Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R. A. Mathies"'
Publikováno v:
Electrophoresis. 22(18)
This review focuses on some recent advances in realizing microfabricated capillary array electrophoresis (microCAE). In particular, the development of a novel rotary scanning confocal fluorescence detector has facilitated the high-speed collection of
Publikováno v:
Clinical chemistry. 47(9)
Genetic analysis of microsatellite DNA is a powerful tool used in linkage analysis, gene mapping, and clinical diagnosis. To address the expanding needs of studies of short tandem repeats (STRs), we demonstrated high-performance STR analysis on a hig
Publikováno v:
BioTechniques. 30(1)
The collection and conversion of 4-color fluorescent genotyping data from capillary array electrophoresis microchip devices and its conversion to a format easily and rapidly analyzed by Genetic Profiler genotyping software is presented. Microchip flu
Publikováno v:
Electrophoresis. 21(12)
A single nucleotide polymorphism (SNP) typing assay is developed and evaluated on a microfabricated capillary array electrophoresis system. Using fluorescently labeled allele-specific primers, the S65C (193A--T) substitution associated with hereditar
Publikováno v:
Electrophoresis. 20(7)
We have constructed a rotary confocal fluorescence scanner and capillary array electrophoresis system that is designed to analyze over 1000 DNA sequencing or fragment sizing separations in parallel. Capillaries are arranged around the surface of a cy
Autor:
I, Kheterpal, R A, Mathies
Publikováno v:
Analytical chemistry. 71(1)
Publikováno v:
The Journal of biological chemistry. 273(38)
Spectral tuning by visual pigments involves the modulation of the physical properties of the chromophore (11-cis-retinal) by amino acid side chains that compose the chromophore-binding pocket. We identified 12 amino acid residues in the human blue co
Publikováno v:
Analytical chemistry. 69(11)
Capillary array electrophoresis (CAE) chips have been designed and fabricated with the capacity to rapidly (160 s) analyze 12 different samples in parallel. Detection of all lanes with 0.3 s temporal resolution was achieved using a laser-excited conf
Publikováno v:
Analytical biochemistry. 243(1)
Energy transfer (ET) fluorescent primers are significantly superior to single dye-labeled primers for DNA sequencing and multiplex genetic analyses (Ju, J., Glazer, A. N., and Mathies, R. A. (1996) Nature Med. 2, 246-249). We describe here ET primers
Autor:
R A, Mathies
Publikováno v:
Methods in enzymology. 246