Janet L. Anderl, Darrin J. Bomba, Henry W. B. Johnson, Eric Lowe, Brian B. Tuch, Dustin L. McMinn, Beatriz Millare, Christopher J. Kirk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Zetomipzomib (KZR-616) is a selective inhibitor of the immunoproteasome currently undergoing clinical investigation in autoimmune disorders. Here, we characterized KZR-616 in vitro and in vivo using multiplexed cytokine analysis, lymphocyte activatio
Externí odkaz:
https://doaj.org/article/b8472904a1e148a78a2945fec4d80181
Publikováno v:
Cells, Vol 11, Iss 1, p 9 (2021)
Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of multiple B-cell malignancies. These agents have also been employed with success in the treatment of patients with autoimmune diseases and immune-mediated d
Externí odkaz:
https://doaj.org/article/d5e428ce077b48d189db01fb2f54a031
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11595, p 11595 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The proteasome is responsible for mediating intracellular protein degradation and regulating cellular function with impact on tumor and immune effector cell biology. The proteasome is found predominantly in two forms, the constitutive proteasome and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab0cd09e028882cc6f88f3bb34ac3d5
https://www.mdpi.com/1422-0067/22/21/11595
https://www.mdpi.com/1422-0067/22/21/11595
Autor:
R. Andrea Fan, Yu Qian, Dustin McMinn, Eric Lowe, Brian B Tuch, Christopher J. Kirk, Henry Johnson
Publikováno v:
Cancer Research. 81:2226-2226
Blockade of secreted and transmembrane protein translocation into the endoplasmic reticulum represents a potentially multifactorial approach to inhibiting tumor growth. We have shown that small molecule inhibitors of the Sec61 translocon can inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22303a36e453e70e31958fd0799e4c96
https://doi.org/10.1158/1538-7445.am2021-2226
https://doi.org/10.1158/1538-7445.am2021-2226
Autor:
Yu Qian, Jennifer A. Whang, Jing Jiang, Brian B. Tuch, Tony Muchamuel, Beatriz Millare, Christopher J. Kirk, Patricia Zuno, R. Andrea Fan, Dustin McMinn, Henry Johnson, Eric Lowe
Publikováno v:
Journal of Clinical Oncology. 38:3582-3582
3582 Background: Secreted and transmembrane proteins play key roles in malignant transformation and growth, including in autocrine growth factor expression, receptor oncogene signaling, and immune system evasion. Biogenesis of these proteins involves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e65da92d224c73a4f87cdf2ca2aa0524
https://doi.org/10.1200/jco.2020.38.15_suppl.3582
https://doi.org/10.1200/jco.2020.38.15_suppl.3582
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