Zobrazeno 1 - 10
of 19
pro vyhledávání: '"R. A. Kopaladze"'
Autor:
R A, Kopaladze
Publikováno v:
Uspekhi fiziologicheskikh nauk. 48(1)
Analysis of scientific works from the creation of an experimental model of diabetes before discovery insulin was done. Emphasized is the priority of the Russian pathologist L. W. Sobolew (1876-1919) in the discovery of the endocrine function of the p
Publikováno v:
Neurochemical Journal. 7:45-55
We studied the effects of single moderate hypobaric hypoxia (HBH, 10% O2, 60 min) on the central cholinergic systems. For this purpose, we determined the activity of the marker of cholinergic neurons choline acetyltransferase (ChAT) and the protein c
Publikováno v:
Bulletin of Experimental Biology and Medicine. 147:400-404
Single exposure to moderate (10% O(2)) hypobaric, normobaric, and intermittent hypoxia is followed by a preconditioning response of the organism. The mechanisms for immediate adaptation are activated during the hypoxic period. Intermittent reoxygenat
Autor:
R A, Kopaladze
Publikováno v:
Uspekhi fiziologicheskikh nauk. 45(3)
It is shown that major achievements in the history of biomedicine, obtained in experiments on animals: the discovery of blood circulation, the achievements of microbiology and development of the concept of immunity, the discovery of reflex and the do
Autor:
R A, Kopaladze
Publikováno v:
Uspekhi fiziologicheskikh nauk. 40(3)
Ethic aspects of biomedical experiment evolution from Alkmaion to Pavlov, are analysed. The history of reflexes in the paradigm of mechanitsism and antropomorphism is reinterpreted. It is emphasized that animal life and their behaviour exceed the bou
Autor:
R A, Kopaladze
Publikováno v:
Uspekhi fiziologicheskikh nauk. 37(2)
The review considers the history of selection of minipigs convenient for maintenance in scientific laboratories. It is shown that minipigs are suitable for studies of wide range of problems and there are perspectives of their use for xenotransplantat
Autor:
R A, Kopaladze
Publikováno v:
Uspekhi fiziologicheskikh nauk. 35(2)
The origin of laboratory animal science was called forth by violent development of experimental biology and medicine in the XIX century on the one hand, and on the other hand by the necessity to have standard healthy animals for experiments with stri
Autor:
R A, Kopaladze
Publikováno v:
Uspekhi fiziologicheskikh nauk. 31(3)
In this paper there are shown chemical and physical methods of euthanasia of vertebrate animals. All methods are divided into three categories: A) Acceptable methods of euthanasia, B) methods acceptable only for unconscious animals, C) methods that a
Autor:
R A, Kopaladze
Publikováno v:
Uspekhi fiziologicheskikh nauk. 29(4)
Legislation and rules for animal experiments in many countries are proposed. Activities of international and national organizations, committees and administrative authorities are described. The importance of the three Rs principle and alternative met
Publikováno v:
Bulletin of Experimental Biology and Medicine. 96:1664-1667
Epileptiform seizures are a characteristic manifestation of the toxic action of oxygen (hyperoxia) on the brain [9, 13]. An essential role in seizure formation can be played by damage to the serotoninergic system of the brain [7]. However, the concre