Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Autor: Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. MacDonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M. Fan, Jianmin Wang, Philip L. McCarthy, Elizabeth A. Repasky, Hemn Mohammadpour

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy

Externí odkaz: https://doaj.org/article/38460ce622de479f9a32204e95da4901

Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses

Autor: Tomás Cervantes Rincón, Tania Kapoor, Jennifer R. Keeffe, Luca Simonelli, Hans-Heinrich Hoffmann, Marianna Agudelo, Andrea Jurado, Avery Peace, Yu E. Lee, Anna Gazumyan, Francesca Guidetti, Jasmine Cantergiani, Benedetta Cena, Filippo Bianchini, Elia Tamagnini, Simone G. Moro, Pavel Svoboda, Federico Costa, Mitermayer G. Reis, Albert I. Ko, Brian A. Fallon, Santiago Avila-Rios, Gustavo Reyes-Téran, Charles M. Rice, Michel C. Nussenzweig, Pamela J. Bjorkman, Daniel Ruzek, Luca Varani, Margaret R. MacDonald, Davide F. Robbiani

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114298- (2024)

Summary: Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic il

Externí odkaz: https://doaj.org/article/f2a8209fd48e4756be5a885d97b8d72f

First Sagittarius A* Event Horizon Telescope Results. VIII. Physical Interpretation of the Polarized Ring

Autor: The Event Horizon Telescope Collaboration, Kazunori Akiyama, Antxon Alberdi, Walter Alef, Juan Carlos Algaba, Richard Anantua, Keiichi Asada, Rebecca Azulay, Uwe Bach, Anne-Kathrin Baczko, David Ball, Mislav Baloković, Bidisha Bandyopadhyay, John Barrett, Michi Bauböck, Bradford A. Benson, Dan Bintley, Lindy Blackburn, Raymond Blundell, Katherine L. Bouman, Geoffrey C. Bower, Hope Boyce, Michael Bremer, Christiaan D. Brinkerink, Roger Brissenden, Silke Britzen, Avery E. Broderick, Dominique Broguiere, Thomas Bronzwaer, Sandra Bustamante, Do-Young Byun, John E. Carlstrom, Chiara Ceccobello, Andrew Chael, Chi-kwan Chan, Dominic O. Chang, Koushik Chatterjee, Shami Chatterjee, Ming-Tang Chen, Yongjun Chen, Xiaopeng Cheng, Ilje Cho, Pierre Christian, Nicholas S. Conroy, John E. Conway, James M. Cordes, Thomas M. Crawford, Geoffrey B. Crew, Alejandro Cruz-Osorio, Yuzhu Cui, Rohan Dahale, Jordy Davelaar, Mariafelicia De Laurentis, Roger Deane, Jessica Dempsey, Gregory Desvignes, Jason Dexter, Vedant Dhruv, Indu K. Dihingia, Sheperd S. Doeleman, Sean Dougall, Sergio A. Dzib, Ralph P. Eatough, Razieh Emami, Heino Falcke, Joseph Farah, Vincent L. Fish, Edward Fomalont, H. Alyson Ford, Marianna Foschi, Raquel Fraga-Encinas, William T. Freeman, Per Friberg, Christian M. Fromm, Antonio Fuentes, Peter Galison, Charles F. Gammie, Roberto García, Olivier Gentaz, Boris Georgiev, Ciriaco Goddi, Roman Gold, Arturo I. Gómez-Ruiz, José L. Gómez, Minfeng Gu, Mark Gurwell, Kazuhiro Hada, Daryl Haggard, Kari Haworth, Michael H. Hecht, Ronald Hesper, Dirk Heumann, Luis C. Ho, Paul Ho, Mareki Honma, Chih-Wei L. Huang, Lei Huang, David H. Hughes, Shiro Ikeda, C. M. Violette Impellizzeri, Makoto Inoue, Sara Issaoun, David J. James, Buell T. Jannuzi, Michael Janssen, Britton Jeter, Wu Jiang, Alejandra Jiménez-Rosales, Michael D. Johnson, Svetlana Jorstad, Abhishek V. Joshi, Taehyun Jung, Mansour Karami, Ramesh Karuppusamy, Tomohisa Kawashima, Garrett K. Keating, Mark Kettenis, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kim, Motoki Kino, Jun Yi Koay, Prashant Kocherlakota, Yutaro Kofuji, Patrick M. Koch, Shoko Koyama, Carsten Kramer, Joana A. Kramer, Michael Kramer, Thomas P. Krichbaum, Cheng-Yu Kuo, Noemi La Bella, Tod R. Lauer, Daeyoung Lee, Sang-Sung Lee, Po Kin Leung, Aviad Levis, Zhiyuan Li, Rocco Lico, Greg Lindahl, Michael Lindqvist, Mikhail Lisakov, Jun Liu, Kuo Liu, Elisabetta Liuzzo, Wen-Ping Lo, Andrei P. Lobanov, Laurent Loinard, Colin J. Lonsdale, Amy E. Lowitz, Ru-Sen Lu, Nicholas R. MacDonald, Jirong Mao, Nicola Marchili, Sera Markoff, Daniel P. Marrone, Alan P. Marscher, Iván Martí-Vidal, Satoki Matsushita, Lynn D. Matthews, Lia Medeiros, Karl M. Menten, Daniel Michalik, Izumi Mizuno, Yosuke Mizuno, James M. Moran, Kotaro Moriyama, Monika Moscibrodzka, Wanga Mulaudzi, Cornelia Müller, Hendrik Müller, Alejandro Mus, Gibwa Musoke, Ioannis Myserlis, Andrew Nadolski, Hiroshi Nagai, Neil M. Nagar, Masanori Nakamura, Gopal Narayanan, Iniyan Natarajan, Antonios Nathanail, Santiago Navarro Fuentes, Joey Neilsen, Roberto Neri, Chunchong Ni, Aristeidis Noutsos, Michael A. Nowak, Junghwan Oh, Hiroki Okino, Héctor Olivares, Gisela N. Ortiz-León, Tomoaki Oyama, Feryal Özel, Daniel C. M. Palumbo, Georgios Filippos Paraschos, Jongho Park, Harriet Parsons, Nimesh Patel, Ue-Li Pen, Dominic W. Pesce, Vincent Piétu, Richard Plambeck, Aleksandar PopStefanija, Oliver Porth, Felix M. Pötzl, Ben Prather, Jorge A. Preciado-López, Dimitrios Psaltis, Hung-Yi Pu, Venkatessh Ramakrishnan, Ramprasad Rao, Mark G. Rawlings, Alexander W. Raymond, Luciano Rezzolla, Angelo Ricarte, Bart Ripperda, Freek Roelofs, Alan Rogers, Cristina Romero-Cañizales, Eduardo Ros, Arash Roshanineshat, Helge Rottmann, Alan L. Roy, Ignacio Ruiz, Chet Ruszczyk, Kazi L. J. Rygl, Salvador Sánchez, David Sánchez-Argüelles, Miguel Sánchez-Portal, Mahito Sasada, Kaushik Satapathy, Tuomas Savolainen, F. Peter Schloerb, Jonathan Schonfeld, Karl-Friedrich Schuster, Lijing Shao, Zhiqiang Shen, Des Small, Bong Won Sohn, Jason SooHoo, León David Sosapanta Salas, Kamal Souccar, Joshua S. Stanway, He Sun, Fumie Tazaki, Alexandra J. Tetarenko, Paul Tiede, Remo P. J. Tilanus, Michael Titus, Pablo Torne, Teresa Toscano, Efthalia Traianou, Tyler Trent, Sascha Trippe, Matthew Turk, Ilse van Bemmel, Huib Jan van Langevelde, Daniel R. van Rossum, Jesse Vos, Jan Wagner, Derek Ward-Thompson, John Wardle, Jasmin E. Washington, Jonathan Weintroub, Robert Wharton, Maciek Wielgus, Kaj Wiik, Gunther Witzel, Michael F. Wondrak, George N. Wong, Qingwen Wu, Nitika Yadlapalli, Paul Yamaguchi, Aristomenis Yfantis, Doosoo Yoon, André Young, Ken Young, Ziri Younsi, Wei Yu, Feng Yuan, Ye-Fei Yuan, J. Anton Zensus, Shuo Zhang, Guang-Yao Zhao, Shan-Shan Zhao, Mahdi Najafi-Ziyazi

