Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R. A. Halpin"'
Autor:
F. Matias, Ana Beatriz Gorini da Veiga, Luiz Gustavo dos Anjos Borges, Fernando Hayashi Sant'Anna, R. A. Halpin, Tatiana Schäffer Gregianini, Pedro Alves d'Azevedo, P. R. V. Fallavena, D. Wentworth
Publikováno v:
Archives of Virology. 159:621-630
During the 2009 influenza A pH1N1 pandemics in Brazil, the state that was most affected was Rio Grande do Sul (RS), with over 3,000 confirmed cases, including 298 deaths. While no cases were confirmed in 2010, 103 infections with 14 deaths by pH1N1 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46485da1201ab83d0e496d8a71088e2
https://doi.org/10.1007/s00705-013-1855-8
https://doi.org/10.1007/s00705-013-1855-8
Autor:
T A, Baillie, R A, Halpin, B K, Matuszewski, L A, Geer, C M, Chavez-Eng, D, Dean, M, Braun, G, Doss, A, Jones, T, Marks, D, Melillo, K P, Vyas
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(12)
Rofecoxib is a potent and highly selective cyclooxygenase-2 inhibitor used for the treatment of osteoarthritis and pain. Following administration of [4-(14)C]rofecoxib to intact rats, the plasma C(max) (at approximately 1 h) was followed by a seconda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef37db0a8740c37d4c22a634cea01417
https://pubmed.ncbi.nlm.nih.gov/11717181
https://pubmed.ncbi.nlm.nih.gov/11717181
Autor:
K, Kassahun, I S, McIntosh, M, Shou, D J, Walsh, C, Rodeheffer, D E, Slaughter, L A, Geer, R A, Halpin, N, Agrawal, A D, Rodrigues
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(6)
Etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, was shown to be metabolized via 6'-methylhydroxylation (M2 formation) when incubated with NADPH-fortified human liver microsomes. In agreement with in vivo data, 1'-N'-oxidation was a rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4251ee803f7a00f16a2e04101d897e03
https://pubmed.ncbi.nlm.nih.gov/11353749
https://pubmed.ncbi.nlm.nih.gov/11353749
Autor:
R A, Halpin, L A, Geer, K E, Zhang, T M, Marks, D C, Dean, A N, Jones, D, Melillo, G, Doss, K P, Vyas
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(10)
Absorption, distribution, metabolism, and excretion studies were conducted in rats and dogs with rofecoxib (VIOXX, MK-0966), a potent and highly selective inhibitor of cyclooxygenase-2 (COX-2). In rats, the nonexponential decay during the terminal ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba6fdfcf646e18936f5691a887b45235
https://pubmed.ncbi.nlm.nih.gov/10997947
https://pubmed.ncbi.nlm.nih.gov/10997947
Autor:
K P, Vyas, R A, Halpin, L A, Geer, J D, Ellis, L, Liu, H, Cheng, C, Chavez-Eng, B K, Matuszewski, S L, Varga, A R, Guiblin, J D, Rogers
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(1)
The absorption and disposition of rizatriptan (MK-0462, Maxalt(TM)), a selective 5-HT(1B/1D) receptor agonist used in the treatment of migraine headaches, was investigated in humans. In a two-period, single i.v. (3 mg, 30-min infusion), and single or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5935e4acf329ea62f4bd3e77e7176bce
https://pubmed.ncbi.nlm.nih.gov/10611145
https://pubmed.ncbi.nlm.nih.gov/10611145
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(6)
Lovastatin is a prodrug lactone whose open-chain 3,5-dihydroxy acid is a potent, competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol biosynthesis. The compound undergoes extensive and comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93d526d88efa6c3718079205001f4b4e
https://pubmed.ncbi.nlm.nih.gov/7905377
https://pubmed.ncbi.nlm.nih.gov/7905377
Autor:
K P, Vyas, P H, Kari, S M, Pitzenberger, R A, Halpin, H G, Ramjit, B, Arison, J S, Murphy, W F, Hoffman, M S, Schwartz, E H, Ulm
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(2)
Structures of in vitro microsomal and in vivo metabolites of lovastatin, a new cholesterol-lowering drug, were elucidated with the combined application of HPLC, UV, fast atom bombardment-MS, and NMR spectroscopy. Liver microsomes from rats and mice c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4fc9ac146f0c7a7b7f515cb608ae0c7e
https://pubmed.ncbi.nlm.nih.gov/1971574
https://pubmed.ncbi.nlm.nih.gov/1971574
Publikováno v:
Archives of Biochemistry and Biophysics. 144:529-540
The mode of involvement of phospholipids in the hydrolysis of ATP and the transport of Ca 2+ by sarcoplasmic reticulum membranes was studied using various phospholipases for the controlled degradation of microsomal membrane phospholipids. The hydroly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::986a58390c1fe3985408fa7de5300f34
https://doi.org/10.1016/0003-9861(71)90358-4
https://doi.org/10.1016/0003-9861(71)90358-4
Publikováno v:
Journal of Biological Chemistry. 243:61-70
Treatment of skeletal muscle microsomes with phospholipase C inhibits the adenosine triphosphatase activity and calcium transport, parallel with the selective hydrolysis of membrane lecithin. The ATPase activity of phospholipase C-treated microsomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8602f0159db3b1f2f02625758dc9a7af
https://doi.org/10.1016/s0021-9258(18)99325-7
https://doi.org/10.1016/s0021-9258(18)99325-7
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 37:455-468
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37be13f4fbbd9bd4687cf1bd115016c5
https://doi.org/10.1101/sqb.1973.037.01.057
https://doi.org/10.1101/sqb.1973.037.01.057