Zobrazeno 1 - 10 of 71 pro vyhledávání: '"R. A. Lew"'
1
Synthetic inhibitors of endopeptidase EC 3.4.24.15: potency and stability in vitro and in vivo
Autor: L. A. Pipolo, L. Lakat, Fumihiro Tomoda, R A Lew, Alexander Ian Smith, J. H. Boublik, Roger G. Evans
Publikováno v: Scopus-Elsevier
1. The role of the metalloendopeptidase EC 3.4.24.15 (EP 24.15) in peptide metabolism in vivo is unknown, in part reflecting the lack of a stable enzyme inhibitor. The most commonly used inhibitor, N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-p-ami
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e84babc617ea920c62e03139de672b
https://doi.org/10.1111/j.1476-5381.1996.tb15533.x
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2
Evaluating additives and impurities in zinc electrowinning
Autor: R. W. Lew, J. A. González-Domínguez
Publikováno v: JOM. 47:34-37
The zinc electrowinning (EW) process is very sensitive to the presence of impurities. There is only one EW plant in the world that we know of that operates at moderate current efficiency and deposition times without using any additives. All the other
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3326271cc1eefd2114b031d210e6641a
https://doi.org/10.1007/bf03221128
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3
Report on a conference on motor prostheses for workplace mobility of paraplegic patients in North America
Autor: C Kantor, Brian J. Andrews, M Solomonow, E B Marsolais, R D Lew, K T Ragnarsson
Publikováno v: Spinal Cord. 31:439-456
On May 18, 1992 a symposium at Case Western Reserve University in Cleveland, Ohio, USA had the goal of defining the tasks needed to reach clinical utility of investigational neural prosthetic ambulation devices. The characteristics and stage of devel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1d756357380f25bfaab83b255032c59
https://doi.org/10.1038/sc.1993.73
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6
Root Hair Electrophysiology
Autor: R. R. Lew
Publikováno v: Plant Cell Monographs ISBN: 9783540794042
In this review, the value of root hairs as a model system for a broad range of electrophysiological experiments is highlighted by an introductory case study of their use for in situ measurements of vacuolar electrophysiology. Then, the basic tenets o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::277d5babd542d43f3d1ab369d3d2c302
https://doi.org/10.1007/978-3-540-79405-9_9
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7
Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression
Autor: L, Burchill, E, Velkoska, R G, Dean, R A, Lew, A I, Smith, V, Levidiotis, L M, Burrell
Publikováno v: Experimental physiology. 93(5)
Patients with kidney failure are at high risk of a cardiac death and frequently develop left ventricular hypertrophy (LVH). The mechanisms involved in the cardiac structural changes that occur in kidney failure are yet to be fully delineated. Angiote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7328cea84600f5e6ff78f90503ab9a7d
https://pubmed.ncbi.nlm.nih.gov/18223026
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8
Role of recurrent hydrophobic residues in catalysis of helix formation by T cell-presented peptides in the presence of lipid vesicles
Autor: S Lu, V E Reyes, R A Lew, J Anderson, J Mole, R E Humphreys, T Ciardelli
Publikováno v: The Journal of Immunology. 145:899-904
We tested the hypothesis that the recurrence of hydrophobic amino acids in a polypeptide at positions falling in an axial, hydrophobic strip if the sequence were coiled as an alpha helix, can lead to helical nucleation on a hydrophobic surface. The h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8c529d7ee0d3643d7d06bccd0ae9655
https://doi.org/10.4049/jimmunol.145.3.899
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9
Use of β-Amino Acids in the Design of Substrate-Based Peptidase Inhibitors
Autor: Michael J. Lew, Patrick Perlmutter, Marie-Isabel Aguilar, K. M. Stewart, M. F. Harte, E. Boulos, S. B. Reeve, Silas Bond, M. U. Norman, R. A. Lew, A. I. Smith
Publikováno v: Peptides: The Wave of the Future ISBN: 9789401039055
s-Amino acids contain an extra carbon between the amino and carboxy-termini; this modification renders the adjacent peptide bond resistant to hydrolysis [1,2]. We hypothesize that substitution of the residues at the scissile bond with s-amino acids c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76c507ec28d0f35235999fae26b2c889
https://doi.org/10.1007/978-94-010-0464-0_257
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10
Bradykinin analogues with beta-amino acid substitutions reveal subtle differences in substrate specificity between the endopeptidases EC 3.4.24.15 and EC 3.4.24.16
Autor: R A, Lew, E, Boulos, K M, Stewart, P, Perlmutter, M F, Harte, S, Bond, M I, Aguilar, A I, Smith
Publikováno v: Journal of peptide science : an official publication of the European Peptide Society. 6(9)
The closely related zinc metalloendopeptidases EC 3.4.24.15 (EP24.15) and EC 3.4.24.16 (EP24.16) cleave many common substrates, including bradykinin (BK). As such, there are few substrate-based inhibitors which are sufficiently selective to distingui
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73f4969120f7dddf6f7a2aa6815500de
https://pubmed.ncbi.nlm.nih.gov/11016880
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