Zobrazeno 1 - 10
of 400
pro vyhledávání: '"R. Schwabe"'
Autor:
M. R. Schwabe, A. W. Fleischer, R. K. Kuehn, S. Chaudhury, J. M. York, D. S. Sem, W. A. Donaldson, M. J. LaDu, K. M. Frick
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionAlzheimer’s disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and a
Externí odkaz:
https://doaj.org/article/2fa33de520194c4b98365d1a00ebbd49
Autor:
Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The core FADD:Caspase-8 complex and its regulatory partners, such as the cell death inhibitor c-FLIP, coordinate cell fate. Here authors present the structure of full-length procaspase-8 in a complex with FADD and reveal how recruitment of c-FLIPS in
Externí odkaz:
https://doaj.org/article/cbf43a167d5c47dbbf9efdc46a691fd7
Autor:
Neil Bate, Christos G Savva, Peter C E Moody, Edward A Brown, Sian E Evans, Jonathan K Ball, John W R Schwabe, Julian E Sale, Nicholas P J Brindle
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010733 (2022)
Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to increased transmissibility or immune evasion would be extremely valuable in develop
Externí odkaz:
https://doaj.org/article/1c450b5c20754a42910056edeab3abf1
Autor:
Robert E. Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L. Morris, T. J. Ragan, Christos G. Savva, Aditya Chandru, Christopher J. Millard, Olga V. Makarova, Corinne J. Smith, Alan M. Roseman, Andrew M. Fry, Shaun M. Cowley, John W. R. Schwabe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM struct
Externí odkaz:
https://doaj.org/article/6a71d260306a424c936ce21edc133482
A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Autor:
Tianyi Zhang, Guifeng Wei, Christopher J. Millard, Roman Fischer, Rebecca Konietzny, Benedikt M. Kessler, John W. R. Schwabe, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Transcription regulation requires recruitment of different epigenetic regulators to the chromatin. Here the authors provide evidence that an H3K36me3 reader PWWP2A forms a variant NuRD complex and plays a role in regulating transcription and histone
Externí odkaz:
https://doaj.org/article/5054f4fdda3244658206c728b04b321a
Autor:
Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets
Externí odkaz:
https://doaj.org/article/879832a39de54eeeb00cc6a12113408e
Akademický článek
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Autor:
Peter J. Watson, Christopher J. Millard, Andrew M. Riley, Naomi S. Robertson, Lyndsey C. Wright, Himali Y. Godage, Shaun M. Cowley, Andrew G. Jamieson, Barry V. L. Potter, John W. R. Schwabe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically dr
Externí odkaz:
https://doaj.org/article/8c4612cc08aa4272b0bb9490a5928eeb
Autor:
Zhipeng A. Wang, Samuel D. Whedon, Mingxuan Wu, Siyu Wang, Edward A. Brown, Ananya Anmangandla, Liam Regan, Kwangwoon Lee, Jianfeng Du, Jun Young Hong, Louise Fairall, Taylor Kay, Hening Lin, Yingming Zhao, John W. R. Schwabe, Philip A. Cole
Publikováno v:
Journal of the American Chemical Society. 144:3360-3364
We describe a new method to produce histone H2B by semisynthesis with an engineered sortase transpeptidase. N-Terminal tail site-specifically modified acetylated, lactylated, and β-hydroxybutyrylated histone H2Bs were incorporated into nucleosomes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b42f643da4cea27457c1d37bbc02ee
https://doi.org/10.1021/jacs.1c13555
https://doi.org/10.1021/jacs.1c13555
Autor:
Siyu Wang, Louise Fairall, Trong Khoa Pham, Timothy J Ragan, Dipti Vashi, Mark O Collins, Cyril Dominguez, John W R Schwabe
Publikováno v:
Nucleic Acids Research.
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a06ebabb80f9a7c5a2844878c00767
https://doi.org/10.1093/nar/gkad294
https://doi.org/10.1093/nar/gkad294