Publikováno v: The Astrophysical Journal Letters, Vol 964, Iss 2, p L26 (2024)

In a companion paper, we present the first spatially resolved polarized image of Sagittarius A* on event horizon scales, captured using the Event Horizon Telescope, a global very long baseline interferometric array operating at a wavelength of 1.3 mm

Externí odkaz: https://doaj.org/article/6d509d85e20d40a983932d437e50b26a

A data directory to facilitate investigations on worldwide wildlife trafficking

Autor: Meredith L. Gore, Rowan Hilend, Jonathan O. Prell, Emily Griffin, John R. Macdonald, Burcu B. Keskin, Aaron Ferber, Bistra Dilkina

Publikováno v: Big Earth Data, Vol 7, Iss 2, Pp 338-348 (2023)

ABSTRACTWildlife trafficking is a global phenomenon posing many negative impacts on socio-environmental systems. Scientific exploration of wildlife trafficking trends and the impact of interventions is significantly encumbered by a suite of data reus

Externí odkaz: https://doaj.org/article/4ca16feaf881451982b1f401ebc153ac

Delightful Acts : New Essays on Canonical and Non-canonical Acts

Autor: Harold W. Attridge, Dennis R. MacDonald, Clare K. Rothschild

The primary impetus of this collection of essays on canonical and non-canonical Acts is to honor the scholarly achievements of Richard I. Pervo. Pervo pioneered the view that canonical Acts is comparable to ancient fiction, insofar as the various epi