Zobrazeno 1 - 10
of 880
pro vyhledávání: '"R. A. Pearson"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract As photoreceptor cells die during retinal degeneration, the surrounding microenvironment undergoes significant changes that are increasingly recognized to play a prominent role in determining the efficacy of therapeutic interventions. Chondr
Externí odkaz:
https://doaj.org/article/e8e8ecf8badd408f8a7314d78784c6df
Autor:
R. A. Pearson, A. Gonzalez-Cordero, E. L. West, J. R. Ribeiro, N. Aghaizu, D. Goh, R. D. Sampson, A. Georgiadis, P. V. Waldron, Y. Duran, A. Naeem, M. Kloc, E. Cristante, K. Kruczek, K. Warre-Cornish, J. C. Sowden, A. J. Smith, R. R. Ali
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Transplantation of healthy photoreceptor cells has been shown to rescue blindness. Here, the authors show that rather than donor cells integrating into the host retina, the predominant mechanism underlying this rescue involves exchange of cytoplasmic
Externí odkaz:
https://doaj.org/article/b15e33f7b89f4b918a0a570c180b0b86
Autor:
E. L. West, R. A. Pearson, Y. Duran, A. Gonzalez-Cordero, R. E. Maclaren, A. J. Smith, J. C. Sowden, R. R. Ali
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Degeneration of the neural retina is the leading cause of untreatable blindness in the developed world. Stem cell replacement therapy offers a novel strategy for retinal repair. Postmitotic photoreceptor precursors derived from the early postnatal (P
Externí odkaz:
https://doaj.org/article/9edac738641e4c0da01e9a8e0eeffbd4
Autor:
R. A. Pearson, A. C. Barber, E. L. West, R. E. Maclaren, Y. Duran, J. W. Bainbridge, J. C. Sowden, R. R. Ali
Publikováno v:
Cell Transplantation, Vol 19 (2010)
Diseases culminating in photoreceptor loss are a major cause of untreatable blindness. Transplantation of rod photoreceptors is feasible, provided donor cells are at an appropriate stage of development when transplanted. Nevertheless, the proportion
Externí odkaz:
https://doaj.org/article/047abcd08ebc43c88c765a4c8e1c2952
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1266-1277 (2023)
While useful for fundamental in vitro studies, monolayer cell cultures are not physiologically relevant. Spheroids, a complex three‐dimensional (3D) structure, more closely resemble in vivo tumor growth. Spheroids allow the results obtained relatin
Externí odkaz:
https://doaj.org/article/c5f976708f564b8989b4d05dc7b0ceae
Autor:
Ella F.S. Guy, Jaimey A. Clifton, Jennifer L. Knopp, Lui R. Holder-Pearson, J. Geoffrey Chase
Publikováno v:
HardwareX, Vol 16, Iss , Pp e00489- (2023)
Respiratory model-based methods require datasets containing enough dynamics to ensure model identifiability for development and validation. Rapid expiratory occlusion has been used to identify elastance and resistance within a single breath. Currentl
Externí odkaz:
https://doaj.org/article/845b1afa8ec746d7903ab0eb0b1b4c36
Publikováno v:
Frontiers in Psychology, Vol 14 (2023)
IntroductionThis work explores the use of an automated facial coding software - FaceReader - as an alternative and/or complementary method to manual coding.MethodsWe used videos of parents (fathers, n = 36; mothers, n = 29) taken from the Avon Longit
Externí odkaz:
https://doaj.org/article/757e9da855474610af5223bae2065dcc
Autor:
Ella F. S. Guy, Jaimey A. Clifton, Jennifer L. Knopp, Lui R. Holder-Pearson, J. Geoffrey Chase
Publikováno v:
Sensors, Vol 23, Iss 24, p 9774 (2023)
(1) Background: Technically, a simple, inexpensive, and non-invasive method of ascertaining volume changes in thoracic and abdominal cavities are required to expedite the development and validation of pulmonary mechanics models. Clinically, this meas
Externí odkaz:
https://doaj.org/article/6f4fe62bc97e46a2853bdc19ae8ba199
Autor:
Sangma, Annastasia A., Akoijam, Brogen Singh, Devi, P. Amrita, Singh, Kh. Sonarjit, R. L., Pearson, Dhali, Sneha
Publikováno v:
IASSI Quarterly; Oct-Dec2024, Vol. 15 Issue 4, p64-72, 9p
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2100 (2023)
Immunotherapy represents an attractive avenue for cancer therapy due to its tumour specificity and relatively low frequency of adverse effects compared to other treatment modalities. Despite many advances being made in the field of cancer immunothera
Externí odkaz:
https://doaj.org/article/100563c7a4c142d3bfc557fff770979c