Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R. A. Majack"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 268:H1133-H1138
During the development of pulmonary hypertension, vascular cell proliferation closely parallels the rise in pulmonary intravascular pressure. The possible direct physical effect that elevated pressures may have on inducing vascular cell proliferation
Autor:
R A, Majack, N A, Grieshaber, C L, Cook, M C, Weiser, R C, McFall, S S, Grieshaber, M A, Reidy, C F, Reilly
Publikováno v:
Journal of cellular physiology. 167(1)
A variety of evidence suggests that vascular smooth muscle cells (SMC) exhibit a more immature phenotype when stimulated by injury to replicate in the adult. One growth characteristic common to immature (embryonic, fetal, and neonatal) SMC is a marke
Publikováno v:
The American journal of physiology. 269(5 Pt 2)
Local release of mitogenic and chemotactic signals during angioplasty-induced vascular injury may initiate restenosis. We investigated whether mechanical injury to vascular smooth muscle cells (VSMC) results in the release of biologically active pept
Autor:
R A Majack
Publikováno v:
The Journal of clinical investigation. 95(2)
Vascular smooth muscle cells (SMC) isolated from embyronic and early fetal (e13-e18) rat aortas exhibit an "embryonic growth phenotype" in culture (Cook, C. L., M. C. M. Weiser, P. E. Schwartz, C. L. Jones, and R. A. Majack. 1994. Circ. Res. 74:189-1
Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries
Publikováno v:
The Journal of clinical investigation. 85(6)
A large percentage of vascular reconstructions, endarterectomies, and angioplasties fail postoperatively due to thrombosis and restenosis. Many of these failures are thought to result from an inability of the vascular endothelium to adequately regene
Autor:
P Bornstein, R A Majack
Publikováno v:
The Journal of Cell Biology
The effect of heparin on the biosynthetic phenotype of rat vascular smooth muscle cells (SMC) was investigated in vitro. Addition of heparin to the culture medium of early passage rat SMC resulted in a marked (3-15-fold) increase of a cell layer-asso
Publikováno v:
Journal of Biological Chemistry. 262:8821-8825
We have investigated the regulation of mRNA levels for thrombospondin, a platelet-derived growth factor (PDGF)-regulated secreted glycoprotein, in cultures of rat vascular smooth muscle cells (SMC). A thrombospondin cDNA hybridizes to a single 5.5-ki
Autor:
R A Majack
Publikováno v:
The Journal of Cell Biology
In culture, vascular smooth muscle cells (SMC) grow in a "hill-and-valley" (multilayered) pattern of organization. We have studied the growth, behavioral organization, and biosynthetic phenotype of rat aortic SMC exposed to purified platelet-derived
Autor:
R A Majack, L V Goodman
Publikováno v:
Journal of Biological Chemistry. 264:5241-5244
Transforming growth factor-beta (TGF-beta) is a bifunctional, density-dependent regulator of vascular smooth muscle cell (SMC) proliferation in vitro (at sparse densities SMC are growth-inhibited by the peptide, whereas at confluent densities TGF-bet
Publikováno v:
Histochemistry. 63:23-33
The cytochemical distribution of nonspecific membrane ATPase activity in the epithelial membranes of the thin limbs of the loops of Henle of rat nephrons was studied at the ultrastructural level. Membrane ATPase activity was localized in the luminal,