Zobrazeno 1 - 10
of 128
pro vyhledávání: '"R. A. Floto"'
Autor:
Marta Vilà-González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Andres Floto, Emma L. Rawlins, Pietro Cicuta, Ludovic Vallier
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Pulmonary ionocytes have been identified in the airway epithelium as a small population of ion transporting cells expressing high levels of CFTR (cystic fibrosis transmembrane conductance regulator), the gene mutated in cystic fib
Externí odkaz:
https://doaj.org/article/6ef9e41560be48c89f72cdcceb53767c
Autor:
Christopher Ruis, Aaron Weimann, Gerry Tonkin-Hill, Arun Prasad Pandurangan, Marta Matuszewska, Gemma G. R. Murray, Roger C. Lévesque, Tom L. Blundell, R. Andres Floto, Julian Parkhill
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells. We reasoned that similar processes must occur in bacterial lineages, p
Externí odkaz:
https://doaj.org/article/cc2a1f59c84346ceb130c517a1c473fa
Autor:
Juan M. Belardinelli, Divya Arora, Charlotte Avanzi, William H. Wheat, Josephine M. Bryant, John S. Spencer, Tom L. Blundell, Julian Parkhill, R. Andres Floto, Mary Jackson
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Functional genomics analysis of Mycobacterium abscessus clinical isolates from chronically infected patients to identify genes under strong evolutionary pressure during lung adaptation identified phoR as one of the most frequently mutated. p
Externí odkaz:
https://doaj.org/article/2bf422acc9ed4da6817771c9620be1e0
Publikováno v:
BMC Microbiology, Vol 22, Iss 1, Pp 1-23 (2022)
Abstract Background Campylobacter spp. are the leading cause of bacterial food-borne illness in humans worldwide, with Campylobacter jejuni responsible for 80% of these infections. There is an urgent need to understand fundamental C. jejuni biology f
Externí odkaz:
https://doaj.org/article/80dd19882e1d4b779a22834a30538aaf
Autor:
Jing Han, Marco Montagna, Andreas Grammenos, Tong Xia, Erika Bondareva, Chloë Siegele-Brown, Jagmohan Chauhan, Ting Dang, Dimitris Spathis, R Andres Floto, Pietro Cicuta, Cecilia Mascolo
Publikováno v:
Journal of Medical Internet Research, Vol 25, p e44804 (2023)
BackgroundTo date, performance comparisons between men and machines have been carried out in many health domains. Yet machine learning (ML) models and human performance comparisons in audio-based respiratory diagnosis remain largely unexplored. Obje
Externí odkaz:
https://doaj.org/article/c15dee87ce7142daa4c4b6f75c46a925
Autor:
Jonathan X. Meng, Yu Zhang, Dominik Saman, Arshad M. Haider, Suman De, Jason C. Sang, Karen Brown, Kun Jiang, Jane Humphrey, Linda Julian, Eric Hidari, Steven F. Lee, Gabriel Balmus, R. Andres Floto, Clare E. Bryant, Justin L. P. Benesch, Yu Ye, David Klenerman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In this work, the authors report that hyperphosphorylated recombinant tau spontaneously assembles into small, amorphous aggregates, which disrupt membranes and induce Toll-like receptor 4-dependent responses in human macrophages.
Externí odkaz:
https://doaj.org/article/bc2803e2004a427bb2eed72cdc9d158e
Autor:
Ting Dang, Jing Han, Tong Xia, Dimitris Spathis, Erika Bondareva, Chloë Siegele-Brown, Jagmohan Chauhan, Andreas Grammenos, Apinan Hasthanasombat, R Andres Floto, Pietro Cicuta, Cecilia Mascolo
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 6, p e37004 (2022)
BackgroundRecent work has shown the potential of using audio data (eg, cough, breathing, and voice) in the screening for COVID-19. However, these approaches only focus on one-off detection and detect the infection, given the current audio sample, but
Externí odkaz:
https://doaj.org/article/df5c0bb76c3846388d3ae914697b6fdf
Autor:
Sherine E. Thomas, William J. McCarthy, Jamal El Bakali, Karen P. Brown, So Yeon Kim, Michal Blaszczyk, Vítor Mendes, Chris Abell, R. Andres Floto, Anthony G. Coyne, Tom L. Blundell
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Anti-microbial resistance is a rising global healthcare concern that needs urgent attention as growing number of infections become difficult to treat with the currently available antibiotics. This is particularly true for mycobacterial infections lik
Externí odkaz:
https://doaj.org/article/2ec45fe855c2444086e1ec68c5424f59
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Cystic fibrosis (CF) is progressive genetic disease that predisposes lungs and other organs to multiple long-lasting microbial infections. Pseudomonas aeruginosa is the most prevalent and deadly pathogen among these microbes. Lung function of CF pati
Externí odkaz:
https://doaj.org/article/37eef4c99643428e8433970b85111f39
Autor:
Gerry Tonkin-Hill, Neil MacAlasdair, Christopher Ruis, Aaron Weimann, Gal Horesh, John A. Lees, Rebecca A. Gladstone, Stephanie Lo, Christopher Beaudoin, R. Andres Floto, Simon D.W. Frost, Jukka Corander, Stephen D. Bentley, Julian Parkhill
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-21 (2020)
Abstract Population-level comparisons of prokaryotic genomes must take into account the substantial differences in gene content resulting from horizontal gene transfer, gene duplication and gene loss. However, the automated annotation of prokaryotic
Externí odkaz:
https://doaj.org/article/2f993c35887e4f39985ba6d4d8cee246