Výsledky vyhledávání - "R. A. Hiipakka"

The androgen receptor status of neuroendocrine cells in human benign and malignant prostatic tissue

Autor: S Y, Nakada, P A, di Sant'Agnese, R A, Moynes, R A, Hiipakka, S, Liao, A T, Cockett, P A, Abrahamsson

Publikováno v: Cancer research. 53(9)

Neuroendocrine (NE) cells containing neurosecretory granules, rich in various peptide hormones and biogenic amines, are components of the human prostate epithelium and prostatic adenocarcinomas. Neuroendocrine differentiation in prostatic adenocarcin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c03f2da85fff031d843613276daddef8
https://pubmed.ncbi.nlm.nih.gov/8481896

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Expression and function of normal and LNCaP androgen receptors in androgen-insensitive human prostatic cancer cells. Altered hormone and antihormone specificity in gene transactivation

Autor: J, Kokontis, K, Ito, R A, Hiipakka, S, Liao

Publikováno v: Receptor. 1(4)

The gene for the androgen receptor (AR) in the androgen-sensitive human prostate cancer cell line LNCaP has a single-base mutation that produces a threonine to alanine change in the androgen-binding domain. Androgen-insensitive prostatic cancer (PC-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::110d90a184e8f6327b3a25636db51e13
https://pubmed.ncbi.nlm.nih.gov/1668832

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Prostatic ductal system in rats: regional variation in morphological and functional activities

Autor: C, Lee, J A, Sensibar, S M, Dudek, R A, Hiipakka, S T, Liao

Publikováno v: Biology of reproduction. 43(6)

The rat prostate is a complex ductal system with branches and subbranches extending from one end to another. Owing to the relative distance of various regions of the duct from the urethra, the entire length of the ductal system can be arbitrarily div

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ef6fc4766468cf1a2461f57863b9278
https://pubmed.ncbi.nlm.nih.gov/2291926

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Polyamine-stimulated phosphorylation of prostatic spermine-binding protein is mediated only by cyclic AMP-independent protein kinases

Autor: R. A. Hiipakka, Khalil Ahmed, Alan T. Davis, Shutsung Liao, Said A. Goueli

Publikováno v: Biochemical Journal. 230:293-302

Spermine-binding protein (a rat ventral prostatic protein with high affinity for spermine) was phosphorylated in situ through the action of intrinsic cellular protein kinase(s), suggesting it to be a phosphoprotein in vivo. The purified protein serve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910ce6a769fdf59854be4d8ff63bf4c5
https://doi.org/10.1042/bj2300293

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Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis

Autor: Shutsung Liao, Saverio Bettuzzi, R A Hiipakka, P Gilna

Publikováno v: Biochemical Journal. 257:293-296

The concentrations of a small number of mRNAs in the rat ventral prostate increase after castration and then decrease upon androgen treatment. Since the repression of specific gene expression may be important in the regulation of organ growth, we hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb57df28879cd4f97ff13e0acbf450e2
https://doi.org/10.1042/bj2570293

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Intracellular inhibition of chromatin binding and transformation of androgen receptor by 3′-deoxyadenosine

Autor: R. A. Hiipakka, Shutsung Liao

Publikováno v: Journal of Biological Chemistry. 263:17590-17595

Incubation of minced rat ventral prostate with 3'-deoxyadenosine (3'-dA) prior to labeling with the androgen, tritiated 7 alpha, 17 alpha-dimethyl-19-nortestosterone, reduced the level of androgen receptor bound to chromatin and increased the level o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d04707f322a14b8f13fa7d9cca11ecd
https://doi.org/10.1016/s0021-9258(19)77876-4

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Prostatic spermine-binding protein. Cloning and nucleotide sequence of cDNA, amino acid sequence, and androgenic control of mRNA level

Autor: C S, Chang, A G, Saltzman, R A, Hiipakka, I Y, Huang, S S, Liao

Publikováno v: The Journal of biological chemistry. 262(6)

cDNA for mRNA of an androgen-dependent spermine-binding protein (SBP) of rat ventral prostate was cloned by inserting cDNA into a dG-tailed expression vector, pUC8, and screening the expression library with anti-SBP antibodies. Hybrid-selected transl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::837524733083f2858ae968d7a2ca44f0
https://pubmed.ncbi.nlm.nih.gov/3818623

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Immunochemical characterization of the androgen-dependent spermine-binding protein of the rat ventral prostate

Autor: K Schilling, S Liao, A. K. Oberhauser, R A Hiipakka, A Saltzman, C Chen

Publikováno v: The Biochemical journal. 218(2)

A solid-phase radioimmunoassay was developed to measure the level of the androgen-dependent spermine-binding protein (SBP) in the cytosol fraction of the rat ventral prostate during endocrine manipulation. The concentration of SBP and immunologically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df4f9cf19ac798267c9230001cf70af
https://pubmed.ncbi.nlm.nih.gov/6712632

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