Zobrazeno 1 - 10
of 271
pro vyhledávání: '"R. Scott Obach"'
Autor:
Britton Boras, Rhys M. Jones, Brandon J. Anson, Dan Arenson, Lisa Aschenbrenner, Malina A. Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E. Haupt, Robert Hoffman, Eugene P. Kadar, Rob Kania, Emi Kimoto, Melanie G. Kirkpatrick, Lorraine Lanyon, Emma K. Lendy, Jonathan R. Lillis, James Logue, Suman A. Luthra, Chunlong Ma, Stephen W. Mason, Marisa E. McGrath, Stephen Noell, R. Scott Obach, Matthew N. O’ Brien, Rebecca O’Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R. Reese, Thomas F. Rogers, Romel Rosales, Michelle I. Rossulek, Jean G. Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W. Updyke, Stuart Weston, Yuao Zhu, Kris M. White, Adolfo García-Sastre, Jun Wang, Arnab K. Chatterjee, Andrew D. Mesecar, Matthew B. Frieman, Annaliesa S. Anderson, Charlotte Allerton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical developm
Externí odkaz:
https://doaj.org/article/7c0ac56767d64fb5af7714d7f3a62322
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 8, Pp 428-434 (2020)
The human radiolabeled absorption, distribution, metabolism, and excretion (ADME) study offers a quantitative and comprehensive overall picture of the disposition of a drug, including excretion pattern and metabolite profiles in circulation and excre
Externí odkaz:
https://doaj.org/article/0233e079d5dd48d799a3368daefcf5a8
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 3, Pp 520-528 (2020)
In the development of new drugs, the prediction of metabolite‐to‐parent plasma exposure ratio in humans prior to administration in a clinical study has emerged as an important need. In this work, we derived a mechanistic static model based on fir
Externí odkaz:
https://doaj.org/article/a5962f72080f49b789a37b1f1f7d4bc9
Publikováno v:
Drug Metabolism and Disposition. 51:647-656
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c81e540d25cba62b9d4044ff411e6e9
https://doi.org/10.1124/dmd.122.001006
https://doi.org/10.1124/dmd.122.001006
Autor:
Angela C. Doran, Alyssa L. Dantonio, Gabrielle M. Gualtieri, Amanda Balesano, Connor Landers, Woodrow Burchett, Theunis C. Goosen, R. Scott Obach
Publikováno v:
Drug Metabolism and Disposition. 50:1272-1286
Cytochrome P450 reaction phenotyping to determine the fraction of metabolism values (f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d75f4c59170879ccb0e19a61073e75
https://doi.org/10.1124/dmd.122.000883
https://doi.org/10.1124/dmd.122.000883
Autor:
Heather Eng, Alyssa L. Dantonio, Eugene P. Kadar, R. Scott Obach, Li Di, Jian Lin, Nandini C. Patel, Britton Boras, Gregory S. Walker, Jonathan J. Novak, Emi Kimoto, Ravi Shankar P. Singh, Amit S. Kalgutkar
Publikováno v:
Drug Metabolism and Disposition. 50:576-590
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease inhibitor PF-07321332 (nirmatrelvir), in combination with ritonavir (Paxlovid), was recently granted emergency use authorization by multiple regulatory agencies for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7665fc87be6818aa4890655b732a8a9d
https://doi.org/10.1124/dmd.121.000801
https://doi.org/10.1124/dmd.121.000801
Autor:
Nandini Chaturbhai Patel, Dafydd R. Owen, Rhonda D. Cardin, Karen J. Coffman, Jean G. Sathish, Devendra K. Rai, Heather Eng, Charlotte Moira Norfor Allerton, Jack C. Lee, Britton Boras, Melissa Avery, Qingyi Yang, Eugene P. Kadar, Anthony Carlo, Annaliesa S. Anderson, Matthew R. Reese, Li Di, Jisun Lee, Lisa Aschenbrenner, Stephen Noell, Lawrence W. Updyke, Martin Pettersson, Scott A. Gibson, Matthew F. Sammons, Al E. Stewart, Yuao Zhu, Alyssa Dantonio, Stephen W. Mason, Brett L. Hurst, Ketan S. Gajiwala, Claire M. Steppan, Liuqing Wei, Patrick Robert Verhoest, Samantha Elizabeth Greasley, Simon Berritt, R. Scott Obach, RoseAnn Ferre, Ravi Shankar P. Singh, Amit S. Kalgutkar, Jonathan J. Novak, Kevin Ogilvie, Wei Liu, Jamison B. Tuttle
Publikováno v:
Science. 374:1586-1593
Path to another drug against COVID-19 The rapid development of vaccines has been crucial in battling the ongoing COVID-19 pandemic. However, access challenges remain, breakthrough infections occur, and emerging variants present increased risk. Develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afda196cafc9555c41b81b6f1866c49a
https://doi.org/10.1126/science.abl4784
https://doi.org/10.1126/science.abl4784
Publikováno v:
Drug Metabolism and Disposition. 50:249-257
The use of intersystem extrapolation factors (ISEF) is required for the quantitative scaling of drug metabolism data generated in individually expressed cytochrome P450 (CYP) enzymes when estimating fractional contribution (f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941225e19aefe188cfbb733507d966d3
https://doi.org/10.1124/dmd.121.000758
https://doi.org/10.1124/dmd.121.000758
Autor:
Heather Eng, Theunis C. Goosen, Jian Lin, Matthew A. Cerny, R. Scott Obach, Elaine E. Tseng, David A. Tess
Publikováno v:
Drug Metabolism and Disposition. 49:947-960
Cytochrome P450 3A (CYP3A) is a frequent target for time-dependent inhibition (TDI) that can give rise to drug-drug interactions (DDI). Yet many drugs that exhibit in vitro TDI for CYP3A do not result in DDI. There were 23 drugs with published clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803b29b300056a42da5a7eb10db6e944
https://doi.org/10.1124/dmd.121.000497
https://doi.org/10.1124/dmd.121.000497
Autor:
Angela C. Doran, Woodrow Burchett, Connor Landers, Gabrielle M. Gualtieri, Amanda Balesano, Heather Eng, Alyssa L Dantonio, Theunis C. Goosen, R. Scott Obach
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals.
The utility of chemical inhibitors in cytochrome P450 (CYP) reaction phenotyping is highly dependent on their selectivity and potency for their target CYP isoforms. In the present study, seventeen inhibitors of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fdb54fca7319cb247bf9771b45d19f
https://pubmed.ncbi.nlm.nih.gov/35777846
https://pubmed.ncbi.nlm.nih.gov/35777846