Zobrazeno 1 - 10
of 158
pro vyhledávání: '"R. A. Reisfeld"'
Autor:
R. A. Reisfeld
New information is developing so rapidly in the entire field of immunology that one is unable to remain abreast of all advancing fronts. In many cases, consider able information has accumulated as the result of the efforts of many investigators, bu
Publikováno v:
The Journal of Immunology. 158:4413-4421
The neural cell adhesion molecule L1 has been implicated in a variety of neurologic processes, including neuritogenesis and cerebellar cell migration. Here we propose an expanded role for this cell adhesion molecule in the human immune system based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0996dbde9d1417a7d852f833ef38976e
https://doi.org/10.4049/jimmunol.158.9.4413
https://doi.org/10.4049/jimmunol.158.9.4413
Publikováno v:
The Journal of Immunology. 157:1582-1588
mAb against GD3 ganglioside demonstrate homophilic binding in which soluble anti-GD3 mAb bind, through the GD3 binding site, to a VH idiotope (designated IdHOM) on solid phase anti-GD3 mAb. In this way, homophilic binding provides a mechanism for amp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef07de9e5a4e2d4c8f5a1ecff0f77383
https://doi.org/10.4049/jimmunol.157.4.1582
https://doi.org/10.4049/jimmunol.157.4.1582
Publikováno v:
The Journal of Immunology. 144:1382-1386
A mouse/human chimeric antibody (ch14.18) was developed that reacts with the disialoganglioside GD2 on the surface of tumor cells of neuroectodermal origin. ch14.18 has the constant regions of a human IgG1 antibody and was expressed in a murine hybri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3849d5bd1aaad9dc81c711571bce93b5
https://doi.org/10.4049/jimmunol.144.4.1382
https://doi.org/10.4049/jimmunol.144.4.1382
Autor:
J M, Ruehlmann, R, Xiang, A G, Niethammer, Y, Ba, U, Pertl, C S, Dolman, S D, Gillies, R A, Reisfeld
Publikováno v:
Cancer research. 61(23)
The induction of a CTL response capable of eradicating disseminated tumor metastases and the establishment of a persistent tumor-protective immunity remain major goals of cancer immunotherapy. Here, we demonstrate for the first time that the combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7ac4a9653af1b119d081e5844fb4155
https://pubmed.ncbi.nlm.nih.gov/11731434
https://pubmed.ncbi.nlm.nih.gov/11731434
Autor:
M, Imboden, K R, Murphy, A L, Rakhmilevich, Z C, Neal, R, Xiang, R A, Reisfeld, S D, Gillies, P M, Sondel
Publikováno v:
Cancer research. 61(4)
The huKS1/4-IL2 fusion protein, directed against the human epithelial cell adhesion molecule (huEpCAM) has been shown to induce a strong CD8+ T-cell-dependent, natural killer (NK) cell-independent, antitumor response in mice bearing the huEp-CAM-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4809b931f546eac5038a01a26d614b9c
https://pubmed.ncbi.nlm.nih.gov/11245457
https://pubmed.ncbi.nlm.nih.gov/11245457
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(7)
Eradication of established colon carcinoma metastases is a major goal for adjuvant immunotherapy of this disease. This was accomplished in a murine model by targeting IL-2 to the tumor microenvironment with a recombinant Ab-IL-2 fusion protein (huKS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58c3ad20a119a2b3ce8f9dd33bd5def2
https://pubmed.ncbi.nlm.nih.gov/10490962
https://pubmed.ncbi.nlm.nih.gov/10490962
Publikováno v:
Pharmacologytherapeutics. 80(3)
Recombinant antibody-cytokine fusion proteins are immunocytokines that achieve high cytokine concentrations in the tumor microenvironment and thereby effectively stimulate cellular immune responses against malignancies. The activation and expansion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47ef1a0cdb3a6f4692ed48622aace897
https://pubmed.ncbi.nlm.nih.gov/9888698
https://pubmed.ncbi.nlm.nih.gov/9888698
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(11)
The antiganglioside GD2 monoclonal antibody 14G2a (Ab1) served as an immunogen to generate the anti-idiotype (anti-Id) 1A7 (IgG1,kappa), which mimics GD2 both antigenically and biologically. Anti-Id 1A7 induced anti-GD2 antibodies in mice and rabbits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e64d1ece9b68adffbb96724de0f01c05
https://pubmed.ncbi.nlm.nih.gov/9815586
https://pubmed.ncbi.nlm.nih.gov/9815586
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(12)
IL-12 is a complex cytokine in both its structure and its range of biologic activities. Fusions of this heterodimeric molecule with an intact antitumor Ab were made to test the feasibility and efficacy of targeting IL-12 to tumors to elicit a local i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::607e86fb7e904ed961d923fc9e0e7d17
https://pubmed.ncbi.nlm.nih.gov/9637539
https://pubmed.ncbi.nlm.nih.gov/9637539