Zobrazeno 1 - 10
of 328
pro vyhledávání: '"R. A. McKinney"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Synaptopodin, an actin-associated protein found in a subset of dendritic spines in telencephalic neurons, has been described to influence both functional and morphological plasticity under various plasticity paradigms. Synaptopodin is necessary and s
Externí odkaz:
https://doaj.org/article/1860d2bf22484f0ebb784378cc65fda1
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Synaptopodin (SP), an actin-associated protein found in telencephalic neurons, affects activity-dependant synaptic plasticity and dynamic changes of dendritic spines. While being required for long-term depression (LTD) mediated by metabotrop
Externí odkaz:
https://doaj.org/article/6c0d77d8df7f419c86ef43006a47beb8
Publikováno v:
Journal of Aging Research, Vol 2013 (2013)
Reduced estrogens, either through aging or postsurgery breast cancer treatment with the oral nonsteroidal aromatase inhibitor letrozole, are linked with declined cognitive abilities. However, a direct link between letrozole and neuronal deficits indu
Externí odkaz:
https://doaj.org/article/225f5c7fe9c5413280d89dbf6a5e2274
Autor:
Brenda Toscano Márquez, Tsz Chui Sophia Leung, Jeanette Hui, François Charron, R. Anne McKinney, Alanna J. Watt
Publikováno v:
Neurobiology of Disease, Vol 183, Iss , Pp 106157- (2023)
Mitochondrial deficits have been observed in animal models of Autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and in patient-derived fibroblasts. We investigated whether mitochondrial function could be restored in Sacs−/− mice,
Externí odkaz:
https://doaj.org/article/028672de4760470a8af518d9fa8da142
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Endomembrane alkali cation (Na+, K+)/proton (H+) exchangers (eNHEs) are increasingly associated with neurological disorders. These eNHEs play integral roles in regulating the luminal pH, processing, and trafficking of cargo along the secretory (Golgi
Externí odkaz:
https://doaj.org/article/1500ff46b15248199dfdb11cf09c58c5
Autor:
Brenda Toscano Márquez, Anna A. Cook, Max Rice, Alexia Smileski, Kristen Vieira-Lomasney, François Charron, R. Anne McKinney, Alanna J. Watt
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Patterned cell death is a common feature of many neurodegenerative diseases. In patients with autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and mouse models of ARSACS, it has been observed that Purkinje cells in anterior cerebell
Externí odkaz:
https://doaj.org/article/be178d3a28794133b63c8e92df9a0180
Autor:
T. Lewis, W. Truog, L. Nelin, N. Napolitano, R. L. McKinney, and on behalf of The BPD Collaborative
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Infants with severe bronchopulmonary dysplasia (BPD) are commonly treated with off-label drugs due to lack of approved therapies. To prioritize drugs for rigorous efficacy and safety testing, it is important to describe exposure patterns
Externí odkaz:
https://doaj.org/article/face4867ada74ce7be8cf3ce845050e4
Autor:
Alina Ilie, Andy Y.L. Gao, Annie Boucher, Jaeok Park, Albert M. Berghuis, Mariëtte J.V. Hoffer, Yvonne Hilhorst-Hofstee, R. Anne McKinney, John Orlowski
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 187-204 (2019)
Loss-of-function mutations in the recycling endosomal (Na+,K+)/H+ exchanger gene SLC9A6/NHE6 result in overacidification and dysfunction of endosomal-lysosomal compartments, and cause a neurodevelopmental and degenerative form of X-linked intellectua
Externí odkaz:
https://doaj.org/article/783c4bd5a3b749d3b6d019056efbdbee
Autor:
Dusica Maysinger, Issan Zhang, Pei You Wu, Marten Kagelmacher, Haiming Daniel Luo, Jayachandran N. Kizhakkedathu, Jens Dernedde, Matthias Ballauff, Rainer Haag, Adeola Shobo, Gerhard Multhaup, R. Anne McKinney
Publikováno v:
ACS Chemical Neuroscience. 14:677-688
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e87464ce8bbd8f9b439924febcc2aaf
https://doi.org/10.1021/acschemneuro.2c00558
https://doi.org/10.1021/acschemneuro.2c00558
Publikováno v:
eLife, Vol 8 (2019)
Exposing chicks to one hour of light during the night disrupts the release of a hormone that is needed by cells in the developing brain to survive.
Externí odkaz:
https://doaj.org/article/6569427055e74b85a014961611f1d903