Zobrazeno 1 - 10
of 1 516
pro vyhledávání: '"R. A. Harvey"'
Autor:
Christina M. Knippler, Jamie L. Arnst, Isaac E. Robinson, Veronika Matsuk, Tala O. Khatib, R. Donald Harvey, Mala Shanmugam, Janna K. Mouw, Haian Fu, Thota Ganesh, Adam I. Marcus
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109591- (2024)
Summary: Targeting cancer metabolism to limit cellular energy and metabolite production is an attractive therapeutic approach. Here, we developed analogs of the bisbiguanide, alexidine, to target lung cancer cell metabolism and assess a structure-act
Externí odkaz:
https://doaj.org/article/23b5922f597f4f7084cf0f89ddff9f8a
Autor:
Dejan Juric, Minal Barve, Ulka Vaishampayan, Desamparados Roda, Aitana Calvo, Noelia Martinez Jañez, Jose Trigo, Alastair Greystoke, R. Donald Harvey, Anthony J. Olszanski, Mateusz Opyrchal, Alexander Spira, Fiona Thistlethwaite, Begoña Jiménez, Jessica Huck Sappal, Karuppiah Kannan, Jason Riley, Cheryl Li, Cong Li, Richard C. Gregory, Harry Miao, Shining Wang
Publikováno v:
Cancer Medicine, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Mivavotinib (TAK‐659/CB‐659), a dual SYK/FLT3 inhibitor, reduced immunosuppressive immune cell populations and suppressed tumor growth in combination with anti‐PD‐1 therapy in cancer models. This dose‐escalation/expansion study inv
Externí odkaz:
https://doaj.org/article/543c6b5130f7472f8fd3b9ea9ea6f7e2
Autor:
Elizabeth Gibson, Sara Lonardi, Christopher Jackson, Armando Santoro, Jose Manuel Trigo Perez, Iwona Lugowska, R Donald Harvey, Anne O’Donnell, Richard North, Loes Maria Latten-Jansen, Marcelo Garrido Salvo, Matías Chacón, Linghui Li, Devanand Joseph, Bryan Bennett, Balmeet Gurm, Wee-Teck Ng, Aitana Calvo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/2f70d683c2e141698475c6eae60259f3
Autor:
Anna M. Avinger, Hannah Claire Sibold, Gavin Campbell, Eli Abernethy, John Bourgeois, Tekiah McClary, Shannon Blee, Margie Dixon, R. Donald Harvey, Rebecca D. Pentz
Publikováno v:
BMC Medical Ethics, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Background Although patient advocates have developed templates for standard consent forms, evaluating patient preferences for first in human (FIH) and window of opportunity (Window) trial consent forms is critical due to their unique risks.
Externí odkaz:
https://doaj.org/article/e9e7fa6552c14fb687d7b39237c750ff
Autor:
Georgiana F. Stan, Timothy W. Church, Ellie Randall, Jenna R. M. Harvey, Jon T. Brown, Kevin A. Wilkinson, Jonathan G. Hanley, Neil V. Marrion
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Accumulation of tau is observed in dementia, with human tau displaying 6 isoforms grouped by whether they display either 3 or 4 C-terminal repeat domains (3R or 4R) and exhibit no (0N), one (1N) or two (2N) N terminal repeats. Overexpression
Externí odkaz:
https://doaj.org/article/479dc19da1834338ad8d3270d0699c51
Autor:
Julia S. Lee, Charlotte B. Wagner, Stacy Prelewicz, Heena P. Kurish, Robert Walchack, Danielle A. Cenin, Seema Patel, Mimi Lo, Danielle Schlafer, Belinda K.T. Li, R. Donald Harvey III, Bestis Wasef, Jian Ying, Tibor Kovacsovics
Publikováno v:
Haematologica, Vol 108, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/e7401b710f8c401087de767fe08de484
Autor:
Mohammed Abbas Virji, Ethan D. Fechter-Leggett, Caroline P. Groth, Xiaoming Liang, Brie H. Blackley, Marcia L. Stanton, Ryan F. LeBouf, R. Reid Harvey, Rachel L. Bailey, Kristin J. Cummings, Jean M. Cox-Ganser
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
Coffee production workers are exposed to complex mixtures of gases, dust, and vapors, including the known respiratory toxins, diacetyl, and 2,3-pentanedione, which occur naturally during coffee roasting and are also present in flavorings used to flav
Externí odkaz:
https://doaj.org/article/6a46678034ab4ede80aa4eca6f24868a
Autor:
Karthick Vishwanathan, Mireille Cantarini, Karen So, Eric Masson, Jennifer Fetterolf, Suresh S. Ramalingam, R. Donald Harvey
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 41-46 (2020)
A phase I, open‐label study (NCT02197234) assessed the effects of osimertinib on simvastatin exposure in patients with advanced epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancer and disease progression post‐EGFR tyros
Externí odkaz:
https://doaj.org/article/ea83b7b40c5c49ea8689ac0cb8a348d1
Autor:
Michael S. Gordon, Geoffrey I. Shapiro, John Sarantopoulos, Dejan Juric, Brian Lu, Angeliki Zarotiadou, Jamie N. Connarn, Yvan Le Bruchec, Calin Dan Dumitru, R. Donald Harvey
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
BackgroundCitarinostat (CC-96241; previously ACY-241), an oral inhibitor of histone deacetylases (HDACs) with selectivity for HDAC6, has demonstrated synergistic anticancer activity with paclitaxel in multiple solid tumor models. Combination therapy
Externí odkaz:
https://doaj.org/article/0ab9e0c5140445e598f9434b136856c5
Autor:
Adil Daud, Ezra Cohen, Matthew Reilley, Siwen Hu-Lieskovan, Shubham Pant, Raphael Clynes, Roger Cohen, Anthony Shields, Mark Stein, Alain Mita, Bartosz Chmielowski, Yana Najjar, Elaine Shum, Joaquina Baranda, R Donald Harvey, Catherine Fleener, Ying Ding, Sowmya Chollate, Jolene Shorr, Barbara Hickingbottom, Lei Bao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/6a7db806111f4ca8b46be50a0a23239a