Zobrazeno 1 - 10
of 31
pro vyhledávání: '"R. A. Insel"'
Publikováno v:
Infection and Immunity. 69:3335-3342
From five mice immunized withEscherichia coliK1 bacteria, we produced 12 immunoglobulin M hybridomas secreting monoclonal antibodies (MAbs) that bind toNeisseria meningitidisgroup B (NMGB). The 12 MAbs also bound the capsular polysaccharide (PS) ofE.
Publikováno v:
The Journal of Immunology. 159:1068-1071
The extensive proliferation that B lymphocytes undergo in germinal centers could compromise generation of long term B cell memory if there occurs shortening of the telomeres of germinal center B cells with cell division. Telomere length, which is tho
Publikováno v:
The Journal of Immunology. 150:4985-4995
VH6, the most 3' human H chain V region gene, is preferentially expressed in the preimmune repertoire of the developing human fetus. To determine whether VH6 contributes to the immune repertoire, we amplified and sequenced from human spleen RNA VH6 r
Publikováno v:
Clinical and Experimental Immunology. 80:263-267
SUMMARY The participation of human IgD class antibody in local immune responses of breast tissue was studied by analysing the sera-to-milk ratios of total IgD, IgM, IgA, IgG isotypes and albumin found in matched samples, and by analysing the sera-to-
Autor:
A E, Pugh-Bernard, G J, Silverman, A J, Cappione, M E, Villano, D H, Ryan, R A, Insel, I, Sanz
Publikováno v:
The Journal of clinical investigation. 108(7)
The study of human B cell tolerance has been hampered by difficulties in identifying a sizable population of autoreactive B lymphocytes whose fate could be readily determined. Hypothesizing that B cells expressing intrinsically autoreactive antibodie
Publikováno v:
Immunology. 93(2)
To study inherent properties of somatic hypermutation of human immunoglobulin genes in the absence of antigen selection, mutations of human non-productive VH6 rearrangements enriched by subtractive hybridization were characterized. Ten unique clones
Autor:
W. S. Varade, R. A. Insel
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783642719868
Affinity maturation of antibodies after immunization is a result of hypermutation of the variable region of immunoglobulin genes and an antigen selection process that preserves those B lymphocytes with mutated surface immunoglobulin (Ig) expressing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3adf04c05ad0b361993ae467fbf8ff3c
https://doi.org/10.1007/978-3-642-71984-4_4
https://doi.org/10.1007/978-3-642-71984-4_4
Autor:
R. A. Insel, M. H. Nahm
Publikováno v:
The Biology of Germinal Centers in Lymphoid Tissue ISBN: 9783662131435
As detailed in chapter 1, the germinal center can be histologically divided into a dark zone of proliferating centroblasts and a light zone of nonproliferating centrocytes.1–3 The dark zone, in proximity to the PALS, is populated by proliferating c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc9c201e5ae03f8e65e17315012a345
https://doi.org/10.1007/978-3-662-13141-1_3
https://doi.org/10.1007/978-3-662-13141-1_3
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(3)
The extensive proliferation that B lymphocytes undergo in germinal centers could compromise generation of long term B cell memory if there occurs shortening of the telomeres of germinal center B cells with cell division. Telomere length, which is tho
Publikováno v:
Blood. 89(3)
Relatively little is known about the relationship of lymphoid-associated gene expression to the proliferation and differentiation potential of early human bone marrow lymphoid progenitors. Surface expression of interleukin-7 (IL-7) receptor-alpha (IL