Zobrazeno 1 - 10
of 79
pro vyhledávání: '"R. A. De Zeeuw"'
A Fluorescent Receptor Assay for Benzodiazepines Using Coumarin-Labeled Desethylflumazenil as Ligand
Publikováno v:
Analytical Chemistry. 73:3168-3173
This article describes a novel nonisotopic receptor assay for benzodiazepines with fluorescence detection, As labeled ljgand (coumarin-labeled desethylflumazenil, CLDEF), a metabolite of the benzodiazepine antagonist flumazenil (desetheylflumazenil,
Autor:
K, Ensing, R A, de Zeeuw
Publikováno v:
Pharmaceutical research. 3(6)
A number of corresponding tertiary and quaternary anticholinergic analogues were examined for their ability to inhibit specific (3)H-dexetimide binding to calf brain muscarinic receptors. In all cases the tertiary antagonists (except pirenzepine) sho
Publikováno v:
Preparative Biochemistry. 25:197-221
Autor:
K. de Jonge, R. A. de Zeeuw, A. P. Bruins, A. B. L. Lanting, K Ensing, B. F. H. Drenth, Dirk K. F. Meijer
Publikováno v:
Biological Mass Spectrometry. 22:226-234
To gather more information on stereochemical factors in the hepatic disposition of organic cations, mass spectrometry coupled to liquid chromatography was used to determine the identity of the metabolites excreted in bile after isolated rat liver per
Publikováno v:
Xenobiotica. 20:515-524
1. The disposition and metabolic profiling of 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin(I), a dopamine agonist, were studied in anaesthetized rats after i.v. administration and in non-anaesthetized rats after i.v. and oral dosing. No major
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 794(1)
Solid-phase extraction (SPE) was directly coupled to mass spectrometry (MS) to assess the feasibility of the system for the rapid determination of prednisolone in serum. A C(18) stationary phase allowed washing of the cartridge with 25% methanol. Elu
Publikováno v:
Rapid communications in mass spectrometry : RCM. 17(3)
Ion suppression effects were observed during the determination of clenbuterol in urine with solid-phase extraction/multiple-stage ion-trap mass spectrometry (SPE/MS(3)), despite the use of atmospheric pressure chemical ionisation. During SPE, a polym
Publikováno v:
Forensic Science International, 121(1-2), 89-96
Capillary electrophoresis (CE) is a modern separation technique that has some distinct advantages for toxicological analysis, such as a high efficiency, fast analysis, flexibility, and complementary separation mechanisms to chromatographic methods. C
Publikováno v:
Electrophoresis. 21(15)
A review is presented on the use of charged cyclodextrins (CDs) as chiral selectors in capillary electrophoresis (CE) for the separation of analytes in pharmaceutical analysis. An overview is given of theoretical models that have been developed for a
Publikováno v:
Electrophoresis. 21(8)
The intra- and interinstrument reproducibilities of four capillary electrophoresis instruments were studied for identification purposes in systematic toxicological analysis (STA). A test set of 20 acidic test compounds and 5 reference compounds were