Zobrazeno 1 - 10
of 162
pro vyhledávání: '"R. A. Herr"'
Autor:
Emily E. Freeman, Randy Jackson, Jessica Luo, Rajen Somwaru, Alex A. Sons, Andrew Bean, Ronald N. Buckle, R. Jason Herr
Publikováno v:
The Journal of Organic Chemistry. 88:2589-2598
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a5cd34d359234f9f3a8a07b7dccfb2
https://doi.org/10.1021/acs.joc.2c02670
https://doi.org/10.1021/acs.joc.2c02670
Autor:
Graham Johnson, J. H. Lin, Jinhai Yang, Xinchao Chen, Steven L. Wagner, Nicholas J. Mayhew, R. Jason Herr, William C. Mobley, Kevin D. Rynearson, William D. Paquette, Keith D. Barnes, Rudolph E. Tanzi, Samuel A. Sakwa, Phuong Nguyen, Ronald N. Buckle
Publikováno v:
Bioorganic & medicinal chemistry, vol 28, iss 22
Bioorg Med Chem
Bioorg Med Chem
The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2a9db01bac416e5d7c90cd4e945c41
https://escholarship.org/uc/item/4ps6s92t
https://escholarship.org/uc/item/4ps6s92t
Autor:
Xiaoda Niu, W. Michael Seganish, R. Jason Herr, James P. Harding, Deen Tulshian, Larry Yet, Brian J. Lavey, Thierry O. Fischmann, Koraboina Chandra Prakash, Christopher Sondey, William J. Greenlee, Jinhai Yang, Venukrishnan Komanduri, William T. McElroy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1836-1841
Interleukin receptor-associated kinase 4 (IRAK4) is a critical element of the Toll-like/interleukin-1 receptor inflammation signaling pathway. A screening campaign identified a novel diaminopyrimidine hit that exhibits weak IRAK4 inhibitory activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8341cb6919ca89d984827a91b91440ad
https://doi.org/10.1016/j.bmcl.2015.03.043
https://doi.org/10.1016/j.bmcl.2015.03.043
Autor:
Vincent E. Groppi, Kelly N. Owens, R. Jason Herr, Xinchao Chen, Edwin W. Rubel, Julian A. Simon, Graham Johnson, Qin Jiang, David W. Raible, Sarwat Chowdhury
Publikováno v:
Journal of medicinal chemistry. 61(1)
Hearing loss is a major public health concern with no pharmaceutical intervention for hearing protection or restoration. Using zebrafish neuromast hair cells—a robust model for mammalian auditory and vestibular hair cells— we identified a urea-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7a39b6646f80bd8e165518d45bfcbb
https://pubmed.ncbi.nlm.nih.gov/28992413
https://pubmed.ncbi.nlm.nih.gov/28992413
Autor:
Zheng Tan, Steve Sorota, Deen Tulshian, R. Jason Herr, William G. Earley, Charles R. Heap, Stephanie Brumfield, Terry Bridal, Jennifer Hanisak, Xiaoping Zhou, Julius Matasi, Ana Bercovici, Ginny D. Ho, Diane Rindgen, Brandy Courneya, Shu-Wei Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4110-4113
A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized and displayed potent Nav1.7 inhibitory activity and moderate selectivity over Nav1.5. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01754d087a669b8aba1f63615bf091ab
https://doi.org/10.1016/j.bmcl.2014.07.060
https://doi.org/10.1016/j.bmcl.2014.07.060
Publikováno v:
Tetrahedron Letters. 54:2018-2021
The intramolecular Friedel–Crafts cyclization was found to be effective for the synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems using simple allylic bromides tethered to activated aromatic nuclei. Amongst the various Lewis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d30b52365d31b2614ce6b711850139
https://doi.org/10.1016/j.tetlet.2013.02.012
https://doi.org/10.1016/j.tetlet.2013.02.012
Autor:
Steven L. Wagner, Phuong Nguyen, R. Jason Herr, Nicholas J. Mayhew, Ronald N. Buckle, Rudolph E. Tanzi, Keith D. Barnes, William D. Paquette, Samuel A. Sakwa, Graham Johnson, Kevin D. Rynearson
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(16)
The design and construction of a series of novel aminothiazole-derived γ-secretase modulators is described. The incorporation of heterocyclic replacements of the terminal phenyl D-ring of lead compound 1 was conducted in order to align potency with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e4f11394504d5c922610329f498c27
https://pubmed.ncbi.nlm.nih.gov/27426299
https://pubmed.ncbi.nlm.nih.gov/27426299
Autor:
Maya Gurnani, Nicholas Bauman, Cara A. Mendrick, R. Jason Herr, Paul M. McNicholas, Nathaniel Brown, Barry Antonacci, Anthony Cacciapuoti, Samuel Wainhaus, Andrew S. Chau, Michelle F. Waldman, Todd A. Black, Paul Mann, Christine Norris, Rongze Kuang, Ilias Triantafyllou, Pauline C. Ting, Yiming Xu, Robert G. Aslanian, Scott S. Walker, Reena Patel
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:5099-5106
The echinocandins are a class of semisynthetic natural products that target β-1,3-glucan synthase (GS). Their proven clinical efficacy combined with minimal safety issues has made the echinocandins an important asset in the management of fungal infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1f9234d0d4fb0c4579feb6e0de3fae
https://doi.org/10.1128/aac.00432-11
https://doi.org/10.1128/aac.00432-11
Autor:
Samuel Wainhaus, Sang Q. Lam, Rongze Kuang, Paul M. McNicholas, Andrew J. Zych, Joe F. Lee, Gang Zhou, Todd A. Black, R. Jason Herr, Robert G. Aslanian, John H. Schwerdt, David Won-Shik Kim, Scott S. Walker, Jinhai Yang, Pauline C. Ting, He-Ping Wu, Yiming Xu, Jianhua Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2890-2893
A novel series of pyridazinone analogs has been developed as potent β-1,3-glucan synthase inhibitors through structure-activity relationship study of the lead 5-[4-(benzylsulfonyl)piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one (1). The ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4798de943c5116b4affe9d399a7f51eb
https://doi.org/10.1016/j.bmcl.2011.03.083
https://doi.org/10.1016/j.bmcl.2011.03.083
Publikováno v:
The Journal of Organic Chemistry. 76:1605-1613
An enantiospecific and stereoselective total synthesis of the natural product (+)-crispine A has been demonstrated employing a Pictet-Spengler bis-cyclization reaction between commercially available (R)-(-)-methyl 2-amino-3-(3,4-dimethoxyphenyl)propa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed4bff5cb6871694b610b61d5fb6b07
https://doi.org/10.1021/jo102112k
https://doi.org/10.1021/jo102112k