Zobrazeno 1 - 10
of 515
pro vyhledávání: '"R. McMullen"'
Autor:
Nicola M. Sergienko, Adam J. Trewin, Helen Kiriazis, Antonia J. A. Raaijmakers, Daniel G. Donner, Victoria C. Garside, Kelly A. Smith, James R. Bell, Kimberley M. Mellor, Lea M. D. Delbridge, Julie R. McMullen, Kate L. Weeks
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-13 (2024)
Abstract Protein phosphatase 2A (PP2A) regulatory subunit B55α has been implicated in the transcriptional regulation of cardiac growth and fibrosis by suppressing HDAC5/MEF2 signalling in cardiomyocytes. We created and characterised two mouse models
Externí odkaz:
https://doaj.org/article/962f0a0f34444cd0b5607aa60b031817
Autor:
Teleah G. Belkin, Emma I. Masterman, Gunes S. Yildiz, Helen Kiriazis, Natalie A. Mellett, Jonathon Cross, Kyah Grigolon, Akshima Dogra, Daniel Donner, Roger Chooi, Amy Liang, Andrew R. Kompa, Junichi Sadoshima, Amanda J. Edgley, David W. Greening, Peter J. Meikle, Yow Keat Tham, Julie R. McMullen
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 11, Iss , Pp 100273- (2025)
We previously reported that plasmalogens, a class of phospholipids, were decreased in a setting of dilated cardiomyopathy (DCM). Plasmalogen levels can be modulated via a dietary supplement called alkylglycerols (AG) which has demonstrated benefits i
Externí odkaz:
https://doaj.org/article/909d78382e0e400787bfb45011da8c59
Autor:
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Anthony J Horak, Megan R McMullen, Emily Huang, Annette Bellar, Shuhui W Lorkowski, Kailash Gulshan, Robert N Helsley, Isabella James, Vai Pathak, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, David Streem, Ofer Reizes, Daniela S Allende, Jonathan D Smith, Judith Simcox, Laura E Nagy, J Mark Brown
Publikováno v:
eLife, Vol 12 (2024)
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced MBOAT7 ex
Externí odkaz:
https://doaj.org/article/3c5d86faa2f749f9b1ff225029440203
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundThe RIP1-RIP3-MLKL-mediated cell death pathway is associated with progression of non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). Previous work identified a critical role for MLKL, the key effector regulating necroptosis, but
Externí odkaz:
https://doaj.org/article/b59b614ce2774f44987134d4f15e2a72
Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes
Autor:
Aowen Zhuang, Yanie Tan, Yingying Liu, Christine Yang, Helen Kiriazis, Kyah Grigolon, Shannen Walker, Simon T. Bond, Julie R. McMullen, Anna C. Calkin, Brian G. Drew
Publikováno v:
Physiological Reports, Vol 11, Iss 23, Pp n/a-n/a (2023)
Abstract Long ncRNAs (lncRNAs) have been shown to play a biological and physiological role in various tissues including the heart. We and others have previously established that the lncRNA Oip5os1 (1700020I14Rik, OIP5‐AS1, Cyrano) is enriched in st
Externí odkaz:
https://doaj.org/article/1b95d6a3a9ba480f80f77c3578a83ad1
Autor:
Adam Kim, Martí Ortega-Ribera, Megan R. McMullen, Annette Bellar, Moyinoluwa Taiwo, Vai Pathak, David Streem, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, Vidula Vachharajani, Laura E. Nagy
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107133- (2023)
Summary: Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also overweight, yet the molecular me
Externí odkaz:
https://doaj.org/article/d98479cccd364976b87e0478ee4d52c3
Autor:
C. Alicia Traughber, Gauravi M. Deshpande, Kalash Neupane, Nilam Bhandari, Mariam R. Khan, Megan R. McMullen, Shadi Swaidani, Emmanuel Opoku, Santoshi Muppala, Jonathan D. Smith, Laura E. Nagy, Kailash Gulshan
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106076- (2023)
Summary: The activities of the NLRP3 and AIM2 inflammasomes and Gasdermin D (GsdmD) are implicated in lung cancer pathophysiology but it’s not clear if their contributions promote or retard lung cancer progression. Using a metastatic Lewis lung car
Externí odkaz:
https://doaj.org/article/01281b11f26d44f2bd22e002e5c57436
Publikováno v:
Journal of Sport and Health Science, Vol 10, Iss 6, Pp 637-647 (2021)
Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing health burden and a leading cause of death worldwide. To date, limited treatment options exist for the treatment of heart failure, but exercise has been w
Externí odkaz:
https://doaj.org/article/65d4df39025b4588a915ed4274ed9b9c
Autor:
Tatsunori Miyata, Xiaoqin Wu, Xiude Fan, Emily Huang, Carlos Sanz-Garcia, Christina K. Cajigas-Du Ross, Sanjoy Roychowdhury, Annette Bellar, Megan R. McMullen, Jaividhya Dasarathy, Daniela S. Allende, Joan Caballeria, Pau Sancho-Bru, Craig J. McClain, Mack Mitchell, Arthur J. McCullough, Svetlana Radaeva, Bruce Barton, Gyongyi Szabo, Srinivasan Dasarathy, Laura E. Nagy
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Externí odkaz:
https://doaj.org/article/62602ca604e54c7997de01962de6b453
Autor:
Shashi Shekhar Singh, Avinash Kumar, Nicole Welch, Jinendiran Sekar, Saurabh Mishra, Annette Bellar, Mahesha Gangadhariah, Amy Attaway, Hayder Al Khafaji, Xiaoqin Wu, Vai Pathak, Vandana Agrawal, Megan R. McMullen, Troy A. Hornberger, Laura E. Nagy, Gangarao Davuluri, Srinivasan Dasarathy
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss 1, Pp 91-116 (2021)
Externí odkaz:
https://doaj.org/article/149adb9bba314f0284ac3b35b53225aa